A5008615346- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Multiple Myeloma Research and Treatments
- Chromatin Remodeling and Cancer
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Genomics and Chromatin Dynamics
- Sinusitis and nasal conditions
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Cancer-related gene regulation
- Chemokine receptors and signaling
- Forensic Toxicology and Drug Analysis
- Phytoplasmas and Hemiptera pathogens
- Marine Toxins and Detection Methods
- Immunotherapy and Immune Responses
- Nicotinic Acetylcholine Receptors Study
- HIV Research and Treatment
- Cancer Research and Treatments
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2024
Children's Hospital of Philadelphia
2016-2019
University of Pennsylvania
2016-2019
Lafayette College
2006-2007
Cawthron Institute
2007
Global changes in chromatin organization and the cessation of transcription during mitosis are thought to challenge resumption appropriate patterns after mitosis. The acetyl-lysine binding protein BRD4 has been previously suggested function as a transcriptional "bookmark" on mitotic chromatin. Here, genome-wide location analysis erythroid cells, combined with data normalization peak characterization approaches, reveals that widely occupies However, removal from does not impair post-mitotic...
Abstract A collaborative study was conducted on the Biosense amnesic shellfish poisoning (ASP) enzyme-linked immunosorbent assay (ELISA) for determination of domoic acid (DA) toxins in order to obtain interlaboratory validation data method. In addition, a method comparison performed evaluate ASP ELISA as an alternative current liquid chromatography (LC) reference DA determination. The material comprised 16 samples, including blue mussels, Pacific oysters, and king scallops, spiked with...
The widely expressed bromodomain and extraterminal motif (BET) proteins bromodomain-containing protein 2 (BRD2), BRD3, BRD4 are multifunctional transcriptional regulators that bind acetylated chromatin via their conserved tandem bromodomains. Small molecules target BET bromodomains being tested for various diseases but typically do not discern between family members. Genomic distributions partners of have been described, the basis differences in function within a given lineage remains...
To delineate whether, and the extent to which, CCL5 could impact T cell function we examined cytokine production proliferative ability following treatment in vitro. We report a decreased of splenic cells produce IFN-? TNF-a as well proliferate response crosslinking with antibody CD3 after 72, but not 24 hours exposure. identify mechanism by which modulated function, receptor translocation lipid raft clustering. After exposure CCL5, were less efficient at translocating TCR clustering rafts....
Abstract A previous study showed that reducing tumor-derived CCL5 expression using RNA interference did not significantly influence growth rate or metastatic ability of the 4T1 tumor. Since is an aggressive tumor constitutively expresses and exhibits low immunogenicity we wanted to determine whether derived could disease progression a less non-metastatic For this purpose used 168 which does express CCL5. We cloned full length gene, inserted it into eukaryotic vector transfected Whereas...