A5031052028- Glioma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Academic Publishing and Open Access
- Neurogenesis and neuroplasticity mechanisms
- Computational and Text Analysis Methods
- Artificial Intelligence in Healthcare and Education
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- Reproductive Biology and Fertility
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Health and Medical Education
- Cancer Genomics and Diagnostics
- scientometrics and bibliometrics research
- Epigenetics and DNA Methylation
- Brain Metastases and Treatment
- Plant Genetic and Mutation Studies
- Metabolism, Diabetes, and Cancer
- Data-Driven Disease Surveillance
- Misinformation and Its Impacts
Biogipuzkoa Health Research Institute
2015-2022
Background: SOX2 and SOX9 are commonly overexpressed in glioblastoma, regulate the activity of glioma stem cells (GSCs). Their specific overlapping roles GSCs treatment remain unclear.Methods: levels were examined human biopsies. Gain loss function determined impact altering on cell proliferation, senescence, activity, tumorigenesis chemoresistance.Results: expression correlates positively glioblastoma High bypass cellular senescence promote resistance to temozolomide. Mechanistic...
The impairment of the activity brain is a major feature aging, which coincides with decrease in function neural stem cells. We have previously shown that an extra copy regulated Ink4/Arf and p53 activity, s-Ink4/Arf/p53 mice, elongates lifespan delays aging. In this work, we examined physiology focusing on cell (NSC) population. show cells derived from old mice display enhanced neurosphere formation self-renewal compared wt controls. This correlates augmented expression Sox2, Sox9, Glast,...
<ns5:p><ns5:bold>Background:</ns5:bold> The COVID-19 outbreak has made funders, researchers and publishers agree to have research publications, as well other outputs, such data, become openly available. In this extraordinary context of the SARS CoV-2 pandemic, are announcing that their coronavirus-related articles will be immediately accessible in appropriate open repositories, like PubMed Central, agreeing upon funders’ researchers’ instigation.</ns5:p><ns5:p> <ns5:bold>Methods:</ns5:bold>...
The elucidation of mechanisms involved in resistance to therapies is essential improve the survival patients with malignant gliomas. A major feature possessed by glioma cells that may aid their ability survive therapy and reconstitute tumors capacity for self-renewal. We show here stem (GSCs) express low levels MKP1, a dual-specificity phosphatase, which acts as negative inhibitor JNK, ERK1/2, p38 MAPK, while induction high MKP1 expression are associated differentiation GSC. Notably, we find...
Abstract Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal during aging remain largely unknown. In this work, we show that p38MAPK increases in neurons with age. By using mice expressing p38α‐lox CamkII‐Cre alleles ( p38α∆‐N ), demonstrate genetic deletion of p38α suffices to reduce age‐associated elevation activity, loss cognitive decline. Moreover, aged present elevated numbers NSCs the hippocampus subventricular zone. These...
<ns4:p><ns4:bold>Background:</ns4:bold> The COVID-19 outbreak has made funders, researchers and publishers agree to have research publications, as well other outputs, such data, become openly available. In this extraordinary context of the SARS CoV-2 pandemic, are announcing that their coronavirus-related articles will be immediately accessible in appropriate open repositories, like PubMed Central (PMC), agreeing upon funders’ researchers’ instigation.</ns4:p><ns4:p>...
Age-progressive neural stem cell (NSC) dysfunction leads to impaired neurogenesis, cognitive decline and the onset of age-related neurodegenerative pathologies.p38MAPK signalling pathway limits activity during aging in several tissues.Its role NSCs remains controversial.In this work, we show that p38MAPK increases with age subventricular zone (SVZ) its pharmacological inhibition is sufficient rejuvenate their vitro.These data reveal a cell-autonomous for increase decreasing NSC homeostasis...
Embryonic Stem (ES) cells have the ability to self-renew as well differentiate into of three germ layers (ectoderm, endoderm and mesoderm) due their pluripotency, giving rise a variety differentiated cells, such cardiomyocytes [1]. They constitute an excellent model system study effects ionizing radiation on early embryonic development that are still poorly understood [2]. The used for present work is mouse ES-D3 cell line, both pluripotency maintenance develop was assessed. were exposed...
In humans the effect of ionizing radiation on early embryonic development is not yet understood in detail. vivo studies mice have shown that lethality most frequent outcome after exposure pre-implantation stage [1].To estimate risk an utero exposure, e.g. case accidental or a medical treatment expectant mother [2] we chose H9 human stem cells (ESCs) as model system. Differentiating ESCs vitro resembles developmental stages embryo vivo.
1575 Background: Conflicting epidemiologic studies have suggested insulin and their analogues currently used in the management of type 2 diabetes to be involved tumor progression development. Surprisingly, time exposure analogs reported those retrospective is too short for a carcinogen. We hypothesized that differential affinity display receptor IGF-1R at CICs may account this possibility. [AspB10]insulin (X10) long-acting analog displays greater IGF1R than either GLA or human (HI) vitro....
The International Journal of Integrated Care (IJIC) is an online, open-access, peer-reviewed scientific journal that publishes original articles in the field integrated care on a continuous basis.IJIC has Impact Factor 5.120 (2020 JCR, received June 2021)
<sec> <title>BACKGROUND</title> The COVID-19 outbreak showed the importance of rapid access to research. </sec> <title>OBJECTIVE</title> This paper investigates research communication about this disease, level openness papers, and main topics into disease. <title>METHODS</title> Thus, it analyses Open Access (OA) uptake (typologies, licence use) topic evolution publications, from start pandemic (1 January 2020) until end a year widespread lockdown March 2021). <title>RESULTS</title> sample...