A5018595853- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Cancer Cells and Metastasis
- Single-cell and spatial transcriptomics
- Traumatic Brain Injury and Neurovascular Disturbances
- Congenital heart defects research
- Trace Elements in Health
- Intracranial Aneurysms: Treatment and Complications
- Alcoholism and Thiamine Deficiency
- Circular RNAs in diseases
- Corneal Surgery and Treatments
- Glioma Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Hemoglobin structure and function
- Renal and related cancers
- Hip and Femur Fractures
- Ocular Diseases and Behçet’s Syndrome
- Retinal Diseases and Treatments
- Erythrocyte Function and Pathophysiology
- RNA regulation and disease
- Genetics and Neurodevelopmental Disorders
- Tumors and Oncological Cases
- Endoplasmic Reticulum Stress and Disease
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2024
Biogipuzkoa Health Research Institute
2019-2024
Instituto de Salud Carlos III
2022-2023
Osakidetza
2021-2022
Centro de Investigación Biomédica en Red
2022
Hospital Universitario Virgen del Rocío
2012-2013
Abstract The developmental regulator SOX9 is linked to cancer progression mainly as a result of its role in the regulation stem cells (CSCs). However, activity differentiated that constitute heterogeneous tumor bulk has not been extensively studied. In this work, we addressed aspect gastric cancer, glioblastoma and pancreatic adenocarcinoma. silencing studies revealed required for cell survival, proliferation evasion senescence vitro growth vivo . Gain of- function showed high levels promote...
Abstract The hippocampus is a brain area linked to cognition. mechanisms that maintain cognitive activity in humans are poorly understood. Centenarians display extreme longevity which generally accompanied by better quality of life, lower impairment, and reduced incidence pathologies including neurodegenerative diseases. We performed transcriptomic studies samples from individuals different ages (centenarians [≥97 years], old, young) identified differential gene expression pattern...
Adult lungs present high cellular plasticity against stress and injury, mobilizing stem/progenitor populations from conducting airways to maintain tissue homeostasis gas exchange in alveolar spaces. With aging, pulmonary functional structural deterioration occurs, mainly pathological conditions, which is associated with impaired stem cell activity increased senescence mice. However, the impact of these processes underlying lung physiopathology relation aging has not been explored humans. In...
Abstract Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal during aging remain largely unknown. In this work, we show that p38MAPK increases in neurons with age. By using mice expressing p38α‐lox CamkII‐Cre alleles ( p38α∆‐N ), demonstrate genetic deletion of p38α suffices to reduce age‐associated elevation activity, loss cognitive decline. Moreover, aged present elevated numbers NSCs the hippocampus subventricular zone. These...
Abstract Age‐related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged subventricular zone (SVZ) suffers an infiltration of T cells, which affects neural stem cell activity in mice. Whether this occurs human niches or to extent T‐cell is also taking place remains unknown. In work, we studied the presence cells both young old individuals. There was a significant increase number CD3 + CD8 SVZ elderly...
Abstract Cellular plasticity plays critical roles in tissue regeneration, tumour progression and therapeutic resistance. However, the mechanism underlying this cell state transition remains elusive. Here, we show that transcription factor SOX2 induces fetal reprogramming reversible dormancy colorectal cancer (CRC). expression correlates with poor prognosis human primary metastatic adenocarcinomas. In mouse CRC models, rare slow-cycling + SCA1 cells are detected early Apc -deleted tumours...
Glioma stem cells (GSCs) are critical targets for glioma therapy. SOX9 is a transcription factor with roles during neurodevelopment, particularly within neural cells. Previous studies showed that high levels of associated poor patient survival. knockdown impairs GSCs proliferation, confirming its potential as target In this study, we characterized the function directly in patient-derived Notably, transcriptome analysis revealed STAT3 and PML downstream targets. Functional demonstrated SOX9,...
Tribbles pseudokinase 3 (TRIB3) has been proposed to both promote and restrict cancer generation progression. However, the precise mechanisms that determine this dual role of TRIB3 in remain be understood. In study we aimed investigate luminal breast cancer, most frequent subtype malignancy.We genetically manipulated expression a panel cell lines analyzed its impact on proliferation, phosphorylation, levels, or subcellular localization other protein regulators key signaling pathways cancer....
The presence and functional role of T cell infiltration in human brain parenchyma with normal aging neurodegeneration is still under intense debate. Recently, CD8+ cells have been shown to infiltrate the subventricular zone humans mice a deleterious effect on neural stem cells. However, which extent also occurs other regions such as cortical areas and, especially, white matter (WM) has not yet addressed. In this work, we report low-grade (CD3+, CD4+ CD8+) WM aged individuals that observed at...
Abstract Background Gastric Cancer (GC) presents poor outcome, which is consequence of the high incidence recurrence and metastasis at early stages. GC patients presenting recurrent or metastatic disease display a median life expectancy only 8 months. The mechanisms underlying progression remain poorly understood. Methods We took advantage public available datasets from TCGA using GEPIA, identified matched genes among 100 most significantly associated with overall survival (OS) free (DFS)....
We present a case report on an older woman with unspecific symptoms and predominant long-term gastrointestinal disturbances, acute overall health deterioration loss of autonomy for daily activities, cognitive impairment. Autopsy revealed the presence alpha-synuclein deposits spread into intestinal mucosa lesions, enteric plexuses, pelvic retroperitoneal nerves ganglia, other organs as well Lewy pathology in central nervous system (CNS). Moreover, we isolated norovirus from patient,...
Fibrosis in the posterior segment of eye tends to be final stage resolution lesions retina and choroid. Two diseases that most often cause this type fibrosis are diabetes age-related macular degeneration (AMD).1 The main aetiopathogenetic mechanisms involved development hypoxia inflammation. In case AMD, retinal pigment epithelium dysfunction leads accumulations substances (drusen) with angiogenic activity on Bruch's membrane, becoming thicker limiting oxygen diffusion external layers...