A5110847559- Gut microbiota and health
- Osteomyelitis and Bone Disorders Research
- Metabolomics and Mass Spectrometry Studies
- Orthopedic Infections and Treatments
- Heterotopic Ossification and Related Conditions
- Ginseng Biological Effects and Applications
- Tryptophan and brain disorders
- Traditional Chinese Medicine Studies
- Diet and metabolism studies
- Respiratory viral infections research
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Dietary Effects on Health
- Thermoregulation and physiological responses
- Complementary and Alternative Medicine Studies
- Inflammasome and immune disorders
- Infrared Thermography in Medicine
- Nutrition, Genetics, and Disease
- Clostridium difficile and Clostridium perfringens research
- Endometriosis Research and Treatment
- Inflammatory Bowel Disease
- Immune Response and Inflammation
- Anesthesia and Pain Management
- Pediatric health and respiratory diseases
- Berberine and alkaloids research
Beijing University of Chinese Medicine
2014-2024
Shanghai Electric (China)
2022
Chenzhou First People's Hospital
2021
China-Japan Friendship Hospital
2017
Aristolochic acid (AA) has been reported to cause a series of health problems, including aristolochic nephropathy and liver cancer. However, AA-containing herbs are highly safe in combination with berberine (Ber)-containing traditional medicine, suggesting the possible neutralizing effect Ber on toxicity AA. In present study,
Meditation has been widely used for the treatment of a variety psychological, cardiovascular, and digestive diseases as well chronic pain. Vegetarian diets can effectively prevent hypertension, metabolic such diabetes obesity, certain cancers. vegetarian have recognized components healthy lifestyle therefore attracted more people around world. help regulate overall health through neural-endocrine-immune network. Changes in dietary habits affect composition intestinal flora, which turn...
To explore changes in the gut microbiota (GM), urine metabolome and plasma proteome individuals with allergies using multiomics analyses, identify key components mechanism.This was a cross-sectional study. All subjects were recruited to collect fecal, blood samples. 16S rDNA sequencing used analyze structure function of GM, liquid chromatography mass spectrometry quantify metabolites urine, data-independent acquisition quantitative analysis detect proteins plasma. Differences between...
Background: Recurrent respiratory tract infections (RRTIs) have a negative impact on both children's health and family wellbeing.Deficiency of ZhengQi used to be an instinct factor driving RRTI in Traditional Chinese Medicine (TCM).Our clinical observations suggest that children with gastrointestinal heat retention syndrome (GHRS) may greater risk catching (RTIs).GHRS is new predisposing for it dietary related.This study aimed explore association between GHRS RRTI.Methods: A prospective...
Objective This study aims to investigate the pathogenesis of hyperglycemia and its associated vasculopathy using multiomics analyses in diabetes impaired glucose tolerance, validate mechanism cell experiments. Methods In this study, we conducted a comprehensive analysis metagenomic sequencing data explore key genera related occurrence. Subsequently, participants diagnosed with tolerance (IGT), healthy subjects, were recruited for fecal blood sample collection. The dysbiosis gut microbiota...
Gastrointestinal heat retention syndrome (GHRS) refers to a condition that is associated with increased gastrointestinal caused by metabolic block in energy. It common children and closely related the occurrence development of recurrent respiratory tract infection, pneumonia, functional abdominal pain, etc. However, there are no standardized diagnostic criteria differentiate GHRS. Therefore, this study aimed establish model for children's GHRS explore possible biological basis using systems...
To explore the structural and functional characteristics of fecal-associated microbiome (FAM) in a traditional Chinese medicine (TCM) qi-deficiency constitution (QDC) by comparing with balanced (BC) screen related biomarkers. In this cross-sectional study, TCM constitutions subjects were determined based on published Classification Determination further confirmed clinician. Clinical recorded, fecal samples collected for 16S rDNA sequencing using Illumina Miseq platform. The FAM structure was...
Objective This study aimed to investigate the diagnostic value and underlying mechanisms of sialic acid-binding Ig-like lectin 9 (SIGLEC9) in gliomas. Patients Methods The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases were used analyze association SIGLEC9 expression levels with tumor stages survival probability. Immunohistochemical staining analysis performed 177 glioma patients. Furthermore, related discovered about tumorigenesis, we reveal how functions macrophages through...
Background: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare disease that characterized by autoinflammatory lesions on both bones skin. The diverse manifestations limited understanding of its etiology have hindered the diagnosis treatment this condition. SAPHO also classified as primary inflammatory osteitis. onset osteoarticular involvement in typically gradual, identification associated biomarkers may be crucial for accurate diagnosis, effective treatment,...
Abstract Background Shaoyao Decoction (SYD) is a widely recognized herbal formula utilized in traditional Chinese medicine for the treatment of diarrhea. Although it has demonstrated significant effectiveness clinical practice treating ulcerative colitis, precise mechanisms by which operates remain largely elusive. Methods The active ingredients SYD were obtained ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), used to explore potential pharmacological mechanism...
The Shenghua Decoction recorded in Fu Qing Zhu's Gynaecology,is a commonly used postpartum prescription,widely treating and gynecological diseases. However,its mechanism of action lower abdominal pain remains unclear. In this paper,network pharmacology was to explore the treatment abdomen pain,so as provide data support for better clinical application Decoction. drug targets were retrieved SymMap. String Cytoscape adopted enrichment analysis construct disease-drug-target biological network....
To examine the effects of accumulated heat in GI tract (AHGIT) on lung tissue protein expression pneumonic mice. Nebulized lipopolysaccharides (LPS) were administered to induce a mouse model (M1), and high-calorie/protein diet combined with nebulized LPS was used AHGIT pneumonia (M2). Isobaric tag for relative absolute quantitation (iTRAQ) proteomics applied study expression, followed by bioinformatics analysis. M1 mice developed alveolar damage prominent septum thickening, vascular...
Susceptibility to lipid metabolic dysfunction are more frequent in individuals with dampness-heat (DH) constitution, which might be caused by the changes gut microbiome. This study is explore structural and functional characteristics of fecal-associated microbiome (FAM) DH constitution screen FAM-related biomarkers constitution. Fecal samples were collected. The FAM structure was described alpha/beta diversity indexes relative abundances dominant taxa; distribution/functional differences...
Abstract Background SAPHO syndrome is a group of symptoms consisting synovitis, acne, pustulosis, hyperostosis and osteosis. There no specific laboratory index assist in the diagnosis because its highly heterogeneous clinical manifestations. Pathogenic microorganisms had been identified biopsies some cases particular gene mutations were also linked to occurrence SAPHO. It largely unknown whether intestinal microbiome plays role pathogenesis To explore structure syndrome, fecal samples from...
To investigate whether the specific traditional Chinese medicine (TCM) constitution of individuals can be defined by certain biological indexes instead answering questionnaire, and to explore possibility discriminating nine TCM constitutions from each other simultaneously using indexes. Blood urine samples 152 with were collected, related analyzed combining ANOVA, multiple comparison, discriminant analysis, support vector machine. We found that 4 out 24 blood routine indexes, 7 10 12 32...
To search for specific metabolites in the lungs of pneumonia rats fed with a high-calorie diet, as well explore changes lung young treated Yinlai Decoction (YD) and its effects on inflammation-related metabolic pathways. Lipopolysaccharides (LPS) special diet were used to induce Sprague Dawley (SD) simulate intestinal state infant pneumonia. Liquid chromatography-mass spectrometry technology (LC-MS/MS) was detect each group. Supervised orthogonal partial least squares discriminant analysis...
Purpose: Unexplained chronic fatigue (CF) is common symptom in worldwide. According to the theory of Korean Medicine (KM), CF considered be imbalance interorgan functions or four essential components human body, including qi, blood, yin and yang. Thus appears have individual differences, it can subdivided into different pattern identification (PI) for a personalized diagnosis KM. However, there are no diagnostic tools, such as questionnaires medical devices. The purpose this studywas develop...
This study aims to investigate the molecular mechanism and identify potential drugs for subthreshold depression (SD). Danzhi Xiaoyao powder (DZXY), a traditional Chinese medicine, is widely used treat has demonstrated excellent efficacy. However, detailed of SD treatment remains unclear; thus, we explored curative DZXY in SD. Using RNA-sequencing, identified differentially expressed genes (DEGs) leukocytes compared healthy controls, deciphered their functions pathways, hub We also assessed...