A5100781062- Gastrointestinal Tumor Research and Treatment
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Action Observation and Synchronization
- Chemokine receptors and signaling
- Geological and Geophysical Studies
- Criminal Law and Policy
- Cell Adhesion Molecules Research
- Ion Channels and Receptors
- S100 Proteins and Annexins
- Nerve injury and regeneration
- Mechanisms of cancer metastasis
- Neural and Behavioral Psychology Studies
- Neurobiology and Insect Physiology Research
- Healthcare Technology and Patient Monitoring
- Colorectal Cancer Surgical Treatments
- Ion channel regulation and function
- Minimally Invasive Surgical Techniques
- Cancer, Hypoxia, and Metabolism
- Antimicrobial Peptides and Activities
- Medical and Health Sciences Research
- Medical Imaging Techniques and Applications
- Computational Physics and Python Applications
- Pancreatic and Hepatic Oncology Research
- Empathy and Medical Education
Heidelberg University
2022
MSB Medical School Berlin
2020
Charité - Universitätsmedizin Berlin
2004-2009
Freie Universität Berlin
2000
The low extracellular pH of inflamed or ischemic tissues enhances painful sensations by sensitizing and activating the vanilloid receptor 1 (TRPV1). We report here that activation TRPV1 results in a marked intracellular acidification nociceptive dorsal root ganglion neurons heterologous expression system. A characterization underlying mechanisms revealed Ca2+-dependent operating at neutral an additional as yet unrecognized direct proton conductance through poorly selective pore acidic media....
Leukocytes counteract inflammatory pain by releasing opioid peptides, which bind to receptors on peripheral sensory neurons. In the early phase of inflammation, polymorphonuclear cells (PMN) are major source opioids. Their recruitment is governed ligands at chemokine receptor CXCR2. Here, we examined whether chemokines can also induce peptide secretion from PMN and thus inhibit pain. rats with hindpaw intraplantar injection CXCL2/3, but not CXCR4 ligand CXCL12, elicited naloxone-reversible...
In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted neutrophils at the site leading to activation receptors on peripheral sensory neurons. humans, local opioids significantly downregulate postoperative as well arthritic pain. rats, inflammatory induced intraplantar injection heat inactivated Mycobacterium butyricum, component complete Freund's adjuvant. We hypothesized that mycobacterially derived...
Several collagen subtypes are involved in pancreatic ductal adenocarcinoma (PDAC) desmoplasia, which constrains therapeutic efficacy. We evaluated type VIII alpha 1 chain (COL8A1), whose function PDAC is currently unknown. identified COL8A1 expression 7 examined cell lines by microarray analysis, western blotting, and RT‒qPCR. Higher occurred 2 gemcitabine-resistant lines; pancreas tissue (n=15) from LSL-KrasG12D/+; p48-Cre mice with advanced predisposition; parenchyma stroma of a patient...
Natural orifice transluminal endoscopic surgery (NOTES) has recently evolved as a novel approach for abdominal with great potential to further improve the advantages of laparoscopy over laparotomy. The first patients undergoing NOTES cholecystectomy or appendectomy reported no only minimal pain, required narcotic analgesics, and were discharged early from hospital immediately resumed daily activities. If this is confirmed by randomized controlled clinical trials, what are implications anesthesia?
Empathic concerns influence how we perceive, understand, and interact with our social environment. Previous studies suggested a network of different brain regions as neural substrate for empathy, including, in particular, insula anterior cingulate cortex (ACC). In addition, contribution the somatosensory cortices this empathy related has been suggested. This is remarkable given that other recent have revealed role various tasks. For example, experiments using tactile priming, incidental...