A5066175452- Epigenetics and DNA Methylation
- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Heart Failure Treatment and Management
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Potassium and Related Disorders
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Issues in Pregnancy
- Diet and metabolism studies
- Cardiovascular Health and Risk Factors
- Pregnancy and preeclampsia studies
- Lipid metabolism and disorders
- Folate and B Vitamins Research
- Health, Environment, Cognitive Aging
- Blood Pressure and Hypertension Studies
- Diet, Metabolism, and Disease
- Adolescent and Pediatric Healthcare
- Sleep and related disorders
- Obesity, Physical Activity, Diet
- Maternal and fetal healthcare
- Birth, Development, and Health
Soochow University
2019-2022
Although elevated uric acid is associated with obesity and considered a predictor of hypertension, the causal linkage between three metabolic conditions not very clear. We aim to examine whether mediates effects on hypertension development.A total 1984 participants (mean aged 53 years, 62.10% female) repeated measurements obesity, blood pressure, 4 years apart in Gusu cohort were included. first applied cross-lagged panel analysis bidirectional association delineate temporal hyperuricemia....
As a key enzyme of the natriuretic peptides system, corin may participate in development cardiovascular disease (CVD). Its level circulation predicted CVD recurrence patients with myocardial infarction and heart failure, but no study examined this prediction general populations.This sought to examine prospective association between community-based population Chinese adults.The Gusu cohort included 2,498 participants (mean age 53 years, 39% men) who were free at baseline. Serum was measured...
Abstract Background Atrial natriuretic peptide (ANP), one of the main members peptides system, has been associated with hypertension and related complications, but underlying molecular mechanisms are not very clear. Here, we aimed to examine whether DNA methylation, a modification genome, A gene ( NPPA ), coding ANP, was hypertension. Methods Peripheral blood methylation promoter quantified by target bisulfite sequencing in 2498 community (mean aged 53 years, 38% men) as discovery sample...
Poor sleep quality is becoming very common in a developed society and relates to many health disorders. However, the association between hypertension has not been well studied Chinese adults.Blood pressure was measured assessed by Pittsburgh Sleep Quality Index (PSQI) for 5167 participants (mean aged 51±15 years, 41.5% males) Tianning Cohort. A logistic regression model constructed examine quality, as its components, hypertension, adjusting age, sex, education level, current smoking,...
Furin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association not yet studied Chinese. Here, we aimed to examine the between serum furin and fasting Chinese adults.Serum plasma were assayed for 2,172 participants (mean aged 53 years, 38% men) Gusu cohort. A median regression model was applied glucose, adjusting age, sex, education level, cigarette smoking, alcohol drinking, obesity, blood pressure, lipids. To facilitate data...
High blood pressure during pregnancy has been suggested to be associated with adverse birth outcomes (ABO), but it is unclear how different changes and the extent of effect. Therefore, we aimed investigate association between trajectories (systolic (SBP), diastolic (DBP), mean arterial (MAP), pulse (PP)) pregnant women ABO in a real-world study.Leveraging 28,679 their fetuses from register-based cohort January 1, 2010, December 31, 2019. Blood were estimated by package "traj" R software...
Although hyperuricemia, microalbuminuria, and hypertension are highly correlated, their temporal relationship is largely unknown. We aimed to examine whether microalbuminuria mediated the association between hyperuricemia hypertension.Leveraging a longitudinal cohort including 1981 Chinese adults who had blood pressures, urinary albumin creatinine ratio (UACR), uric acid measured twice 4 years apart, we examined relationships among by cross-lagged panel analysis followed causal mediation...
<b><i>Introduction:</i></b> Atrial natriuretic peptide plays a potential role in obesity with unclear molecular mechanisms. The objective of this study was to examine the association between its coding gene (<i>natriuretic A</i> [<i>NPPA</i>]) methylation and obesity. <b><i>Methods:</i></b> Peripheral blood DNA <i>NPPA</i> promoter quantified at baseline by targeted bisulfite sequencing for 2,497 community...
Corin, a physical activator of atrial natriuretic peptide, has been associated with hypertension unclear mechanisms. Here, we aimed to examine whether CORIN gene methylation was involved in the underlying molecular mechanisms.DNA levels were measured by target bisulfite sequencing using genomic DNA isolated from peripheral blood mononuclear cells 2498 participants Gusu cohort (discovery sample) and 1771 independent (replication sample). We constructed mediation model as predictor, serum...
Abstract Objectives: Furin has been associated with hypertension through unclear underlying mechanisms. FURIN promoter methylation may participate in the mechanisms, but no evidence supports this possibility. Here, we performed a prospective analysis to study association between and incident hypertension. Methods: DNA levels were quantified by target bisulfite sequencing using peripheral blood from 1043 participants Gusu cohort (mean age: 50 years, 30% men) who free of at baseline. After an...
Hypothesis: Corin protein, a physiological activator of the atrial natriuretic peptide, has been associated with hypertension unclear mechanisms. Its coding gene methylation may be involved in underlined mechanisms but no evidence. Objectives: We aimed to examine 1) whether CORIN was and 2) this association mediated by corin protein. Methods: As illustrated following picture, peripheral blood DNA promoter quantified targeted bisulfite sequencing 2,498 community members (mean aged 53 years,...