A5060009543- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Gastric Cancer Management and Outcomes
- Catalytic Processes in Materials Science
- Metabolomics and Mass Spectrometry Studies
- HER2/EGFR in Cancer Research
- Neuroendocrine Tumor Research Advances
- Multiple Myeloma Research and Treatments
- Electrocatalysts for Energy Conversion
- Ovarian cancer diagnosis and treatment
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Amino Acid Enzymes and Metabolism
- Angiogenesis and VEGF in Cancer
- Acute Myeloid Leukemia Research
- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
- Botanical Studies and Applications
- Advanced Polymer Synthesis and Characterization
- Phytochemical and Pharmacological Studies
- Optical Coherence Tomography Applications
- Molecular Junctions and Nanostructures
- Blood groups and transfusion
- X-ray Diffraction in Crystallography
- Colorectal Cancer Treatments and Studies
Peking University People's Hospital
2024
Peking University
2024
Wenzhou Medical University
2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Nanjing University of Chinese Medicine
2023
China Jiliang University
2023
Wuhan University
2023
South China University of Technology
2021-2023
Chinese PLA General Hospital
2023
Union Hospital
2014-2021
The present study investigated the value of combinations five specific tumor biomarkers for diagnosis colorectal cancer (CRC): Neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), (CA)19-9, CA125 and CA242. Associations between these markers clinicopathological characteristics (including Tumor-Node-Metastasis stage) were also assessed. Serum levels 5 compared 358 patients with CRC 298 healthy individuals (CRC control group, respectively). NSE concentration group was significantly...
A novel bromine-isotope probe named D-BPBr with stereodynamic chiral recognition characteristics was developed for the labeling, separation, and detection of trace amino acids amino-containing metabolites. Fourteen enantiomeric pairs could be successfully separated quantified on a reverse-phase C18 column an HPLC-MS/MS system after labeling. The chromatographic resolution d,l-amino acid enantiomers ranged from 1.14 to 8.83 l-amino derivative always eluting prior corresponding d-enantiomer....
ABSTRACT Quantifying ocular tissue mechanical properties is pivotal for elucidating eye disease etiology and progression. Optical coherence elastography (OCE), leveraging high‐resolution optical tomography, promises stiffness assessment. Traditional OCE relies on data processing of the time‐of‐flight method encounters challenges like low repeatability. Our study presents an optimized workflow integrating with deep learning to predict biomechanical properties. The concentration prediction...
Copper-catalyzed aerobic oxidative C–S bond coupling reaction between thiophenols and aryl-substituted alkenes for (E)-vinyl sulfones synthesis is reported here. With air utilized as a green oxidant, this transformation not only produces various vinyl in moderate to good yields but also possesses simple ecofriendly system. To clarify the mechanism, kinetic experiments has been investigated.
Sequence differences in the Src family kinase Fgr decrease its autoinhibitory regulation and increase sensitivity to a myeloproliferative cytokine.
Screening of characteristic biomarkers from chiral amino-containing metabolites in biological samples is difficult and important for the noninvasive diagnosis gastric cancer (GC). Here, an enantiomeric pair chlorine-labeled probes d-BPCl l-BPCl was synthesized to selectively label d- l-amino-containing samples, respectively. Incorrect structural annotations were excluded according 3:1 abundance ratio natural chlorine isotopes (35Cl 37Cl) derived probes. A sensitive C18 HPLC-QQQ-MS/MS method...
Unregulated protein-tyrosine kinase signaling is a common feature of AML, often involving mutations in Flt3 and overexpression myeloid Src-family kinases (Hck, Fgr, Lyn). Here we show that high-level expression these Src predicts poor survival large cohort AML patients. To test the therapeutic benefit inhibition, used pyrrolopyrimidine inhibitor A-419259. This compound potently inhibits Hck, Lyn as well bearing an activating internal tandem duplication (ITD). Flt3-ITD sensitized human TF-1...
The targeting protein for the Xenopus kinesin‑like 2 (TPX2), a microtubule-associated protein, has been utilized as tool to evaluate, more precisely, proliferative behavior of tumor cells. abnormal expression TPX2 in variety malignant types reported, however less is known about its role cervical cancer. In present study, association between and biological cancer, was investigated. Immunohistochemistry RT-PCR were used detect cancer tissues. inhibitory effect TPX2-siRNA on growth SiHa human...
Nanoscale polymeric micelles have attracted more and attention as a promising nanocarrier for controlled delivery of antineoplastic drugs. Herein, the doxorubicin (DOX)-loaded poly(D-lactide)-based micelle (PDM/DOX), poly(L-lactide)-based (PLM/DOX), stereocomplex (SCM/DOX) from equimolar mixture enantiomeric four-armed poly(ethylene glycol)-polylactide (PEG-PLA) copolymers were successfully fabricated. In phosphate-buffered saline (PBS) at pH 7.4, SCM/DOX exhibited smallest hydrodynamic...
This communication reports copper-catalyzed N-H olefination of sulfonamides for enaminone synthesis using saturated ketones as olefin sources. With TEMPO derivatives and O2 oxidants, this method provided an efficient way to produce various enaminones in good yields. Mechanistic studies helped figure out the stable intermediates develop novel methodologies difunctionalization ketones.
In this work, we report a new design strategy to synthesize double-cable polymer acceptor PT-BTP composed of fused-ring Y-series framework as pendant side unit and thiophene derivative the conjugated backbone.
Abstract This study investigated the diagnostic value of preoperative serum neuro-specific enolase (NSE) in gastric cancer (GC) and colorectal (CRC), viability combined NSE, carcinoembryonic antigen (CEA), (CA)19-9, CA242. Patients with GC CRC, a healthy control group (n = 666 266, respectively) were compared regard to CEA, CA19-9, CA242 levels. NSE was analyzed for associations clinicopathological parameters. To estimate potential receiver operating characteristic curve constructed area...
Organic pollutants pose a serious threat to human health, and so their control by photocatalytic techniques has become an important field. There is urgent need devise convenient syntheses of effective photocatalysts for the degradation contaminants. Here, high-performance anatase TiO 2 nanowires have been obtained through hydrothermal method followed calcination at different temperatures in Ar. The products characterized SEM, XRD, FTIR, UV/Vis DRS measurements. performances as-prepared...
Abstract Mitochondrial diseases are a group of heterogeneous genetic metabolic caused by mitochondrial DNA (mtDNA) or nuclear (nDNA) gene mutations. Mining the gene-disease association is helpful for understanding pathogenesis diseases, carrying out early clinical diagnosis related and formulating better treatment strategies diseases. This project researched relationship between genes combined Malacards, Genecards, MITOMAP disease databases to mine knowledge on genes, used database...
Abstract Quantifying the mechanical properties of cornea can provide valuable insights into occurrence and progression keratoconus, as well effectiveness corneal crosslinking surgery. This study presents a non‐contact non‐invasive wave‐based optical coherence elastography system that utilizes air‐pulse stimulation to create two‐dimensional map elasticity. Homogeneous dual concentration phantoms were measured with sampling 25 × points over 6.6 mm 2 area, verify measurement capability for...
Abstract As a biomarker, neuron-specific enolase (NSE) has been widely recognized in the diagnosis of benign diseases and malignant tumors. This study aimed to investigate potential diagnostic value NSE patients with gastric adenocarcinoma. Serum levels were compared between 219 adenocarcinoma 298 healthy individuals, clinicopathological parameters analyzed. Meanwhile, evaluate capability NSE, receiver operating characteristic (ROC), area under curve (AUC) was calculated. In present study,...