A5100737082- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Immune cells in cancer
- Retinal Diseases and Treatments
- Optical Coherence Tomography Applications
- Glaucoma and retinal disorders
- Histone Deacetylase Inhibitors Research
- Renal Diseases and Glomerulopathies
- Glioma Diagnosis and Treatment
- Spaceflight effects on biology
- MicroRNA in disease regulation
- Systemic Lupus Erythematosus Research
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Systemic Sclerosis and Related Diseases
- Nanoplatforms for cancer theranostics
- Ophthalmology and Visual Impairment Studies
- Macrophage Migration Inhibitory Factor
- Viral gastroenteritis research and epidemiology
- Photoacoustic and Ultrasonic Imaging
- Cancer-related gene regulation
- Corneal Surgery and Treatments
- HVDC Systems and Fault Protection
- S100 Proteins and Annexins
- Chemokine receptors and signaling
Zhejiang Gongshang University
2025
Jimei University
2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Wenzhou Medical University
2021-2024
Dongguan People’s Hospital
2024
Third Affiliated Hospital of Southern Medical University
2023
Shenyang Aerospace University
2022
Southern Medical University
2021-2022
Nanfang Hospital
2021-2022
Zhongshan Hospital of Xiamen University
2021
The macrophage, one of the several key immune cell types, is believed to be involved in tumorigenesis. However, mechanism macrophages promoting tumor progression largely unknown. differentially secreted proteins M1 and M2 were analyzed by mass spectrometry. We performed GST pull-down assay for identification cell-membrane receptors that interact with chitinase 3-like protein 1 (CHI3L1) protein. mouse model was used validate function CHI3L1 cancer metastasis vivo. Protein phosphorylation gene...
Dextran modified with pendant acetals is used to load doxorubicin (DOX) and a near-infrared-emissive conjugated polymer (BTTPF), this aims provide selective drug release at therapeutic targets including tumors. The BTTPF applicable tracking the anticancer through change of Förster resonance energy transfer efficiency between during degradation nanoparticles in vivo.
Glioma is the most common malignancy of nervous system with high mortality rates. The MS4A family members have been reported as potential prognostic biomarkers in several cancers; however, relationship between and glioma has not clearly confirmed. In our study, we explored value MS4As well their pro-cancer mechanisms glioma. Using bioinformatics analysis methods based on data from public databases, found that expression MS4A4A, MS4A4E, MS4A6A, MS4A7, TMEM176A, TMEM176B was significantly...
Purpose To investigate the contrast sensitivity function (CSF) changes in simple high myopia (SHM) and evaluate correlations between these with early retinal microstructure. Methods This prospective study comprised 81 subjects, 20 emmetropia (EM), 26 low moderate (LM/MM), 35 SHM. The area under log CSF curve (AULCSF) cut-off spatial frequency (Cut-off SF) were employed as measures of CSF. Adaptive optics (AO) was to quantify cone density, spacing, regularity. thickness blood flow sublayers...
Abstract Aims Growth differentiation factor 15 (GDF15) is involved in lots of crucial inflammatory and immune response. The clinical features for GDF15 glioma have not been specifically investigated so far. Methods Gene expression profiles obtained from public datasets were used to explore the biological function its impact on microenvironment. Interference with several cell lines verify functions vitro. Survival data survival analysis establishment a nomogram predictive model. Results was...
Lens biomechanics has great potential for application in clinical diagnostics and treatment monitoring of presbyopia cataracts. However, current approaches to lens elastography do not meet the desired safety or sensitivity application. In this regard, we propose a noncontact optical coherence (OCE) method facilitate quantitative situ imaging elasticity. Elastic waves induced by air-pulse stimulation on limbus propagate are then imaged using custom-built swept-source tomography obtain elastic...
Quantifying the mechanical properties of iris can offer valuable insights into pathophysiology primary angle closure glaucoma. However, current techniques for elastography remain ex vivo with limited clinical applications. This article describes a proposition non-contact and non-invasive air-puff optical coherence (OCE) system that evaluate elasticity in vivo. Ten eyes recruited from seven subjects underwent OCE imaging acquisition under three different illumination conditions. The Young's...
Purpose To assess the safe, lowest effective laser power of subthreshold micropulse (SML) for treating acute and chronic central serous chorioretinopathy (CSC) in Chinese patients. Methods Patients were distinguished with or CSC based on focal diffuse retinal pigment epithelium (RPE) leakage fundus fluorescein angiography (FFA), without widespread RPE decompensation. categorized into five groups treated 577 nm yellow SML according to 50% titration power. The change best-corrected visual...
Virus infection can change host's metabolism, while tumorigenesis results from metabolic disorder. MicroRNAs (miRNAs), crucial regulatory factors overlaying transcriptional control mechanisms, guide homeostasis. In terms of disorder, antiviral miRNAs may have anti-tumor activity. However, this issue has not been extensively investigated. the present study, revealed that shrimp mja-miR-35, which showed activity in against white spot syndrome virus (WSSV) infection, could suppress metastasis...
During viral infection in vertebrates, cytokines play important roles the host defense against virus. However, function of invertebrates has not been well characterized. In this study, shrimp involved were screened using a cytokine antibody microarray. The results showed that three cytokines, Fas receptor (Fas), platelet factor 4 (PF4) and interleukin-22 (IL-22), significantly upregulated white spot syndrome virus (WSSV)-challenged shrimp, suggesting these played positive regulatory immune...
It has been reported that the most common post-transcriptional modification of eukaryotic RNA is N6-methyladenosine (m6A). Previous studies show m6A a key regulator for viral infection and immune response. However, whether there pathogen stimulus-dependent regulation in invertebrate shrimp not studied. In this study, we performed transcriptome-wide profiling mRNA methylation (Marsupenaeus japonicus) after white spot syndrome virus (WSSV) by methylated immunoprecipitation sequencing...
Abstract Quantifying the mechanical properties of cornea can provide valuable insights into occurrence and progression keratoconus, as well effectiveness corneal crosslinking surgery. This study presents a non‐contact non‐invasive wave‐based optical coherence elastography system that utilizes air‐pulse stimulation to create two‐dimensional map elasticity. Homogeneous dual concentration phantoms were measured with sampling 25 × points over 6.6 mm 2 area, verify measurement capability for...
To characterize the regional variations of choroidal vascularity index (CVI) in patients with diabetes mellitus (DM) using ultra-wide-field optical coherence tomography angiography (UWF-OCTA) and identify their correlations onset diabetic retinopathy (DR).
Indentation gonioscopy is commonly used in the clinic to evaluate peripheral anterior synechia (PAS) of angle closure glaucoma (ACG). The examination requires contacting with cornea, resulting an uncomfortable feeling for patients, and it only provides qualitative outcomes which may be affected by subjective judgment clinicians. Previous studies had reported identify presence PAS measuring changes morphological parameters chamber (ACA) under pupillary light reflex, segment optical coherence...
为研究航天相关神经眼综合征（SANS）相关特征参数与微重力的相关性，以Sprague-Dawley（SD）大鼠为悬尾动物模型，构建了超长扫描深度的光学相干断层扫描（ULOCT）装置，测量大鼠眼部特征参数（角膜、前房、晶状体厚度和玻璃体腔深度及眼轴长度），以及视网膜超高分辨率（UHROCT）测量装置，测量大鼠眼底亚层结构参数（视神经层、视网膜内层、视网膜外层、脉络膜和巩膜的厚度）。结果表明大鼠悬尾1月后，眼底彩照未见明显视盘水肿等症状，但OCT结果显示大鼠眼结构发生明显改变：角膜变薄（<i>p</i><0.01），眼轴缩短（<i>p</i><0.05），视网膜外层变薄（<i>p</i><0.01）。这些特征参数变化（尤其是眼轴明显缩短）展现了SANS亚临床前期的症状。本文为后续微观层面的SANS分子机制研究提供了宏观的动物模型以及体眼部测量新方法。
Chen, Yulei; Zhang, Xiao; Luo, Yuxin; Junzhe; Tang, Ying; Nephrology Dept. Author Information
In view of the high dimensionality data in many fields and serious multiple correlation between variables, this paper proposes an interpretable partial least square regression (PLSR) modeling method. Compared with principal component (PCR), when there are a large number predictors, both PLSR PCR model response predictors highly correlated or even collinear. Both these methods construct new (called components) as linear combinations original but they components different ways. We use series...