A5101604552- interferon and immune responses
- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
- Antimicrobial Peptides and Activities
- Toxoplasma gondii Research Studies
- RNA modifications and cancer
- Cytomegalovirus and herpesvirus research
- Parasitic Infections and Diagnostics
- Veterinary medicine and infectious diseases
- Functional Brain Connectivity Studies
- Microbial infections and disease research
- Animal Nutrition and Physiology
- Alzheimer's disease research and treatments
- Reproductive System and Pregnancy
- Medicinal Plants and Neuroprotection
- Seaweed-derived Bioactive Compounds
- T-cell and B-cell Immunology
- Bioinformatics and Genomic Networks
- Pediatric health and respiratory diseases
- Lymphatic System and Diseases
- Wastewater Treatment and Nitrogen Removal
- Biomarkers in Disease Mechanisms
University College London
2024
MRC Unit for Lifelong Health and Ageing
2024
Shanghai Ocean University
2022-2023
Hunan Agricultural University
2017-2023
Yanbian University
2021
Second Hospital of Shandong University
2008
Tianjin University of Science and Technology
2008
Diarrhea caused by Escherichia coli (E. coli) is one of the most common diseases that affects growth and development poultry. This study was conducted to investigate synergistic effects traditional Chinese medicine (TCM) combined with probiotics against E. infection its mechanism in broiler chickens. The optimal proportion formula TCM screened orthogonal test range analysis method; vitro antibacterial activity based on Oxford cup method. Isolated pathogenic injected subcutaneously into neck...
Teleost type I interferons (IFNs) are categorized into group and II subgroups that bind to distinct receptors activate antiviral responses. However, the interaction between ifn ligands has not fully been understood. In this study, crystal structure of grass carp [ Ctenopharyngodon idella ( Ci )] IFNa solved at 1.58Å consists six helices. The displays a typical IFNs with straight helix F lacks element in AB loop. Superposition modeling identified several key residues involved receptors. It...
Abstract Gene duplication leads to subfunctionalization of paralogs. In mammals, IFN-γ is the sole member type II IFN family and binds a receptor complex consisting IFN-γR1 IFN-γR2. teleost fish, its receptors have been duplicated due teleost-specific whole-genome event. this study, functions an IFN-γ–related (IFN-γrel) cytokine were found be partially retained relative in grass carp (Ctenopharyngodon idella [CiIFN-γrel]). CiIFN-γrel upregulated expression proinflammatory genes but had lost...
Interferon regulatory factors (IRFs) are central in the regulation of interferon-mediated antiviral immunity. Here, we reported that IRF2a suppressed interferon response and promoted virus replication zebrafish.
PLAAT1 is a member of the PLAAT protein family and plays important roles in tumor suppression, transglutaminase activation peroxisomal biogenesis. Recently, has been shown to promote degradation p53 cellular organelles such as mitochondria, endoplasmic reticulum lysosome. In this study, we show that inhibits production type I interferon promotes virus replication zebrafish. Overexpression Plaat1 zebrafish cells suppresses antiviral responses replication. Mechanistically, interacts with IRF3...
Our previous reports have shown that Inonotus obliquus polysaccharide (IOP) has protective effects against Toxoplasma gondii (T. gondii) infection in vivo. The aim of the present research is to explore vitro anti-inflammatory IOP and its mechanism RAW264.7 macrophages infected by T. gondii. In this study, it indicated decreased excessive secretion inflammatory cytokines tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), IL-4, IL-6 gondii-infected macrophages....
As a medicinal and edible fungus, Inonotus obliquus has been traditionally used to prevent treat various ailments. polysaccharide (IOP) isolated from I. processes many biological activities, our series of in vivo studies have shown that IOP protects against Toxoplasma gondii infection.This study aimed investigate the vitro immunomodulatory effects its mechanisms on mouse splenic lymphocytes infected with T. gondii.Mouse were tachyzoites, treated different concentrations IOP. The levels...
A cell line, termed ZFIN, was established from the caudal fin of zebrafish and shown to be susceptible spring viremia carp virus (SVCV). The ZFIN cells are epithelial like have a moderate plasmid transfection efficiency 13.9%. Using an RNA-seq approach, differentially expressed genes (DEGs) regulated by SVCV were identified. Infection gave rise 3931 DEGs up-regulated mostly enriched into biological regulation cellular processes, among which pathways for type I interferon signaling response...
Abstract Background Connectome‐based models of disease propagation are used to probe mechanisms pathology spread in neurodegenerative disease. We present our network spreading model toolbox that allows the user compare fits across different and parameters. apply assess whether local amyloid levels affect production pathological tau. Methods Data: Regional tau‐PET amyloid‐PET SUVRs from Alzheimer’s Disease Neuroimaging Initiative (ADNI) study were downloaded September 2023 (demographics...