A5003228885- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Cell Adhesion Molecules Research
- Dental Implant Techniques and Outcomes
- Knee injuries and reconstruction techniques
- Inflammatory mediators and NSAID effects
- Tendon Structure and Treatment
- Tissue Engineering and Regenerative Medicine
- 3D Printing in Biomedical Research
- Bone health and treatments
- Hydrogels: synthesis, properties, applications
- Dental materials and restorations
- Cannabis and Cannabinoid Research
- Collagen: Extraction and Characterization
- RNA Interference and Gene Delivery
- Protease and Inhibitor Mechanisms
- Graphene and Nanomaterials Applications
- Mesenchymal stem cell research
- Peptidase Inhibition and Analysis
- Glycogen Storage Diseases and Myoclonus
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
Michigan State University
2025
University of Sheffield
2010-2023
Letterkenny University Hospital
2022
Loughborough University
2000
AstraZeneca (United Kingdom)
2000
Walgreens Boots Alliance (United Kingdom)
1989
W.E. Upjohn Institute for Employment Research
1980
Glasgow Royal Infirmary
1923-1934
University of Glasgow
1934
Abstract Objective Arthritic synovial fluid (SF) contains mesenchymal stem cells (MSCs), which could simply reflect their shedding from diseased joint structures. This study used the bovine model to explore SF MSCs in health and enumerated them at earliest stages of human osteoarthritis (OA) radiographically normal joints. Methods Clonogenicity multipotentiality were compared with donor‐matched bone marrow (BM) single‐cell level. The colony‐forming unit–fibroblastic assay was for MSC...
Infection is the major reason for GTR/GBR membrane failure in clinical applications.
Bioactive glasses are known to stimulate bone healing, and the incorporation of strontium has potential increase their potency. In this study, calcium oxide in 45S5 bioactive glass composition was partially (50%, Sr50) or fully (100%, Sr100) substituted with on a molar basis. The effects substitution properties were studied, including density, solubility, vitro cytotoxicity. Stimulation osteogenic differentiation investigated using mesenchymal stromal cells obtained from rat marrow....
Introduction: Cannabinoids have shown to reduce joint damage in animal models of arthritis and matrix metalloproteinase expression primary human osteoarthritic (OA) chondrocytes. The actions cannabinoids are mediated by a number receptors, including cannabinoid receptors 1 2 (CB1 CB2), G-protein-coupled 55 18 (GPR55 GPR18), transient receptor potential vanilloid-1 (TRPV1), peroxisome proliferator-activated alpha gamma (PPARα PPARγ). However, date very few studies investigated the...
Abstract The TGF‐ β family ligand Nodal is an essential regulator of embryonic development, orchestrating key processes such as germ layer specification and body axis formation through activation SMAD2/3‐mediated signaling. Significantly, this requires the co‐receptor Cripto‐1. However, despite their roles in embryogenesis, molecular mechanism which Cripto‐1 enables to activate SMAD2/3 pathway has remained elusive. Intriguingly, also been shown antagonize other ligands, raising questions...
Cartilage defects are a major health problem. Tissue engineering has developed different strategies and several biomaterial morphologies, including natural-based ones, for repairing these defects. We used electrospun polycaprolactone (PCL) starch-compounded PCL (SPCL) nanofiber meshes to evaluate extracellular matrix (ECM) formation by bovine articular chondrocytes (BACs). The main aim of this work was the suitability SPCL in chondrocyte cultures, their capability produce ECM when seeded...
Hydrogel brushes are materials composed of a water-swollen network, which contains polymer chains that grafted with another polymer. Using thermally responsive polymer, poly( N -isopropyl acrylamide) (polyNIPAM), as the graft component we able to maintain critical solution temperature ( T crit ), independent overall composition material, at approximately 32°C. The change in swelling is function amount polyNIPAM system. However, there much smaller surface contact angles . PolyNIPAM-based have...
Articular cartilage injuries are frequently difficult to repair because of the poor regenerative capacity this tissue.
Novel chitosan/polybutylene succinate fibre-based scaffolds (C-PBS) were seeded with bovine articular chondrocytes in order to assess their suitability for cartilage tissue engineering. Chondrocytes onto C-PBS using spinner flasks under dynamic conditions, and cultured orbital rotation a total of 6 weeks. Non-woven polyglycolic acid (PGA) felts used as reference materials. Tissue-engineered constructs characterized by scanning electron microscopy (SEM), hematoxylin-eosin (H&E), toluidine...
ABSTRACT Fibroblasts are the major cellular component of connective tissue and experience mechanical perturbations due to matrix remodelling interstitial fluid movement. Transforming growth factor β1 (TGF‐β1) can promote differentiation fibroblasts in vitro a contractile myofibroblastic phenotype characterised by presence α‐smooth muscle actin (α‐SMA) rich stress fibres. To study role stimulation this process, we examined response primary human physiological levels movement its influence on...
Three novel borosilicate bioactive glasses (BBGs) of general formula 0.05Na2O·0.35x·0.20B2O3·0.40SiO2 (molar ratio, where x = MgO or CaO SrO) were prepared and used to investigate the effect crystallization on their properties including cytotoxicity. The three postmelt compositions determined using X-ray fluorescence spectroscopy, events studied differential thermal analysis diffraction. This information was determine heat treatments prepare glass-ceramics by controlled crystallization....