A5005805602- Protein Kinase Regulation and GTPase Signaling
- Emotional Labor in Professions
- Muscle Physiology and Disorders
- Advanced Malware Detection Techniques
- Cancer-related Molecular Pathways
- Wnt/β-catenin signaling in development and cancer
- Occupational Health and Safety Management
- Spine and Intervertebral Disc Pathology
- Protease and Inhibitor Mechanisms
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- Cellular Mechanics and Interactions
Korea National Institute of Health
2016
Chosun University
2010-2012
Chungbuk National University
2006-2010
Cell migration requires the coordinated spatiotemporal regulation of actomyosin contraction and cell protrusion/adhesion. Nonmuscle myosin II (MII) controls Rac1 Cdc42 activation, protrusion focal complex formation in migrating cells. However, these mechanisms are poorly understood. Here, we show that MII interacts specifically with multiple Dbl family guanine nucleotide exchange factors (GEFs). Binding is mediated by conserved tandem homology–pleckstrin homology module, catalytic site GEFs,...
p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and survival. Deregulation PAK activity contributes to the pathogenesis various human diseases, including cancer neurological disorders. Using an ELISA-based screening protocol, we identified naphtho(hydro)quinone-based small molecules that allosterically inhibit activity. These interfere with interactions between p21-binding domain (PBD) PAK1 Rho GTPases by binding PBD. Importantly, they full-length PAKs...