A5069873239- Malaria Research and Control
- Mosquito-borne diseases and control
- Computational Drug Discovery Methods
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Antifungal resistance and susceptibility
- Epilepsy research and treatment
- Hemoglobinopathies and Related Disorders
- Genetic factors in colorectal cancer
- SARS-CoV-2 and COVID-19 Research
- Research on Leishmaniasis Studies
- Neutropenia and Cancer Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Gut microbiota and health
- Infant Nutrition and Health
- Lymphadenopathy Diagnosis and Analysis
- Insect Pest Control Strategies
- Parasites and Host Interactions
- Global Health and Epidemiology
- Long-Term Effects of COVID-19
- Colorectal Cancer Screening and Detection
- Vestibular and auditory disorders
- Neuroscience of respiration and sleep
University of Kinshasa
2019-2025
The Democratic Republic of Congo (DRC) is one the eight countries with highest burden tuberculosis (TB) in world. public health system inadequate and screening for TB key vulnerable population (KVP), including drug users (DU) not currently done. present study aimed to determine prevalence pulmonary among DU Kinshasa by comparing molecular tests microscopic techniques. A cross-sectional covering 22 townships (out 24) was conducted from October December 2023. Sputum samples were collected DUs...
Abstract Background This study aimed to estimate the socio-economic costs of uncomplicated malaria and explore health care-seeking behaviours that are likely influence these in Democratic Republic Congo (DRC), a country ranked worldwide as second most affected by malaria. Methods In 2017, cross-sectional survey included patients with 64 healthcare facilities from 10 sentinel sites National Malaria Control Programme (NMCP) DRC. A standard questionnaire was used assess patients. Health-related...
Neuromeningeal cryptococcosis (NMC) is a life-threatening opportunistic infection in advanced HIV disease patients (AHDP). It caused by Cryptococcus spp. complexes and mainly occurs sub-Saharan Africa. In this study, we performed molecular characterization antifungal susceptibility profiling of isolates from AHDP Kinshasa (DRC). Additionally, investigated possible association between NMC severity factors the neoformans (Cn) multilocus sequence typing (MLST) profiles. We characterized using...
Abstract Background The national policy for malaria treatment of the Democratic Republic Congo recommends two first-line artemisinin-based combinations uncomplicated malaria: artesunate-amodiaquine and artemether-lumefantrine. This study investigated presence markers associated with resistance to current combination therapy (ACT) in isolates Plasmodium falciparum from failure patients Congo. Methods From November 2018 2019, dried blood spots were taken returning health centres fever within...
Abstract Background Because of the loss chloroquine (CQ) effectiveness, Democratic Republic Congo (DRC)’s malaria treatment policy replaced CQ by sulfadoxine–pyrimethamine (SP) as first-line uncomplicated in 2003, which turn was artemisinin-based combination therapies (ACT) 2005. The World Health Organization (WHO) recommends monitoring anti-malarial drug resistance every 2 years. study aimed to provide baseline data for biennial molecular surveillance comparing from a conducted 2019...
Artemisinin-based combination therapies (ACTs) have been recommended by the World Health Organization (WHO) as first-line treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria since 2005 in Democratic Republic Congo (DRC) and a regular surveillance ACT efficacy is required to ensure effectiveness. Mutations propeller domain pfk13 gene were identified molecular markers artemisinin resistance (ART-R). This study investigated pfk13-propeller polymorphism clinical isolates P....
Abstract Background The loss of chloroquine (CQ) effectiveness has led to its withdrawal from national policies as a first-line treatment for uncomplicated malaria in several endemic countries, such the Democratic Republic Congo (DRC). K76T mutation on pfcrt gene been identified marker CQ resistance and SVMNT haplotype codons 72–76 same associated with amodiaquine (AQ). In DRC, prevalence decreased 100% 2000 63.9% 2014. purpose this study was determine mutations circulating strains...
Due to the lack of both cancer registry and large scale cervical screening in most african countries, only theoretical studies are available. The objective our work was provide epidemiological histopathological characteristics based on concrete observations.This study carried out all cancers (n=5801) collected last 10 years from 5 pathology laboratories Kinshasa; histologic slides (n=1280) were reviewed by at least two pathologists classified according 2014 OMS classification.The accounted...
ABSTRACT Background Although cutaneous mycoses are a global public health problem, very few data available in the Democratic Republic of Congo (DRC). Objectives This study aimed to describe retrospective clinical epidemiology dermatomycosis and their associated risk factors dermatological consultations Kinshasa, DRC. Methods A based on medical records patients seen departments dermatology 2 major hospitals Kinshasa from March 2000 August 2023 was carried out. The diagnosis various types...
Cryptococcal meningitis is mainly caused by Cryptococcus neoformans/C. gattii complex. We compared the clinical, biological, and antifungal susceptibility profiles of isolates from HIV-Infected Patients (HIVIP) with C. neoformans (Cn) versus curvatus/C. laurentii (Cc/Cl) meningitis.Comparative analytical study were conducted. Apart patients' clinical data, following analysis performed results in both groups: biochemical examination, cryptococcal antigen test, India ink staining, culture on...
Abstract Background: The loss of chloroquine (CQ) effectiveness has led to its withdrawal from national policies as a first-line treatment for uncomplicated malaria in several endemic countries, such the Democratic Republic Congo (DRC). K76T mutation on pfcrt gene been identified marker CQ resistance and SVMNT haplotype codons 72–76 same associated with amodiaquine (AQ). In DRC, prevalence decreased 100% 2000 63.9% 2014. purpose this study was determine mutations circulating strains...
Abstract Background The loss of chloroquine (CQ) effectiveness has led to its withdrawal from national policies as first-line treatment for uncomplicated malaria in several endemic countries such the Democratic Republic Congo (DRC). K76T mutation on pfcrt gene been identified a marker CQ resistance and SVMNT haplotype codons 72–76 same associated with amodiaquine (AQ). In DRC, prevalence decreased 100% 2000 63.9% 2014. purpose study was determine mutations P. falciparum circulating strains,...
Breast milk is important for infant health. Some of its benefits are due to the presence a specific population bacteria in microflora. However, microbiome breast influenced by many parameters such as maternal diet, breastfeeding and geographic location. Culture non-culture methods have been used studies this bacterial worldwide. But DR Congo, there was no study reporting use culture-independent techniques characterize diversity human milk. The aim identify 16S rRNA gene from two genera...
Introduction: The diagnosis (Dc) of erytrhocyte rate sedimentation(ERS) allows specific management the patient and his predisposed relatives (PA). Objective: To explore frequency ERS assess potential associations between epidemiological-clinical biological parameters JRC. Methods: Multicentric study conducted 2015 2018 in 4 clinics Kinshasa. Results: Out 50 patients with CRC, 94% (n = 47) were unstable microsatellite positive status (MSI +) against 6% 3) MSI negative (-). mean values...
Mosquitoes transmit serious human diseases, causing millions of deaths worldwide every year and the development resistance to chemical insecticides resulting in rebounding vectorial capacity. In this study, larvicidal bioassays for activities aqueous solutions weak acid [(NH4)2SO4 NaH2PO4] base (Na2CO3 NaHCO3) inorganic salts against late instar larvae disease vectors Anopheles stephensi Culex quinquefasciatus were carried out under laboratory settings. The four showed varied levels after 24...
Abstract Background The Democratic Republic of Congo (DRC) malaria treatment policy recommends two first-line artemisinin-based combination therapies (ACTs) for the uncomplicated malaria: Artesunate-amodiaquine (ASAQ) and Artemether-lumefantrine (AL). This study investigated resistance to ACTs currently in use DRC through molecular markers pfk13, pfcrt pfmdr1 genes Plasmodium falciparum isolated from patients returning retreatment. Methods From November 2018 2019, dried blood spots were...
Abstract Background The loss of chloroquine (CQ) effectiveness has led to its withdrawal from national policies as a first-line treatment for uncomplicated malaria in several endemic countries, such the Democratic Republic Congo (DRC). K76T mutation on pfcrt gene been identified marker CQ resistance and SVMNT haplotype codons 72–76 same associated with amodiaquine (AQ). In DRC, prevalence decreased 100% 2000 63.9% 2014. purpose this study was determine mutations circulating strains P....
Abstract Background The loss of chloroquine (CQ) effectiveness has led to its withdrawal from national policies as first-line treatment for uncomplicated malaria in several endemic countries such the Democratic Republic Congo (DRC). K76T mutation on pfcrt gene been identified a marker CQ resistance and SVMNT haplotype codons 72–76 same associated with amodiaquine (AQ). In DRC, prevalence decreased 100% 2000 63.9% 2014. purpose study was determine mutations P. falciparum circulating strains,...