A5023962575- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Renal cell carcinoma treatment
- HER2/EGFR in Cancer Research
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Respiratory Support and Mechanisms
- Thermal Regulation in Medicine
- Estrogen and related hormone effects
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Breast Lesions and Carcinomas
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Head and Neck Cancer Studies
- Ovarian cancer diagnosis and treatment
- Cerebrovascular and Carotid Artery Diseases
- Endometrial and Cervical Cancer Treatments
- Melanoma and MAPK Pathways
Princess Grace Hospital Centre
2013-2025
Institut Curie
2011-2012
Sorbonne Paris Cité
2011
Université Paris Cité
2010-2011
Hôpital Européen Georges-Pompidou
2008-2011
Délégation Paris 5
2010-2011
Assistance Publique – Hôpitaux de Paris
2008-2011
Hôpital Européen
2008-2010
Purpose Because of atypical response imaging patterns in patients with metastatic non-small cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICPIs), new biomarkers are needed for a better monitoring treatment efficacy. The aim this prospective study was to evaluate the prognostic value volume-derived positron-emission tomography (PET) parameters on baseline and follow-up 18 F-fluoro-deoxy-glucose PET ( F-FDG-PET) scans compare it conventional Response Criteria Solid Tumors...
The aims of this cohort study were to evaluate initial tumor hypoxia in metastatic renal cell carcinoma (mRCC) and its changes after sunitinib treatment, using <sup>18</sup>F-fluoromisonidazole PET/CT, investigate the possible prognostic value or under therapy. <b>Methods:</b> Antiangiogenic-naive patients with mRCC prospectively enrolled study. Before initiation sunitinib, CT defined up 10 targets that assessed at 1 6 mo according response evaluation criteria solid tumors (RECIST)....
Two mitogen-activated protein kinase (MAPK2, also known as MEK) inhibitors were assessed with <sup>18</sup>F-FDG PET in separate phase I clinical studies, clearly illustrating the potential of metabolic imaging for dose, dosing regimen, and compound selection early-phase trials utility predicting nonresponding patients. <b>Methods:</b><sup>18</sup>F-FDG data collected during 2 independent, I, dose-escalation novel MEK (RO5126766 RO4987655). acquisition procedures standardized between trials,...
Purpose To compare the accuracy of a single 20-second deep-inspiration breath hold (DIBH) in fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed (CT) to that with conventional free-breathing (FB) whole-body PET/CT for assessment, characterization, and quantification lung lesions terms blurring effect respiratory motion. Materials Methods Institutional review board approval was obtained, requirement obtain informed consent waived. A preclinical study performed test population...
We evaluated the prognostic value of immunotherapy-induced organ inflammation observed on 18FDG PET in patients with non-small cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICPIs).Data from IIIB/IV NSCLC included two different prospective trials were analyzed. PET/CT exams performed at baseline (PETBaseline) and repeated after 7-8 weeks (PETInterim1) 12-16 (PETInterim2) treatment, using iPERCIST for tumor response evaluation. The occurrence abnormal uptake, deemed to be due...
Purpose Physiological myocardial accumulation of FDG impairs the diagnosis inflammatory/infectious or tumoral detection by PET/CT. We prospectively evaluated addition, 3 hours before imaging, an intravenous 100-mL lipid emulsion infusion (Intralipid) to a high-fat, low-carbohydrate diet (HFLCD) for at least 2 meals followed fast 6 12 in patients referred inflammation, endocarditis, cardiac paracardiac masses, intracardiac device, prosthetic valve infections. Methods Data 58 consecutively...
4626 Background: We prospectively assessed the prognostic value 18F-MISO PET-CT in patients (pts) with mRCC before primary sunitinib treatment and after 28 days of (4 weeks on, 2 off). Methods: Non-renal targets were defined at inclusion by CT-scan progression evaluated according to RECIST criteria 1 6 months. Target metastasis hypoxia was visually or target blood (B) ratio (T/B) calculated as tumour maximal standard uptake (SUV) circulating SUV computed on a region interest over thoracic...
Abstract Purpose The main objective of this study was to evaluate the ability a large field Cadmium Zinc Telluride (CZT) camera estimate thyroid uptake (TU) on single photon emission computed tomography (SPECT) images with and without attenuation correction (Tomo-AC Tomo-NoAC) compared Planar acquisition in series 23 consecutive patients. secondary determine radiation doses for tracer administration additional Computed Tomography (CT) scan. Methods Cross-calibration factors were determined...
We aimed to better understand the pathophysiology of SARS-CoV-2 pneumonia in non-critically ill hospitalized patients secondarily presenting with clinical deterioration and increase oxygen requirement without any identified worsening factors.We consecutively enrolled or biological evidence for superinfection, left ventricular dysfunction whom a pulmonary embolism was discarded by computed tomography (CT) angiography. investigated lung ventilation perfusion (LVP) LVP scintigraphy, and, 24 h...
Abstract Background The Memorial Sloan Kettering Cancer Center-Breast Nomogram (MSKCC-BCN) predicts additional nodal metastasis in patients with positive sentinel lymph node (SLN). This statistical tool does not include HER2 status. It has been shown that the interaction covariate between estrogen receptor (ER) and status was a determinant of SLN positivity. purpose our study to determine if accuracy MSKCC BCN could be enhanced new variables. Patients methods: Our dataset consisted 2769...
Abstract Background: The molecular subtypes of breast cancer have different axillary status. A new nomogram including the interaction covariate between estrogen receptor (ER) and HER2 status has been recently published (Reyal et al. PLOSone, may 2011) allows to identify before surgery patients with a high risk positive sentinel lymph node (SLN). purpose our study was validate this model on an independent population. Patients methods: We studied 755 consecutive treated for operable biopsies...
e21068 Background: In patients with non-small cell lung cancer (NSCLC) treated immune checkpoint inhibitors (ICPI), individual clinical, biological, and imaging prognostic biomarkers have recently been identified. However, the combination of these has not yet studied. This study aims to analyse various biological 18 FDG PET/CT parameters using machine-learning algorithms build more accurate models NSCLC response ICPI. Methods: The exploratory cohort consisted metastatic NSCLC, either...
Le nomogramme du Memorial Sloan Kettering Cancer Center (MSKCC) prédit la probabilité d'envahissement axillaire résiduel chez les patientes traitées pour un cancer sein ayant ganglion sentinelle (GS) positif. Cet outil n'inclut pas le statut HER2. Il a été montré récemment que l'interaction entre présence de récepteurs aux oestrogènes (RO) et HER2 était déterminant positivité GS [1]. L'objectif notre étude déterminer si MSKCC pouvait être amélioré par l'inclusion nouvelles variables, dont
Les sous-types moléculaires de cancer du sein ont des statuts axillaires différents. Un nouveau nomogramme incluant l'interaction entre les récepteurs aux oestrogènes (RO) et le statut HER2 a récemment été publié permet d'identifier, avant la chirurgie, patientes ayant un haut risque d'atteinte ganglion sentinelle axillaire (GS) [1]. L'objectif notre étude était valider ce modèle sur une population indépendante.