A5047549116- Polyamine Metabolism and Applications
- Plant Molecular Biology Research
- Plant Stress Responses and Tolerance
- Plant tissue culture and regeneration
- Plant responses to water stress
- Plant Reproductive Biology
- Legume Nitrogen Fixing Symbiosis
- Aluminum toxicity and tolerance in plants and animals
- Bone health and treatments
- Bone Metabolism and Diseases
- Carbon and Quantum Dots Applications
- Plant Micronutrient Interactions and Effects
- Polysaccharides and Plant Cell Walls
- Prostate Cancer Treatment and Research
- GABA and Rice Research
- Plant responses to elevated CO2
- Plant nutrient uptake and metabolism
- Amino Acid Enzymes and Metabolism
- Light effects on plants
- Plant Parasitism and Resistance
- Nanoparticles: synthesis and applications
University of Szeged
2019-2024
Semmelweis University
2023-2024
HUN-REN Szegedi Biológiai Kutatóközpont
2019-2023
Institute of Plant Biology
2019-2023
Hungarian Research Network
2022-2023
Hungarian Academy of Sciences
2019-2022
Osteoclasts play a central role in cancer-cell-induced osteolysis, but the molecular mechanisms of osteoclast activation during bone metastasis formation are incompletely understood. By performing RNA sequencing on mouse breast carcinoma cell line with higher bone-metastatic potential, here we identify enzyme CYP11A1 strongly upregulated osteotropic tumor cells. Genetic deletion Cyp11a1 cells leads to decreased number metastases does not alter primary growth and lung mice. The product...
Abstract In vitro regeneration of Arabidopsis from roots is generally achieved via indirect organogenesis. First, transdifferentiation lateral root primordia to calli by a balanced auxin-to-cytokinin ratio that followed the induction shoot meristem formation using high cytokinin level. Here we demonstrate if explants were transferred onto hormone-free medium after transient (4-days) treatment, embryogenic marker genes ( LEC1, LEC2, FUS3 ) started be expressed. App. 50% foci developed into...
Plants can be regenerated from various explants/tissues via de novo shoot meristem formation. Most of these regeneration pathways are indirect and involve callus Besides plant hormones, the role polyamines (PAs) has been implicated in processes. Interestingly, lateral root primordia (LRPs) Arabidopsis directly converted to meristems by exogenous cytokinin application. In this system, no formation takes place. We report that level PAs, especially spermidine (Spd), increased during conversion...
Lateral root primordia (LRPs) of Arabidopsis can be directly converted to shoot meristems (SMs) by the application exogenous cytokinin. Here, we report that POLYAMINE OXIDASE 5 (AtPAO5) contributes this process, since rate SM formation from LRPs was significantly lower in pao5-2 knockout mutant. Furthermore, presented experiments showed AtPAO5 influences via controlling thermospermine (T-Spm) level. Gene expression analyses supported view mutation as well T-Spm downregulate class 3...
Despite being a worldwide problem, responses of crops to zinc (Zn) deficiency is largely unknown. This study examines the effects limited Zn supply in Brassica napus. The decreased content nutrient solution caused reduced tissue concentrations and K, Ca, Mg levels were detected leaves. For Zn, Fe, Mo inhomogeneous distribution was induced by limitation. Suboptimal shoot root biomass altered structure. sugars sugar phosphates (e.g. glucose, glucose-6-phosphate etc.) suggesting disturbance...
In addition to their beneficial effects on plant physiology, multi-walled carbon nanotubes (MWCNTs) are harmful plants in elevated concentrations. This study compared the of two doses MWCNT (10 and 80 mg/L) Brassica napus Solanum lycopersicum seedlings focusing nitro-oxidative processes. The presence MWCNTs was detectable root hypocotyl both species. Additionally, transmission electron microscopy analysis revealed that heavily transformed within cells forming large aggregates. uptake...
Tumors often metastasize to the bone and osteolytic metastases, where bone-resorbing osteoclasts are activated, leading pathological fractures increased mortality in patients. Osteoclasts play a central role cancer cell-induced osteolysis, but molecular mechanisms of osteoclast activation during metastasis formation incompletely understood. Solid tumors were previously considered induce differentiation indirectly via osteoblasts, however, based on our results, cell-derived soluble factors...
Polyamines play an important role in developmental and environmental stress responses plants. Polyamine oxidases (PAOs) are flavin-adenine-dinucleotide-dependent enzymes associated with polyamine catabolism. In this study, 14 genes were identified the tobacco genome that code for PAO proteins being named based on their sequence homology Arabidopsis PAOs (AtPAO1-5): NtPAO1A-B; NtPAO2A-C, NtPAO4A-D, NtPAO5A-E. Sequence analysis confirmed gene family of allopolyploid hybrid Nicotiana tabacum is...