A5041430992- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Nutritional Studies and Diet
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Blood Pressure and Hypertension Studies
- Advanced MRI Techniques and Applications
- Pancreatitis Pathology and Treatment
- Cardiovascular Disease and Adiposity
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Herpesvirus Infections and Treatments
- Reproductive tract infections research
- Menopause: Health Impacts and Treatments
- Tryptophan and brain disorders
- Neurological Disease Mechanisms and Treatments
- Food Security and Health in Diverse Populations
- Stroke Rehabilitation and Recovery
- Neurogenetic and Muscular Disorders Research
- Artificial Intelligence in Healthcare
Boston University
2018-2024
Framingham Heart Study
2020-2024
Fred Hutch Cancer Center
2024
New York University
2022
Institute for Neurodegenerative Disorders
2022
The University of Texas Health Science Center at San Antonio
2022
University of California, Davis
2022
Ollscoil na Gaillimhe – University of Galway
2022
Health First
2022
Harvard University
2022
Advances in molecular positron emission tomography (PET) have enabled anatomic tracking of brain pathology longitudinal studies normal aging and dementia, including assessment the central model Alzheimer's disease (AD) pathogenesis, according to which TAU begins focally but expands catastrophically under influence amyloid-β (Aβ) mediate neurodegeneration cognitive decline. Initial deposition occurs many years before Aβ a specific area medial temporal lobe. Building on recent work that focus...
Loneliness is common, and its prevalence rising. The relationship of loneliness with subsequent dementia the early preclinical course Alzheimer disease related (ADRD) remains unclear. Thus, primary objective this study was to determine association 10-year all-cause risk cognitive neuroanatomic imaging markers ADRD vulnerability.
Women have a higher lifetime risk of Alzheimer's disease (AD) than men. Among cognitively normal (CN) older adults, women exhibit elevated tau positron emission tomography (PET) signal compared with We explored whether menopause exacerbates sex differences in deposition middle-aged adults.328 CN participants from the Framingham Study (mean age = 57 years (±10 years), 161 women, whom, 104 were post-menopausal) underwent and β-amyloid (Aβ)-PET neuroimaging. examined global Aβ-PET, tau-PET 5...
The association between vascular risk factors and dementia varies with age, making generalizability of prediction rules to individuals different ages challenging. We determined the most important for inclusion in age-specific scores.
<h3>Importance</h3> Cognitive resilience refers to the general capacity of cognitive processes be less susceptible differences in brain structure from age- and disease-related changes. Studies suggest that supportive social networks reduce Alzheimer disease related disorder (ADRD) risk by enhancing resilience, but data on specific support mechanisms are sparse. <h3>Objective</h3> To examine association individual forms with a global neuroanatomical measure early ADRD vulnerability cognition....
Background: Adherence to the Mediterranean-DASH for Neurodegenerative Delay (MIND) diet has previously been associated with cognitive decline and dementia. To our knowledge, no prior study investigated association between MIND measures of brain volume, silent infarcts (SBIs), or atrophy. Objective: We evaluated whether adherence superior function, larger volumes, fewer SBIs, less in community-based Framingham Heart Study. Methods: 2,092 participants (mean±SD, age 61±9) completed Food...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires better stratification of patients for the development drug trials and care. In this study we explored through crowdsourcing approach, DREAM Prize4Life ALS Stratification Challenge. Using data from >10,000 1479 community-based patient registers, more than 30 teams developed new approaches machine learning clustering, outperforming best current...
The duration and lifetime pattern of hypertension is related to risk stroke dementia. In turn, cerebral small vessel disease (CSVD) the most frequent form cerebrovascular underlying dementia stroke. Thus, study relation mid late life trends with CSVD in will help understand hypertension’s role inform preventive efforts consequences. We studied 1686 Framingham Heart Study Offspring cohort participants free dementia, who were examined life, had available brain magnetic resonance imaging during...
Background: Liver steatosis and fibrosis are emerging as risk factors for multiple extrahepatic health conditions; however, their relationship with Alzheimer’s disease pathology is unclear. Objective: To examine whether non-alcoholic fatty liver (NAFLD) FIB-4, a non-invasive index of advanced fibrosis, associated brain amyloid-β (Aβ) tau pathology. Methods: The study sample included Framingham Study participants from the Offspring Third generation cohorts who attended exams 9 (2011–2014) 2...
Plasma phosphorylated-tau181 (p-tau181) is a promising biomarker for Alzheimer's disease (AD) and may offer utility predicting preclinical disease.
Aortic stiffness is associated with clinical hallmarks of Alzheimer disease and related dementias could be a modifiable target for prevention.To assess associations aortic pressure pulsatility global amyloid-β plaques regional tau burden in the brain middle-aged older adults without dementia.The sample this cross-sectional study was drawn from Framingham Heart Study Third Generation Cohort at examination 3 (N = 3171; 2016-2019), whom 3092 successfully underwent comprehensive hemodynamic...
Previous studies suggest poor pulmonary function is associated with increased burden of cerebral white matter hyperintensities and brain atrophy among elderly individuals, but the results are inconsistent.To study cross-sectional associations structural variables.Data from six large community-based samples (N = 11,091) were analyzed. Spirometric measurements standardized respect to age, sex, height, ethnicity using reference equations Global Lung Function Initiative. Associations forced...
Background: An association between chronic infectious diseases and development of dementia has been suspected for decades, based on the finding pathogens in postmortem brain tissue serological evidence. However, questions remain regarding confounders, reverse causality, how accurate, reproducible generalizable those findings are. Objective: Investigate whether exposure to Herpes simplex (manifested as herpes labialis), Chlamydophila pneumoniae (C. pneumoniae), Helicobacter pylori (H....
Normal cardiac function is directly associated with the maintenance of cerebrovascular health. Whether Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet, designed neurocognitive health, remodelling unknown. We evaluated 2512 Framingham Offspring Cohort participants who attended eighth examination cycle and had available dietary echocardiographic data (mean age 66 years; 55 % women). Using multivariable regression, we related cumulative...
Background: Depressive symptoms predict increased risk for dementia decades before the emergence of cognitive symptoms. Studies in older adults provide preliminary evidence an association between depressive and amyloid-β (Aβ) tau accumulation. It is unknown if similar alterations are observed midlife when preventive strategies may be most effective. Objective: The study aim was to evaluate cerebral Aβ a predominately middle-aged cohort with examination apolipoprotein (APOE) ɛ4 allele as...
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined associations common genetic variants with verbal short-term and learning adults without dementia or stroke (N = 53,637). We identified novel loci intronic region CDH18, at 13q21 3p21.1, as well an expected signal APOE/APOC1/TOMM40 region. These results replicated independent sample. Functional bioinformatic analyses supported many these further implicated POC1. showed...
Background: Bone mineral density (BMD) is a potential surrogate marker of lifetime estrogen exposure previously linked to increased risk Alzheimer dementia among elderly women. We examine the association between BMD in “young old” with imaging biomarkers brain aging and cognitive performance. Methods: Offspring participants (N=1905, mean age 66) population-based cohort who had BMD, detailed assessment were included study. Sex-stratified, linear, logistic regression models used for analysis....
Abstract INTRODUCTION Understanding early neuropathological changes and their associations with cognition may aid dementia prevention. This study investigated of cerebral amyloid tau positron emission tomography (PET) retention in a predominately middle‐aged community‐based cohort examined factors that modify these relationships. METHODS 11 C‐Pittsburgh compound B 18 F‐flortaucipir PET imaging were performed. Associations evaluated using linear regression. Interactions age, apolipoprotein E...
Background Direct-acting antivirals (DAA) are highly effective at treating Hepatitis C virus (HCV) infection, with a cure rate >95%. However, the effect of DAAs on kidney function remains debated. Methods We analyzed electronic health record data for DAA-naive patients chronic HCV infection engaged in care Boston Medical Center between 2014 and 2018. compared following hypothetical interventions using causal inference methods: 1) initiation DAA 2) no initiation. For normal baseline...
To examine the relationship between blood pressure change and amyloid- tau-PET abnormalities in cognitively healthy adults.
Background: Loneliness has been declared an “epidemic” associated with negative physical, mental, and cognitive health outcomes such as increased dementia risk. Less is known about the relationship between loneliness advanced neuroimaging correlates of Alzheimer’s disease (AD). Objective: To assess whether was markers AD using data from Framingham Heart Study (FHS) participants without dementia. Methods: In this cross-sectional observational analysis, we used functional connectivity MRI...