A5063374760- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Acute Ischemic Stroke Management
- Whipple's Disease and Interleukins
- Neurological Disease Mechanisms and Treatments
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Celiac Disease Research and Management
- Neurological Disorders and Treatments
- Nerve injury and regeneration
- Microscopic Colitis
Lund University
2022-2025
Hospital Clínico San Carlos
2018
Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
2018
Ischemic stroke is a leading cause of death and disability worldwide, with its prevalence significantly increasing among the aging population. The process linked to several physiological changes that increase risk ischemic stroke. This review summarizes mechanisms clarify why more common in elderly, how demographics are expected change an population, what strategies can be implemented enhance prevention, acute care, post-stroke rehabilitation for older adults. Emphasis placed on importance...
ABSTRACT Intracerebral transplantation of stem cell-derived oligodendrocytes (OLs) holds promise as a new strategy for repairing demyelinated brain tissue. However, two challenges hinder clinical translation: the slow and inefficient generation human OLs using protocols described to date, limited insight into their remyelination potential, which has only been evaluated in vitro or xenotransplantation studies, failing capture critical human-specific cellular interactions involved myelination....
Ischemic stroke, a leading cause of death and disability worldwide, frequently results in cortical damage. Due to disrupted neural connectivity, lesions often trigger secondary neurodegeneration remote brain regions, such as the thalamus. This thalamic injury exacerbates neurological deficits, long-term sensory, motor, cognitive impairments. Although animal models have demonstrated that damage is driven by retrograde degeneration, excitotoxicity, apoptosis, blood-brain barrier disruption,...
Neuronal loss and axonal demyelination underlie long-term functional impairments in patients affected by brain disorders such as ischemic stroke. Stem cell-based approaches reconstructing remyelinating neural circuitry, leading to recovery, are highly warranted. Here, we demonstrate the vitro vivo production of myelinating oligodendrocytes from a human induced pluripotent stem cell (iPSC)-derived neuroepithelial (lt-NES) line, which also gives rise neurons with capacity integrate into...
Background and aimTo diagnose coeliac disease (CD) in individuals on a gluten free diet (GFD), we aimed to assess the utility of detecting activated γδ CD8 T cells expressing gut-homing receptors after short challenge.MethodsWe studied 15 CD patients 35 non-CD controls, all exposed three days when following GFD. Peripheral blood was collected before six starting consumption, expression CD103, β7 CD38 assessed by flow cytometry. Determination IFN-γ IP-10 performed means ELISPOT and/or Luminex...
ABSTRACT Stroke is a major cause of long-term disability in adult humans, the neuronal loss leading to motor, sensory, and cognitive impairments. Replacement dead neurons by intracerebral transplantation stem cell-derived for reconstruction injured networks has potential become novel therapeutic strategy promote functional recovery after stroke. Here we describe rapid efficient protocol generation cortical via direct programming human embryonic (hES) cells. Our results show that 7 days...
SUMMARY Neuronal loss and axonal demyelination underlie long-term functional impairments in patients affected by brain disorders such as ischemic stroke. Stem cell-based approaches reconstructing remyelinating neural circuitry, leading to recovery, are highly warranted. Here we demonstrate the vitro vivo production of myelinating oligodendrocytes from a human induced pluripotent stem (iPS) cell-derived neuroepithelial (lt-NES) cell line, which also gives rise neurons with capacity integrate...
Neurodegenerative disorders are common and heterogeneous in terms of their symptoms cellular affectation, making study complicated due to the lack proper animal models that fully mimic human diseases poor availability post-mortem brain tissue. Adult nervous tissue culture offers possibility different aspects neurological disorders. Molecular, cellular, biochemical mechanisms could be easily addressed this system, as well testing validating drugs or treatments, such cell-based therapies. This...
Neurodegenerative disorders are common and heterogeneous in terms of their symptoms cellular affectation, making study complicated due to the lack proper animal models that fully mimic human diseases poor availability post-mortem brain tissue. Adult nervous tissue culture offers possibility different aspects neurological disorders. Molecular, cellular, biochemical mechanisms could be easily addressed this system, as well testing validating drugs or treatments, such cell-based therapies. This...