A5041687327- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Genetic Associations and Epidemiology
- Advanced Neuroimaging Techniques and Applications
- Bioinformatics and Genomic Networks
- Cognitive Abilities and Testing
- COVID-19 and healthcare impacts
- Long-Term Effects of COVID-19
- Online Learning and Analytics
- Down syndrome and intellectual disability research
- Intelligent Tutoring Systems and Adaptive Learning
- Folate and B Vitamins Research
- Cancer, Lipids, and Metabolism
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Health, Environment, Cognitive Aging
- Radiology practices and education
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related cognitive impairment studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Epigenetics and DNA Methylation
Vanderbilt University Medical Center
2013-2024
Vanderbilt University
2012-2017
Center for Human Genetics
2012-2014
Duke Medical Center
2012
While immune function is known to play a mechanistic role in Alzheimer's disease (AD), whether proteins peripheral circulation influence the rate of amyloid-β (Aβ) progression – central feature AD remains unknown. In Baltimore Longitudinal Study Aging, we quantified 942 immunological plasma and identified 32 (including CAT [catalase], CD36 [CD36 antigen], KRT19 [keratin 19]) associated with rates cortical Aβ accumulation measured positron emission tomography (PET). changes subset candidate...
Recent advancements in AI models are structured to retain user interactions, which could inadvertently include sensitive healthcare data. In the field, particularly when radiologists use AI-driven diagnostic tools hosted on online platforms, there is a risk that medical imaging data may be repurposed for future training without explicit consent, spotlighting critical privacy and intellectual property concerns around usage. Addressing these challenges, novel approach known as Unlearnable...
Summary Variations in the KCNJ6 gene appear to influence both acute and chronic pain phenotypes. G-protein coupled inwardly rectifying potassium (GIRK) channels are effectors determining degree of analgesia experienced upon opioid receptor activation by endogenous exogenous opioids. The impact GIRK-related genetic variation on human responses has received little research attention. We used a tag single nucleotide polymorphism (SNP) approach comprehensively examine pain-related effects KCNJ3...
Individuals with Down Syndrome (DS) are reported to experience early onset of brain aging. However, it is not well understood how pre-existing neurodevelopmental effects versus neurodegenerative processes might be contributing the observed pattern atrophy in younger adults DS. The aims current study were to: (1) confirm previous findings age-related changes DS compared typical development (TD), (2) test for an effect these a second disorder, Williams syndrome (WS), and (3) identify regional...
BackgroundNovel risk variants for late-onset Alzheimer's disease (AD) have been identified and replicated in genome-wide association studies. Recent work has begun to address the relationship between these biomarkers of AD, though results mixed. The aim current study was characterize single marker epistatic genetic effects top candidate Single Nucleotide Polymorphisms (SNPs) relation amyloid deposition. MethodsWe used a combined dataset across ADNI-1 ADNI-2, looked within each separately...
BackgroundProspectively predicting response to intra-arterial therapy for hepatocellular carcinoma (HCC) is challenging. Neutrophil/lymphocyte ratio (NLR) a serum biomarker that associated with survival multiple malignancies. It was hypothesized increased NLR would be early disease progression after of HCC.MethodsThe outcomes 86 treatment-naïve patients who had chemoembolization or radioembolization HCC between July 2013–July 2014 were reviewed. Pre-treatment laboratory tests and imaging...
Abstract Background Genomic imprinting is an epigenetic phenomenon resulting in parent-of-origin specific monoallelic gene expression. It postulated to have evolved placental mammals modulate intrauterine resource allocation the offspring. In this study, we determined imprint status of metatherian orthologues eutherian imprinted genes. Results L3MBTL and HTR2A were shown be Monodelphis domestica (the gray short-tailed opossum). MEST expressed a biallelic transcript, as eutherians. contrast,...
The genetic etiology of late-onset Alzheimer's disease (LOAD) has proven complex, involving clinical and heterogeneity gene-gene interactions. Recent genome wide association studies in LOAD have led to the discovery novel risk
A subset of individuals present at autopsy with the pathologic features Alzheimer's disease having never manifest clinical symptoms. We sought to identify genetic factors that modify relationship between phosphorylated tau (PTau) and dilation lateral inferior ventricles.
Background: While a great deal of work has gone into understanding the relationship between CSF biomarkers, brain atrophy, and disease progression, less attempted to investigate how genetic variation modifies these relationships. The goal this study was two-fold. First, we sought identify high-risk v. low-risk individuals based on their tau Aβ load characterize with regard atrophy in an AD-relevant region interest. Next, variants that modified biomarker classification neurodegeneration....
Imaging genetics is an emerging methodological field that combines genetic information with medical imaging-derived metrics to understand how factors impact observable phenotypes. In order for a trait be reasonable phenotype in imaging study, it must heritable: at least some proportion of its variance due influences. The Sequential Oligogenic Linkage Analysis Routines (SOLAR) software can estimate the heritability complex pedigrees. We investigate ability SOLAR accurately and common...
Resin Yttrium-90 (Y90) microspheres have historically been infused using sterile water (H2O). In 2013, recommendations expanded to allow delivery with 5% dextrose in (D5W). this retrospective study, we hypothesized that D5W would improve Y90 a lower incidence of stasis. We reviewed 190 resin infusions H2O (n=137) or (n=53). dosimetry was calculated the body surface area method. Infusion halted if intra-arterial stasis fluoroscopically identified prior clearing vial. Differences between and...
Imaging genetics is an emerging methodology that combines genetic information with imaging-derived metrics to understand how factors impact observable structural, functional, and quantitative phenotypes. Many of the most well-known studies are based on Genome-Wide Association Studies (GWAS), which use large populations related or unrelated individuals associate traits disorders individual factors. Merging imaging may potentially lead improved power association in GWAS because be more...
Abstract Background Individuals diagnosed with COVID‐19 have been found to changes in brain structure as well dramatic neuropsychiatric effects such dementia, Parkinsonism, and greater likelihood of stroke (Taquet, 2021). Infection has also shown result hypometabolic on 18F ‐fluorodeoxyglucose positron emission tomography (FDG PET) when compared normal controls (Guedj, This study will seek determine which regions are most affected by FDG PET. To our knowledge, we the first compare pre‐...
Abstract Background Individuals diagnosed with COVID‐19 have been found to changes in brain structure as well dramatic neuropsychiatric effects such dementia, Parkinsonism, and greater likelihood of stroke (Taquet, 2021). Infection has also shown result hypometabolic on 18 F ‐fluorodeoxyglucose positron emission tomography (FDG PET) when compared normal controls (Guedj, This study will seek determine which regions are most affected by FDG PET. To our knowledge, we the first compare pre‐...
Abstract Background and Purpose Adverse neurological effects after cancer therapy are common, but biomarkers to diagnose, monitor, or risk stratify patients still not validated used clinically. An accessible imaging method, such as fluorodeoxyglucose positron emission tomography (FDG PET) of the brain, could meet this gap serve a biomarker for functional brain changes. We utilized FDG PET evaluate which regions most susceptible altered glucose metabolism chemoradiation in with head neck...
Individuals with Down syndrome (DS; trisomy 21) are at increased risk for Alzheimer's disease (AD) and they develop amyloid beta plaques (Aβ) by 30 years because have 3 copies of the gene encoding precursor protein (APP). Therefore, an ideal population in which to validate Aβ biomarkers. Currently, brain levels measured invasively via lumbar puncture or radioactive ligand-based positron emission tomography. Non-invasive biomarkers necessary early screening repeatability. T1-rho-weighted...