Abstract The prevention of implant-associated infections has been increasing clinically in orthopedic surgery. Hydroxyapatite with antibacterial properties was synthesized using a microwave-assisted combustion method. High crystallinity at low temperature can be achieved this hydroxyapatite exhibited superior clear zone for both Gram-positive and Gram-negative bacteria. Electron spin resonance (ESR) X-ray photoelectron spectroscopy (XPS) were used the radical investigation. application...

Oxidative stress plays a crucial role in chronic nasal disorders, contributing to inflammation, tissue damage, and impaired mucosal function, highlighting the need for targeted therapies. Recent advancements drug delivery systems have expanded their applications treating respiratory inflammatory conditions. Among these, hydrogel-based offer prolonged release of active pharmaceutical ingredients (APIs), enhancing therapeutic efficacy reducing dosing frequency. This study initially evaluates...

Porous hydroxyapatite (HAp) ceramics have been widely used in several biomedical applications. However, efforts to enhance the porous structure HAp often lead a decline their mechanical properties. In present study, by adding small amount of aluminum nitride (AlN) nanoparticles ceramics, we achieved formation with slight change grain size and The starting powder was obtained from natural source bovine bone. HAp/xAlN nanocomposites were fabricated simple conventional technique. 0.06 mol%...

This study deals with synthesizing hydroxyapatite–calcium sulfate bone cements or HAP– x CaS for repair.

Curcumin is one of the most promising natural therapeutics for use against Alzheimer's disease. The major limitations curcumin are its low oral bioavailability and difficulty in permeating blood-brain barrier. Therefore, designing a delivery system to overcome must be employed. KLVFF, peptide known as an amyloid blocker, was used this study targeting moiety develop targeted drug system. A prototype transnasal KLVFF conjugated microemulsions containing (KLVFF-Cur-ME) nose-to-brain fabricated....

Filariasis is emerging as a public health concern in tropical and subtropical areas. an endemic problem commonly found southeast Asian countries. Using the PCR-restriction fragment length polymorphism (PCR-RFLP) of ITS1 region with Vsp I, overall prevalence rates Dirofilaria immitis (12.2% (41/337); 95% confidence interval: 9.1–16.1%) Brugia pahangi (8.3% (28/337); 5.8–11.8%) were determined based on 337 free-roaming community dogs from 20 districts Northern Thailand. Microfilaremia was only...

Abstract Background Polymeric sponge technique is recommended for developing the desired porosity of Biphasic calcium phosphate (BCP) which may favor bone regeneration. Purpose To investigate healing BCP with ratio HA30/β‐TCP70 (HA30) and HA70/β‐TCP30 (HA70) polymeric preparation, compare to commercial (MBCP+TM). Materials Methods were tested X‐ray diffraction (XRD) pattern scanning electron microscope (SEM) analysis. In eight male pigs, six calvarial defects created in each subject. The...

The pilot study aimed to investigate the effects of GAMS on oral microbiota in healthy dog subjects. Thirty-eight dogs were recruited and randomly allocated placebo (n = 19) treatment groups 19). treated with mouth spray once daily for 42 days. changes gingival index (GI), plaque (PI), calculus (CI) measured at baseline (day 0) end (42nd day). microbial composition representative (placebo, n 7; treatment, 7) also evaluated study. Oral was assessed by sequencing. sequences annotated using...

Curcumin is a potent natural compound used to treat Alzheimer's disease (AD). However, the clinical usefulness of curcumin AD restricted by its low oral bioavailability and difficulty permeating blood-brain barrier. To overcome such drawbacks, various alternative strategies have been explored, including transnasal route. rapid mucociliary clearance in nasal cavity major hindrance drug delivery. Thus, designing delivery system for lengthen contact period between mucosa must be employed. This...

The coverage of rabies vaccinations has been reported at 70–80% dogs in annual reports. However, there are still outbreaks among humans and Thailand, thus indicating the necessity ensuring seroprevalence vaccinated efficacy human immunization. A cost effective easy competitive enzyme-linked immunosorbent assay (CEE-cELISA) was developed here for monitoring protective immunity against virus dog serum samples using monoclonal antibody clone 1-46-12, which recognizes a conformational epitope G...

Background The feline viral rhinotracheitis, calicivirus, and panleukopenia (FVRCP) vaccine, prepared from viruses grown in the Crandell-Rees kidney cell line, can induce antibodies to cross-react with tissues. Objectives This study surveyed prevalence of autoantibodies tissues their association frequency FVRCP vaccination. Methods Serum samples kidneys were collected 156 live 26 cadaveric cats. Antibodies that bind antigen determined by enzyme-linked immunosorbent assay (ELISA),...

Pathological mandibular fracture after dental extraction usually occurs in dogs with moderate to severe periodontitis. A nanohydroxyapatite-based hydrogel (HAP hydrogel) was developed diminish the limitations of hydroxyapatite for post-extraction socket preservation (PSP). However, effect HAP has still not been widely investigated. Moreover, there are few studies on PSP suffering from clinical The purpose this study evaluate effectiveness In five periodontitis, first molar (309 and 409) each...

This research aimed to assess the occurrence of bacterial pathogens and their antimicrobial resistance in dogs presenting with canine periapical tooth abscesses. Sample swabs were performed on 45 who had undergone dental surgery between January 2019 August 2020 at Veterinary Teaching Hospital, Chiang Mai University. Samples analyzed within 24 hours Diagnostic Laboratory, University identify any species investigate potential susceptibility according CLSI guidelines. A high proportion...

This pilot study aimed to investigate the effects of gallic acid-containing mouth spray on oral microbiota in healthy cat subjects. Forty cats were recruited and randomly allocated control (G1; n = 20) treatment groups (G2; 20). The treated with twice daily for 42 days. changes gingival index (GI) plaque (PI) measured at baseline (day 0) end (42nd day). microbial composition representative animals (control, 9; treatment, 8) also evaluated study. Oral was assessed by amplifying V1-V3 region...

A sterilization program is implied to control the cat population and set up as national rabies activities. In Thailand, a few studies have been conducted on postoperative complications undesired incidents after massive sterilization. This study determined incidence of short-term in cats with or without antibiotic administration risk surgical complications. The investigators clinical trial study. Female (n=492) who participated Chiang Mai municipal birth activity were assessed recorded those...

Rabies is a challenging human and animal health concern that requires multisectoral interdisciplinary strategy for prevention control. The aim of this study was to investigate One Health perspectives on long-term rabies in disease-free subdistricts Chiang Mai, Thailand. A qualitative using semi-structured interviews carried out three rabies-free communities with diverse demographics, the results were analyzed thematic analysis. findings gathered from 36 equal proportions urban, suburban,...

Many developing countries have recently faced public health challenges due to outbreaks of human rabies, while some areas remained free from the disease. The aim this study was identify keys good knowledge, attitude and practice (KAP) in rabies-free Thailand provide a functional model for rabies prevention endemic zones. A cross-sectional conducted using questionnaire conjunction with interviews that were designed elicit relevant information. Multivariate logistic regression analysis content...

In the present work, characteristic of β-tricalcium phosphate (β-TCP) powder was investigated for its film coating on a Ti6Al4V metallic biomaterial. The β-TCP synthesized by solid-state reaction technique at different temperatures. formed temperatures 900-1000 oC, while α-tricalcium (α-TCP) occurred higher (≥1000 oC). Crystallite size increased with increasing temperature, but it decreased than 1000 oC due to formation α-TCP. Furthermore, amount α-TCP phase temperature. However, maximum...

Chronic kidney disease is considered to be most common in geriatric domestic cats.It has been reported that the feline viral rhinotracheitis, calicivirus, and panleukopenia (FVRCP) vaccine prepared from Crandell-Rees (CRFK) cell line can induce crossreactions of antibodies with tissues.As an anti-cat antibody was not available commercially for this study autoantibody cats, purpose produce rabbits further cats after FVRCP vaccination.Kidney proteins cadaveric were extracted immunized into...

Since the removal of a metallic interlocking nail system leaves blank cavity inside healed bone, bioactive and biodegradation materials have been used instead to induce bone formation eliminate complications material procedure. The previous study presented possibility an fabrication from polylactic acid (PLA), polycaprolactone (PCL), hydroxyapatite (HA) using 3D printing, namely fused filament (FFF), for canine diaphyseal fractures. Therefore, finite element analysis (FEA) was predict...