A5021987548- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- Venomous Animal Envenomation and Studies
- Cell Adhesion Molecules Research
- Toxin Mechanisms and Immunotoxins
- Autoimmune Bullous Skin Diseases
- Rabies epidemiology and control
- Abdominal vascular conditions and treatments
- Viral gastroenteritis research and epidemiology
- Helicobacter pylori-related gastroenterology studies
- Biochemical and Structural Characterization
- Pancreatic and Hepatic Oncology Research
- Animal Virus Infections Studies
- Genetic factors in colorectal cancer
- TGF-β signaling in diseases
- Eosinophilic Esophagitis
- Forensic Toxicology and Drug Analysis
- Pancreatitis Pathology and Treatment
- Pharmacological Effects of Natural Compounds
- Sexual function and dysfunction studies
- Workplace Health and Well-being
- Galectins and Cancer Biology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bacteriophages and microbial interactions
Nordic Bioscience (Denmark)
2019-2024
Central Denmark Region
2024
Cambridgeshire and Peterborough NHS Foundation Trust
2021
University College London
2020
Odense University Hospital
2019
University of Southern Denmark
2019
Technical University of Denmark
2019
Statens Serum Institut
2011-2017
Lund University
2011
Danish Cancer Society
2011
One-third of the world's men are circumcised, but little is known about possible sexual consequences male circumcision. In Denmark (~5% circumcised), we examined associations circumcision with a range measures in both sexes.Participants national health survey (n = 5552) provided information their own (men) or spouse's (women) status and details sex lives. Logistic regression-derived odds ratios (ORs) measured experiences current difficulties desire, needs fulfilment functioning.Age at first...
The black mamba (Dendroaspis polylepis) is one of the most feared snake species African savanna. It has a potent, fast-acting neurotoxic venom comprised dendrotoxins and α-neurotoxins associated with high fatality in untreated victims. Current antivenoms are both scarce on continent present number drawbacks as they derived from plasma hyper-immunized large mammals. Here, we describe development an experimental recombinant antivenom by combined toxicovenomics phage display approach. based...
BackgroundThe potential mutagenic effects of cancer therapies and the growing number young male survivors have given rise to concern about health their offspring.
The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which predominantly derived from long-chain α-neurotoxins. only specific treatment for snakebite envenoming antivenom based on animal-derived polyclonal antibodies. Despite lifesaving importance of these medicines, major limitations safety, supply consistency, and efficacy create a need improved treatments. Here, we describe discovery subsequent optimization recombinant human monoclonal...
<title>Abstract</title> Background Fibrostenotic stricturing disease affects 30–50% of patients with Crohn’s (CD) leading to intestinal resection. Currently, there exists a great medical need identify biomarkers related fibrostenotic strictures for optimized patient management. Thus, we investigated PRO-C16 as biomarker fibrosis in CD. Methods Human serum from two independent cohorts CD (cohort 1: n = 44, cohort 2:n 52), healthy subjects(n 37), and chronic rat dextran sodium sulfate(DSS)...
Extracellular matrix (ECM) homeostasis is highly affected in active inflammatory bowel disease (IBD). The aim of the study was to investigate serological biomarkers type III, IV, and V collagen degradation formation, their association with activity IBD. ECM remodeling serum were measured 162 IBD patients, 110 Crohn’s (CD) 52 ulcerative colitis (UC), 29 healthy donors. Biomarkers III (C3M) formation (PRO-C3), IV (C4M) (PRO-C4), (PRO-C5) using ELISA. Inflammatory assessed endoscopic, clinical,...
Emerging viruses are usually endemic to tropical and sub-tropical regions of the world, but increased global travel, climate change changes in lifestyle believed contribute spread these into new regions. Many cause similar disease symptoms as other emerging or common infections, making unexpected pathogens difficult diagnose. Broad-spectrum pathogen detection microarrays containing probes for all sequenced bacteria can provide rapid identification viruses, guiding decisions about treatment...
Abstract In inflammatory bowel disease (IBD), the chronic inflammation deeply affects intestinal extracellular matrix. The aim of this study was to investigate if remodeling basement membrane type VI collagen associated with pathophysiological changes in Crohn’s (CD) and ulcerative colitis (UC). Serum from IBD patients (CD: n = 65; UC: 107; irritable syndrome: 18; healthy subjects: 20) investigated study. serological biomarkers C6Ma3 (a matrix metalloproteinase (MMP) generated fragment α3...
Impaired intestinal epithelial barrier is highly affected in inflammatory bowel disease. Transmembrane collagens connecting the cells to extracellular matrix have an important role cell homeostasis. Thus, we sought determine whether transmembrane type 23 collagen could serve as a surrogate marker for disease activity patients with Crohn's and ulcerative colitis.
Pancreatic ductal adenocarcinoma (PDAC) is a hard-to-treat cancer due to the collagen-rich (fibrotic) and immune-suppressed microenvironment. A major driver of this phenomenon transforming growth factor beta (TGF-β). TGF-β produced in an inactive complex with latency-associated protein (LAP) that can be cleaved by plasma kallikrein (PLK), hereby releasing active TGF-β. The aim study was evaluate LAP PLK as non-invasive biomarker for PDAC tumor fibrosis. An ELISA developed quantification...
Abstract The monocled cobra ( Naja kaouthia ) is one of the most feared snakes in Southeast Asia. It a highly dangerous species with potent venom deriving its toxicity predominantly from abundant long-chain α-neurotoxins. only specific treatment for snakebite envenoming antivenom, which based on animal-derived polyclonal antibodies. Despite lifesaving importance these medicines over past 120 years, and their ongoing role combating disease, major limitations safety, supply consistency,...
Background: Limited understanding exists regarding effective return-to-work strategies for persons participating in cardiac rehabilitation (CR). Objective: The aim of this study was to explore the association between CR completion and employment status at 6- 18-months post-inclusion within primary healthcare settings Central Denmark Region. Methods: A cohort conducted using data from a non-randomized clinical controlled trial involving with ischemic heart disease attending August 1, 2018,...
Ulcerative colitis (UC) is characterised by superficial inflammation that starts in the rectum and can extend proximally to affect entire colon. Endoscopy used diagnose patients terms of extension disease; however, this invasive cannot always be completed, for example, if colon too severely inflamed. The epithelial endothelial basement membrane (BM) an abundant extracellular matrix (ECM) intestine. Type VIII collagen directly associated with BM C-terminus contains anti-angiogenic signalling...
Abstract Background Endoscopy is a mainstay in ulcerative colitis (UC) for disease activity monitoring. The modified Mayo Endoscopic Score (mMES) UC takes into account extent and hereby additional objectivity can be achieved endoscopic assessment. However, evaluation of the intestinal mucosa time-consuming inconvenient patients. Therefore, surrogate biomarkers examinations are warranted. aim this study was to evaluate serological neo-epitope type IV collagen degradation (C4M) formation...