A5008923951- Lipid Membrane Structure and Behavior
- Computational Drug Discovery Methods
- Bee Products Chemical Analysis
- Biochemical and Molecular Research
- SARS-CoV-2 and COVID-19 Research
- Electrochemical Analysis and Applications
- Insect and Pesticide Research
- Fermentation and Sensory Analysis
- Calcium Carbonate Crystallization and Inhibition
- Chromium effects and bioremediation
- X-ray Diffraction in Crystallography
- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Crystallization and Solubility Studies
- Spectroscopy and Quantum Chemical Studies
- Isotope Analysis in Ecology
- Folate and B Vitamins Research
- Clay minerals and soil interactions
- COVID-19 epidemiological studies
- Metal Extraction and Bioleaching
- Statistical Mechanics and Entropy
- Heavy Metals in Plants
- Glycosylation and Glycoproteins Research
- Metabolism and Genetic Disorders
- Phosphorus and nutrient management
Alliance for Public Health
2021
The Research Council
2015
University of Iowa
2007-2009
Jackson Laboratory
2009
KineMed (United States)
2009
Baylor College of Medicine
2009
Emory University
2009
Indiana University
2009
Amyotrophic Lateral Sclerosis Therapy Development Institute
2009
Loyola University Chicago
2006
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires better stratification of patients for the development drug trials and care. In this study we explored through crowdsourcing approach, DREAM Prize4Life ALS Stratification Challenge. Using data from >10,000 1479 community-based patient registers, more than 30 teams developed new approaches machine learning clustering, outperforming best current...
An essential overview of the biological role coronavirus viroporin (envelope protein) is given, together with effect its known inhibitors on life cycle coronavirus. A docking study conducted using a set drugs approved worldwide (ca. 6000 compounds) structure SARS-CoV-2 modelled from published NMR-resolved structures. The screening has identified 36 promising currently market, which could be proposed for pre-clinical trials.
Forensic application of carbon isotope ratio measurements honey and protein to investigate the degree adulteration with high fructose corn syrup or other C4 plant sugars is well established. These must use methods that exhibit suitable performance criteria, particularly regard measurement uncertainty traceability - low levels can only be detected by result in suitably small uncertainties such differences 1‰ less reliably detected. Inter-laboratory exercises are invaluable assess state-of-the...
In the last several years, economically motivated adulteration (EMA) of foods including honey has received increased attention. The addition inexpensive sweeteners such as high fructose corn syrup or cane sugar to is still encountered despite scientific methods that can routinely detect this type adulteration. standard method for detection these adulterants utilizes isotope ratio mass spectrometry (IRMS); however, technique requires an elevated degree technical knowledge operation well a...
Flavin-dependent thymidylate synthases (FDTS) catalyze the production of dTMP from dUMP and N(5),N(10)-methylene-5,6,7,8-tetrahydrofolate (CH(2)H(4)folate). In contrast to human other classical synthases, activity FDTS depends on a FAD coenzyme, its catalytic mechanism is very different. Several pathogens rely this recently discovered enzyme, making it an attractive target for novel antibiotics. Like many flavoenzymes, can function as oxidase, which catalyzes reduction O(2) H(2)O(2), using...
New findings lead to a revised understanding of the substrates' binding order, role substrate as an activator, and observed lag phase in FDTS catalyzed reaction.
Background: Economically motivated adulteration (EMA) of foods has become an increasing concern in recent years, with lemon juice as a popular target. Objective and Method: In this work, optimized preparation procedure for the isolation citric acid from was validated using elemental analyzer-isotope ratio MS (EA-IRMS) to detect exogenous acid. Additionally, 69 imported samples were evaluated combustion module-cavity ring down spectrometry (CM-CRDS) compared well-established EA-IRMS....
The results of flame (FAAS) or graphite furnace atomic absorption spectrometric (GFAAS) analyses are presented and discussed on the accumulation essential metals (Mg, Ca, Mn Fe contained in cultivation medium) traces each one conventionally xenobiotic elements from group V, Co, Ni, Cu, Zn Pb, added to medium concentrations (0.2 mM) which do not essentially suppress growth bacterial culture, cells plant root-associated nitrogen-fixing bacterium Azospirillum brasilense. Along with cations...
An essential overview of the biological role coronavirus viroporin (envelope protein) is given, together with effect its known inhibitors on life cycle coronavirus. A docking study conducted using a set drugs approved worldwide (ca. 6000 compounds) structure SARS-CoV-2 modelled from published NMR-resolved structures. The screening has identified 36 promising currently market, which could be proposed for pre-clinical trials.
New Zealand manuka honeys are known for their propensity to increase apparent C4 sugar content during storage. Depending on the particular storage regime and initial of dihydroxyacetone (DHA) in honey, ready-to-market product often fails test because above phenomenon. We have used DHA labeled with a radioactive 14C isotope set subject an incubation experiment. These were analyzed DHA, methylglyoxal (MG), hydroxymethylfurfural (HMF), sugars, scintillation counts over period 18 months. The...
Abstract The mineral coating of Dyerophytum indicum Kuntze (Plumbaginaceae) was analyzed by isotope ratio mass spectrometry, X-ray diffraction, thermogravimetric and differential thermal analysis, scanning electron microscopy/energy-dispersive spectroscopy methods. Its composition found to be similar those the carbonate mixtures isolated from rotting cacti speleothems. consisted three major phases (monohydrocalcite, nesquehonite, calcite), a minor phase hydromagnesite, traces silica sylvite....
Abstract Herewith we present a computational model for the forecasting of cumulative diagnosed cases Covid-19 pneumonia within country. The only explicit parameter is population density. implicit moving average ambient temperature, currently integrated into kinetic constants. Other finer details pertaining to mechanism pathogen SARS-CoV-2 spread given region are implicitly manifested in exponent parameters derived from non-linear fitting published data on occurrence. performance demonstrated...
Thanks to the organizers for providing this forum and speaker his stimulating talk.Question 1 -what is your opinion on timing of dosing regimen with regard ALS mouse model study design?Specifically, please provide a rationale presymptomatic as opposed beginning treatment following onset symptoms.Should not all preclinical testing be performed agent given after symptoms more accurately reflect clinical scenario?This especially relevant elegant studies by Dr. Cleveland which show that...
<h3>Background/Purpose</h3> Restrictions of COVID-19 pandemic have made it more difficult to provide HIV testing and PrEP services MSM in large Ukrainian cities. The purpose the intervention is maintain effectiveness provision these during implement new/innovative mobile interventions this regard. <h3>Approach</h3> methodology consists conducting two national campaigns aimed at recruiting 3 largest cities Ukraine, for HIV/STI/HCV testing, as well attract program, through targeted advertising...