A5024572338- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Trypanosoma species research and implications
- Luminescence Properties of Advanced Materials
- Carbon and Quantum Dots Applications
- Gut microbiota and health
- Research on Leishmaniasis Studies
- Helminth infection and control
- Luminescence and Fluorescent Materials
- RNA Research and Splicing
- HIV/AIDS drug development and treatment
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- Clostridium difficile and Clostridium perfringens research
- Pneumocystis jirovecii pneumonia detection and treatment
Aberystwyth University
2019-2024
Western University
2023
Institute of Biological, Environmental and Rural Sciences
2019-2022
α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins lipids. Mutations in the human genes encoding either enzyme lead to neurological neuromuscular impairments seen both Fabry- Schindler/Kanzaki- diseases. Here, we investigate whether parasitic blood fluke Schistosoma mansoni , neglected tropical disease schistosomiasis, also contains functionally important...
Praziquantel represents the frontline chemotherapy used to treat schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke schistosomes. While this drug is safe, its inability kill all schistosome lifecycle stages within human host often requires repeat treatments. This limitation, amongst others, has led search for novel anti-schistosome replacement or combinatorial chemotherapies. Here, we describe repositioning strategy assess anthelmintic...
Anoplocephala perfoliata is a neglected gastro-intestinal tapeworm, commonly infecting horses worldwide. Molecular investigation of A. hampered by lack tools to better understand the host–parasite interface. This interface likely influenced parasite derived immune modulators released in secretome as free proteins or components extracellular vesicles (EVs). Therefore, adult RNA was sequenced and de novo assembled generate first transcriptome. In addition, excretory secretory products (ESP)...
Abstract Persistent luminescence (PersL) is an optical phenomenon which allows for materials to emit after ceasing excitation. The long‐lasting ascribed the presence of trap states, can be exploited through introduction various dopants and post‐synthesis treatment. In this study, ZnGa 2 O 4 : Cr 3+ (CZGO), one most widely investigated near‐infrared‐emitting PersL materials, synthesized in form nanoparticles, incorporated into amorphous calcium phosphate (ACP) a luminescent nanocomposite with...
Abstract Mounting evidence of the occurrence direct and indirect interactions between human blood fluke, Schistosoma mansoni , gut microbiota rodent models raises questions on potential role(s) latter in pathophysiology hepatointestinal schistosomiasis. However, substantial differences both composition function laboratory rodents that humans hinders an in-depth understanding significance such for Taking advantage availability a microbiota-associated mouse model (HMA), we have previously...
The Schistosoma mansoni venom allergen-like protein (SmVAL) superfamily is a collection of at least 29 molecules that have been classified into two distinctive groups (Group 1 and Group 2 SmVALs). fundamental basis for SmVAL segregation relates to signal peptide conserved cysteine retention (present in all SmVALs, but absent These structural differences led the hypothesis most found as components schistosome excretory/secretory (E/S) products, predominantly interact with their environment...
Abstract Background Praziquantel represents the frontline chemotherapy used to treat schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro-parasitic blood fluke schistosomes. While this drug is safe, its inability kill all schistosome lifecycle stages within human host often requires repeat treatments. This limitation, amongst others, has led search for novel anti-schistosome replacement or combinatorial chemotherapies. Here, we describe repositioning strategy...
Abstract α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins lipids. Mutations in the human genes encoding either enzyme lead to neurological neuromuscular impairments seen both Fabry- Schindler/Kanzaki-diseases. Here, we investigate whether parasitic blood fluke Schistosoma mansoni, neglected tropical disease schistosomiasis, also contains functionally...