A5076048754- Cleft Lip and Palate Research
- Oral microbiology and periodontitis research
- Laser Applications in Dentistry and Medicine
- Hedgehog Signaling Pathway Studies
- Temporomandibular Joint Disorders
- dental development and anomalies
- Orthodontics and Dentofacial Orthopedics
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Prenatal Screening and Diagnostics
- Genomics and Phylogenetic Studies
- Photopolymerization techniques and applications
- Probiotics and Fermented Foods
- Craniofacial Disorders and Treatments
Peking University
2007-2018
King University
2018
Abstract The isolated type of orofacial cleft, termed non-syndromic cleft lip with or without palate (NSCL/P), is the second most common birth defect in China, Asians having highest incidence world. NSCL/P involves multiple genes and complex interactions between genetic environmental factors, imposing difficulty for assessment unborn fetus carrying NSCL/P-susceptible variants. Although genome-wide association studies (GWAS) have uncovered dozens single nucleotide polymorphism (SNP) loci...
Cleft lip and/or palate (CL/P) is the most common craniofacial congenital disease, and it has a complex aetiology. This study aimed to identify causative gene mutation of Han Chinese family with CL/P.Whole exome sequencing was conducted on proband her mother, who exhibited same phenotype. A Mendelian dominant inheritance model, allele frequency, regions, functional prediction literature review were used screen filter variants. The candidate validated by Sanger sequencing. Conservation...
Abstract Several studies have documented the diversity and potential pathogenic associations of organisms in human oral cavity. Although much progress has been made understanding complex bacterial community inhabiting cavity, our some microorganisms is less resolved due to a variety reasons. One such little-understood group candidate phyla radiation (CPR), which recently identified, but highly abundant ultrasmall bacteria with reduced genomes unusual ribosomes. Here, we present computational...