A5091308228- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Adenosine and Purinergic Signaling
- Cardiomyopathy and Myosin Studies
- Advanced Proteomics Techniques and Applications
- Macrophage Migration Inhibitory Factor
- Extracellular vesicles in disease
- Click Chemistry and Applications
- Enzyme Production and Characterization
- RNA Research and Splicing
- Insect symbiosis and bacterial influences
- Insect Resistance and Genetics
- Viral Infections and Immunology Research
- Food Allergy and Anaphylaxis Research
- Peptidase Inhibition and Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Pineapple and bromelain studies
- Signaling Pathways in Disease
The University of Texas at El Paso
2024-2025
Fundação Oswaldo Cruz
2020-2023
Universidade Federal de Juiz de Fora
2015-2021
Aberystwyth University
2020
Institute of Biological, Environmental and Rural Sciences
2020
Chagas disease, caused by Trypanosoma cruzi, remains a significant global health challenge, particularly in the molecular diagnostics of low parasitemia during chronic phase. This highlights critical need for enhanced diagnostic methodologies. In response, this study evaluates effectiveness an automated magnetic beads-based DNA extraction method improving diagnosis disease compared to traditional silica column-based extraction. Accordingly, research seeks enhance yield, purity, and...
Abstract In the heart tissue of acutely Trypanosoma cruzi -infected mice miR-145-5p and miR-146b-5p are, respectively, downregulated upregulated. Here, we used H9C2 rat cardiomyoblast cell line infected with Colombian T. strain to investigate parasite-host interplay, focusing on regulation expression. Next, explored effects interventions trypanosomicidal drug Benznidazole (Bz) alone or combined Pentoxifylline (PTX), a methylxanthine derivative shown modulate immunological cardiac...
Chronic Chagas cardiomyopathy (CCC) is one of the leading causes morbidity and mortality due to cardiovascular disorders in endemic areas disease (CD), a neglected tropical illness caused by protozoan parasite Trypanosoma cruzi . CCC characterized persistence inflammatory response heart tissue, which occur parallel microRNA (miRNA) alterations. Here, we investigated miRNA transcriptome profiling cardiac tissue chronically T -infected mice treated with suboptimal dose benznidazole (Bz),...
Chronic Chagas cardiomyopathy (CCC) is the most frequent and severe form of disease, a neglected tropical illness caused by protozoan Trypanosoma cruzi , main cause morbimortality from cardiovascular problems in endemic areas. Although efforts have been made to understand signaling pathways molecular mechanisms underlying CCC, immunological regulated etiological treatment with benznidazole (Bz) has not reported. In experimental Bz combined hemorheological immunoregulatory agent...
Cardiac hypertrophy and dysfunction are a significant complication of chronic Chagas disease, with heart failure, stroke, sudden death related to disease progression. Thus, understanding the signaling pathways involved in chagasic cardiac may provide potential targets for pharmacological therapy. Herein, we investigated implication focal adhesion kinase (FAK) pathway triggering hypertrophic phenotype during acute T. cruzi infection. C57BL/6 mice infected (Brazil strain) were evaluated...
Lutzomyia longipalpis-derived cell line (Lulo) has been suggested as a model for studies of interaction between sandflies and Leishmania.Here, we present data proteomic gene expression analyses Lulo related to interactions with Leishmania (Viannia) braziliensis.Lulo protein extracts were analysed through combination two-dimensional gel electrophoresis mass spectrometry resulting spots further investigated in silico identify proteins using Mascot search and, afterwards, sequences applied...
The Schistosoma mansoni venom allergen-like protein (SmVAL) superfamily is a collection of at least 29 molecules that have been classified into two distinctive groups (Group 1 and Group 2 SmVALs). fundamental basis for SmVAL segregation relates to signal peptide conserved cysteine retention (present in all SmVALs, but absent These structural differences led the hypothesis most found as components schistosome excretory/secretory (E/S) products, predominantly interact with their environment...
INTRODUCTION: High percentages of structural identity and cross-immunoreactivity have been reported between potato apyrase Schistosoma mansoni ATP diphosphohydrolase (SmATPDases) isoforms, showing the existence particular epitopes shared these proteins. METHODS: Potato was employed using ELISA, western blot, mouse immunization methods to verify IgE reactivity. RESULTS: Most schistosomiasis patient’s (75%) serum seropositive for this protein recognized blotting, suggesting that parasite plant...