A5034373531- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Effects of Radiation Exposure
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Radiation Dose and Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Radiopharmaceutical Chemistry and Applications
- Colorectal Cancer Treatments and Studies
- Cancer and Skin Lesions
- Cancer Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Bacterial Infections and Vaccines
- Advanced MRI Techniques and Applications
- Blood disorders and treatments
- Cancer Genomics and Diagnostics
- Radiation Therapy and Dosimetry
- Chemotherapy-related skin toxicity
- Brain Metastases and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Nail Diseases and Treatments
UNSW Sydney
2021-2022
Aarhus University Hospital
2011-2021
Westmead Hospital
2019
Royal Marsden Hospital
2016
Institute of Cancer Research
2016
Aarhus University
2013
Understanding the dose-response of lung in order to minimize risk radiation pneumonitis (RP) is critical for optimization cancer radiotherapy. We propose a method combine relationship RP landmark QUANTEC paper with known clinical factors, enable individual prediction. The approach validated an independent dataset.The prevalence factors patient populations underlying analysis was estimated, and previously published adjust relationships employed. Effect size estimates (odds ratios) were drawn...
Intensity-modulated radiotherapy (IMRT) in locally advanced non-small cell lung cancer (NSCLC) allows treatment of patients with large tumour volumes, but radiation pneumonitis (RP) remains a dose limiting complication. The incidence severe RP using three-dimensional (3D) conformal radiotherapy, was previously reported to be 17%, 2% lethal RP. aim this study monitor the following introduction IMRT.IMRT delivered 4-8 beam arrangements and introduced three phases. In phase I, 12 were treated...
Palmar-plantar erythrodysesthesia (PPE), also called hand-foot syndrome, is a relatively common dermatologic toxic reaction associated with cytotoxic chemotherapy that can limit the use of such drugs. Definitive prevention and treatment strategies for PPE have not yet been established. We present patient recurrent ovarian cancer developing severe syndrome after pegylated liposomal doxorubicin. A review relevant literature concerning pathophysiology, preventive measures management given....
The purpose of the study was to assess dose and time dependence radiotherapy (RT)-induced changes in regional lung function measured with single photon emission computed tomography (SPECT) relate these symptomatic endpoint radiation pneumonitis (RP) patients treated for non-small cell cancer (NSCLC).NSCLC scheduled receive curative RT minimum 60 Gy were included prospectively study. Lung perfusion SPECT/CT performed before three months after RT. Reconstructed data registered treatment...
Functional avoidance radiation therapy (RT) aims at sparing functional lung regions. The purpose of this simulation study was to evaluate the feasibility methodology in RT cancer and characterize achievable dosimetry single photon emission computed tomography (SPECT) guided treatment planning.Fifteen consecutive patients were included planned for definitive 60-66 Gy 2-Gy fractions. Two plans optimized: a standard CT-plan, SPECT-plan. objective reduce dose highly subvolumes without...
Radiation therapy (RT) plays a key role in curative-intent treatment for locally advanced lung cancer. induced pulmonary toxicity can be significant some patients and becomes limiting factor radiation dose, suitability treatment, as well post quality of life the newly introduced adjuvant immunotherapy. Modern RT techniques aim to minimise dose lungs, without accounting regional distribution function. Many cancer have differences function due smoking chronic co-morbidity. Even though...
337 Background: Little evidence exists on 2 nd line therapy for gemcitabine resistant patients. The combination of oxaliplatin (Ox) and 5-FU has shown efficacy in small trials. We wanted to establish a tolerable dose the irinotecan, cetuximab everolimus(ICE), test it vs. capecitabine (Cap) Ox randomized phase I/II setting. Methods: Patients were initially recruited 3+3 finding design with an expanded MDT cohort. After establishing MDT; patients between ICE (at MDT-1) CapOx (Cap: 1250 mg/m...
In radiotherapy (RT) of lung cancer, dose to functional (FL) volumes segmented with two different methods (perfusion SPECT (Q-SPECT) and 4D-CT (4D) ventilation (V)) have been shown correlate the incidence radiation pneumonitis (RP). This study aims compare FL identified by both methods.Thirty cancer patients had a 4D Q-SPECT prior treatment. Seventeen these also (V-SPECT). sub-volumes were automatically, using cut-off values. The compared in terms overlap fraction (OF) relative minimal...
Conclusion:AHRT is a reasonable alternative to conventional fractionated radiotherapy in stage I-II NSCLC without access SABR and III patients unfit for concurrent chemotheraphy.In both groups, treatment was well tolerated grade 3 or higher treatment-related toxicity.PS >2 an independent risk factor OS CSS.
Conclusion:The proposed iterative 4D CBCT reconstruction algorithm is more than an order of magnitude faster other algorithms described in the literature.It produces sharp, streak free images from standard 60s acquisitions used for 3D CBCT.For purposes such as patient setup and verification tumour motion, fast presented enables online usage a part clinical treatment routine.
e15238 Background: Little evidence exists on 2nd line therapy for gemcitabine resistant patients. The combination of oxaliplatin (Ox) and 5-FU has shown efficacy in small trials. We wanted to establish a tolerable dose the irinotecan, cetuximab everolimus(ICE), test it vs. capecitabine (Cap) Ox randomized phase I/II setting. Methods: Patients were initially recruited 3+3 finding design with an expanded MDT cohort. After establishing MDT; patients between ICE (at MDT-1) CapOx (Cap: 1250 mg/m2...