A5089504998- Bone health and treatments
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Microtubule and mitosis dynamics
- Pancreatic function and diabetes
- Thyroid Cancer Diagnosis and Treatment
- Nonmelanoma Skin Cancer Studies
- Palliative Care and End-of-Life Issues
- Pituitary Gland Disorders and Treatments
- Cancer Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Thyroid and Parathyroid Surgery
- Epigenetics and DNA Methylation
- Disaster Response and Management
- Bone Metabolism and Diseases
- Skin Protection and Aging
- Cutaneous Melanoma Detection and Management
- BRCA gene mutations in cancer
- Cellular transport and secretion
- Cardiac Arrest and Resuscitation
- Cardiac tumors and thrombi
- S100 Proteins and Annexins
- Genetic Syndromes and Imprinting
- Economic and Financial Impacts of Cancer
- Bone and Joint Diseases
Vanderbilt University
2014-2024
Vanderbilt University Medical Center
2010-2024
Memorial Healthcare System
2018-2023
Marymount University
2023
Health Net
2023
Memorial Regional Hospital
2022
Florida Atlantic University
2022
University Hospitals Plymouth NHS Trust
2013-2018
Plymouth Hospital
2013-2018
Duke University
2016
Individuals with Down Syndrome (DS) are reported to experience early onset of brain aging. However, it is not well understood how pre-existing neurodevelopmental effects versus neurodegenerative processes might be contributing the observed pattern atrophy in younger adults DS. The aims current study were to: (1) confirm previous findings age-related changes DS compared typical development (TD), (2) test for an effect these a second disorder, Williams syndrome (WS), and (3) identify regional...
Breast cancer cells frequently disseminate to the bone marrow, where they either induce osteolysis or enter a dormant state. Downregulation of leukemia inhibitory factor receptor (LIFR), known breast tumor suppressor, enables otherwise MCF7 human become aggressively osteolytic. Hypoxia (low oxygen tensions), which may develop in tumors as pathological response metabolic demands proliferating and physiological state bone, downregulates LIFR independent hypoxia-inducible (HIF) signaling....
Paragangliomas are rare neuroendocrine tumors that primarily arise in the adrenal gland. Head and neck paragangliomas comprise approximately 3% of all extra-adrenal paragangliomas, with a majority those being found carotid body. Recurrent laryngeal nerve exceedingly rare, only 2 reported cases literature review. Here, we will present third.
In pancreatic islet beta cells, molecular motors use cytoskeletal polymers microtubules as tracks for intracellular transport of insulin secretory granules. Beta-cell microtubule network has a complex architecture and is non-directional, which provide granules at the cell periphery rapid secretion response, yet to avoid over-secretion subsequent hypoglycemia. We have previously characterized peripheral sub-membrane array, critical withdrawal excessive from sites. Microtubules in cells...
Abstract The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports PTHrP inhibiting or promoting primary tumor growth preclinical studies. Here, we provide insight into these conflicting findings by assessing the specific biological domains progression through stable expression (-36-139aa) truncated forms deletion nuclear localization sequence (NLS) alone combination C-terminus. Although full-length molecule did not alter...
Abstract Inflammatory breast cancer (IBC) is a highly invasive and aggressive with relatively low survival rates compared other locally advanced cancers. IBC characterized by its rapid development of resistance to radio- chemotherapies, which may in part be due altered translational control driven overexpression the translation initiation factor, eIF4G1. This protein has been shown enhance eukaryotic mRNAs internal ribosome entry sites (IRES) enhanced play role tumor cells during cellular...
Abstract Inflammatory breast cancer (IBC) is the most lethal, distinct form of cancer, however, basis for its aggressiveness and rapid acquisition drug resistance not fully understood. Using immunohistochemical analysis, we identified a strong correlation between high grade, stage, triple-negative status elevated expression X-linked inhibitor apoptosis protein (XIAP) in IBC. Molecular profiling multiple IBC cell lines revealed that modulating XIAP can significantly alter pattern 79-gene,...
Abstract In pancreatic islet beta cells, molecular motors use cytoskeletal polymers microtubules as tracks for intracellular transport of insulin secretory granules. Beta-cell microtubule network has a complex architecture and is non-directional, which provide granules at the cell periphery rapid secretion response, yet to avoid over-secretion subsequent hypoglycemia. We have previously characterized peripheral sub-membrane array, critical withdrawal excessive from sites. Microtubules in...
In pancreatic islet beta cells, molecular motors use cytoskeletal polymers microtubules as tracks for intracellular transport of insulin secretory granules. Beta-cell microtubule network has a complex architecture and is non-directional, which provide granules at the cell periphery rapid secretion response, yet to avoid over-secretion subsequent hypoglycemia. We have previously characterized peripheral sub-membrane array, critical withdrawal excessive from sites. Microtubules in cells...