A5103226252- Gene expression and cancer classification
- Celiac Disease Research and Management
- Optimal Experimental Design Methods
- Statistical Methods in Clinical Trials
- Galectins and Cancer Biology
- Whipple's Disease and Interleukins
- Veterinary Equine Medical Research
- Molecular Biology Techniques and Applications
- Neuroblastoma Research and Treatments
- Spectroscopy and Chemometric Analyses
- Inflammatory Bowel Disease
- Chromatin Remodeling and Cancer
- Microscopic Colitis
- Tendon Structure and Treatment
- Tribology and Lubrication Engineering
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
Universidad Complutense de Madrid
2011-2020
Celiac disease (CD) is developed after gluten ingestion in genetically susceptible individuals. It can appear at any time life, but some differences are commonly observed between individuals with onset early life or adulthood. We aimed to investigate the molecular basis underlying those differences. collected 19 duodenal biopsies of children and adults CD compared expression 38 selected genes each other 13 non-CD controls matched by age. A Bayesian methodology was used analyze gene groups....
Background and aimTo diagnose coeliac disease (CD) in individuals on a gluten free diet (GFD), we aimed to assess the utility of detecting activated γδ CD8 T cells expressing gut-homing receptors after short challenge.MethodsWe studied 15 CD patients 35 non-CD controls, all exposed three days when following GFD. Peripheral blood was collected before six starting consumption, expression CD103, β7 CD38 assessed by flow cytometry. Determination IFN-γ IP-10 performed means ELISPOT and/or Luminex...
Abstract Autoimmune diseases like celiac disease (CeD) and ulcerative colitis (UC) show a common genetic background defined by the existence of shared susceptibility loci. We aimed to go deeper into this through performing cross‐disease study based on gene expression. measured expression 21 genes located in 13 CeD‐UC regions, 10 five CeD risk regions. Determinations were carried out colon/rectum samples from UC patients (inflamed uninflamed tissue) four colon controls. Duodenal 19 12...
A noninvasive method for visualizing lumbosacral nerves would be helpful horses with suspected plexopathy or injury. The aim of this prospective descriptive pilot study was to characterize the ultrasonographic appearance in a sample healthy horses, and expand on technique image acquisition. Horses were recruited inclusion if they determined sound based clinical lameness evaluation. Transrectal ultrasound images (L6, S1, S2) obtained both sides. Landmarks localization, techniques nerve...
Background: The CX3CL1–CX3CR1 axis has been related to numerous diseases. aim of our study was investigate its involvement in coeliac disease (CD) pathogenesis, particularly the early phase disease. Methods: We collected peripheral blood from CD patients and controls, enrolled a 3-day gluten challenge, soluble CX3CL1, I-TAC MIG by Luminex, CX3CL1 CX3CR1 gene expression qPCR, protein monocytes CD8+, CD4+ γδ+ T cells, flow cytometry. also analysed mRNA duodenal biopsies with active treated...
DNA microarray experiments require the use of multiple hypothesis testing procedures because thousands hypotheses are simultaneously tested. We deal with this problem from a Bayesian decision theory perspective. propose criterion based on an estimation number false null (FNH), taking as error measure proportion posterior expected positives respect to estimated true hypotheses. The methodology is applied Gaussian model when bilateral procedure illustrated both simulated and real data examples...
Recently, the field of multiple hypothesis testing has experienced a great expansion, basically because new methods developed in genomics. These allow scientists to simultaneously process thousands tests. The frequentist approach this problem is made by using different error measures that control Type I rate at certain desired level. Alternatively, article, Bayesian hierarchical model based on mixture distributions and an empirical Bayes are proposed order produce list rejected hypotheses...
Many experiments require simultaneously testing many hypotheses. This is particularly relevant in the context of DNA microarray experiments, where it common to analyze genes determine which them are differentially expressed under two conditions. Another important problem this how model dependence at level gene expression. In paper, we propose a Bayesian procedure for multiple hypotheses, modeling through copula functions, all available information, both objective and subjective, can be used....