A5103089277- Advanced Glycation End Products research
- Natural Compounds in Disease Treatment
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Traditional Chinese Medicine Studies
- Chronic Kidney Disease and Diabetes
- Ginkgo biloba and Cashew Applications
- Cytomegalovirus and herpesvirus research
- Biochemical and Molecular Research
- Laser Applications in Dentistry and Medicine
- Biochemical Acid Research Studies
- MRI in cancer diagnosis
- Systemic Sclerosis and Related Diseases
- Lipid metabolism and disorders
- Renal and Vascular Pathologies
- Advanced Neuroimaging Techniques and Applications
- Biological Research and Disease Studies
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- Pharmacological Effects of Natural Compounds
- Central Venous Catheters and Hemodialysis
- Diagnosis and treatment of tuberculosis
- Acute Kidney Injury Research
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Health and Disease Prevention
Beijing Hospital
2012-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2023
Sixth Affiliated Hospital of Kunming Medical University
2008
Background . Diabetic nephropathy (DN) is a major cause of chronic kidney disease (CKD). There are no effective treatments to prevent or reverse the progression DN. A preliminary study showed that Tripterygium glycosides from wilfordii Hook F (TwHF) with valsartan decrease proteinuria in patients Objectives The objective present investigate efficacy and safety TwHF, traditional Chinese medicine, for treatment Methods Analysis This prospective, single-center randomized controlled trial....
We used a sensitive and accurate method based on isotope dilution high-performance liquid chromatography–triple quadrupole mass spectrometry (ID-LC-MS/MS) to determine the levels of 8-oxo-7,8-dihydro-2-deoxyguanosine (8-oxo-dGsn) 8-oxo-7,8-dihydroguanosin (8-oxo-Gsn) in various tissue specimens, plasma, urine hyperglycemic Sprague Dawley rats induced by streptozotocin (STZ). The oxidative DNA RNA damages were observed organs amounts 8-oxo-dGsn 8-oxo-Gsn derived from increased with status. In...
To evaluate RNA oxidation in the early stage of diabetic nephropathy, we applied an accurate method based on isotope dilution high‐performance liquid chromatography‐triple quadruple mass spectrometry to analyze oxidatively generated guanine nucleosides renal tissue and urine from db/db mice different ages. We further investigated relationship between these oxidative stress markers, microalbumin excretion, histological changes. found that levels 8‐oxo‐7,8‐dihydroguanosine (8‐oxoGuo)...
Diabetic nephropathy (DN) represents the most prevalent and severe microvascular complication associated with diabetes. Along DN mechanism developing, inflammation were regarded as critical process in its development. Due to tripterygium glycosides (TWP) anti-inflammation effects, it was adapted symptoms releasing treatment. Considering TWP significant pharmacokinetic variability, solid effect marker required for further clinical applications.
Background: The current study investigated the clinical application of T-SPOT.TB assay for detecting tuberculosis (TB) infection in chronic kidney disease patients treated with immunosuppressive therapy. Methods: Clinical data from 91 were retrospectively analyzed. rate positive results and spot numbers compared before after treatment. characteristics that may affect test also investigated. Results: Two active TB cases observed treatment, eight negative at baseline had No significant changes...
Abstract Low-molecular-weight heparin (LMWH) is an anticoagulant used to prevent clotting during blood purification treatments. This study aimed evaluate the clinical use of anti-factor Xa level (anti-Xa) for monitoring LMWH levels intermittent venovenous hemofiltration (IVVHF). prospective observational enrolled patients who required IVVHF renal failure in Beijing Hospital between May 2019 and February 2021. The anticoagulation was assessed by coagulation grade filter line. One hundred ten...
2007 to 2016 in our tertiary hospital.Patients with Stage 4 and 5 CKD were excluded from the study.Multivariate analysis was performed using backwards stepwise logistic regression, variable entry exit criteria of p < 0.05 > 0.10 respectively.The area under receiver-operator characteristic curves (AUROC) evaluated assess model discrimination.RESULTS: The cohort included 64 males (62.7%), mean age 55.7 years (611.0)and duration T2DM 10.4 (67.2).The predominant ethnic group Chinese (79.4%).Mean...
Objective To explore the best operation and power option in ultrasonic dental cleaning without damaging teeth. Methods Twenty-five unorganized teeth were used this study,which divided into three groups of A,B D,and normal one was as control.Each group 8 cleaned with different technique,and then observed under scannig electron microscope.Meanwhile,200 cases patients,100 experimental other 100 control,were selected to clean by well-trained dentists.In half a year they followed up...
Abstract Background: Sclerotin is an antagonist of the Wnt-β-catenin pathway, may play important role in pathophysiology artery atherosclerosis. Previously, we reported that sclerostin was closely related to carotid atherosclerosis and long-term outcomes hemodialysis patients. Here, aimed investigate associations with renal function non-dialysis patients chronic kidney disease stages 3–5 (CKD 3–5ND). Methods: A total 140 CKD 3–5ND were enrolled this cross-sectional study. The Chronic Kidney...
Beijing Hospital, National Center of Gerontology; Institute Geriatric Medicine, Chineses Academy Medical Sciences, Beijing, China.