A5061310711- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Acute Myeloid Leukemia Research
- Ocular Oncology and Treatments
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Immune Response and Inflammation
- Neuroblastoma Research and Treatments
- Glioma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Child and Adolescent Health
- Cancer therapeutics and mechanisms
- Neonatal Respiratory Health Research
- Neutropenia and Cancer Infections
- Brain Metastases and Treatment
- Immunodeficiency and Autoimmune Disorders
- Parasitic Infections and Diagnostics
- Chronic Myeloid Leukemia Treatments
- Retinoids in leukemia and cellular processes
- Cancer Risks and Factors
- CNS Lymphoma Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
Secretaria de Salud
2014-2025
Hospital Infantil de México Federico Gómez
2015-2025
Universidad Nacional Autónoma de México
2020
Mexican Social Security Institute
2014
Columbia University
2014
Instituto Nacional de Pediatria
2007
Worldwide, acute leukemia is the most common type of childhood cancer. It particularly in Hispanic populations residing United States, Costa Rica, and Mexico City. The objective this study was to determine incidence children who were diagnosed treated public hospitals City.Included those children, under 15 years age residents City, 2006 2007 with leukemia, as determined by using International Classification Childhood Cancer. average annual rates (AAIR), standardized (SAAIR) per million...
Resistance to chemotherapy hinders the successful treatment of acute lymphoblastic leukemia (ALL). The multi-drug resistance-1 (MDR1/ABCB1) gene encodes P-glycoprotein (P-gp), which plays an important role in chemoresistance; however, its transcriptional regulation remains unclear. We investigated YY1 MDR1 and relation ALL outcomes. Analysis promoter revealed four putative YY1-binding sites, we analyzed using a reporter system ChIP analysis. silencing resulted inhibition expression function....
Abstract Background: More invasive retinoblastoma, characterized by increased morbidity and mortality, with lower rates of eye salvage higher extraocular dissemination, seems more prevalent in resource-poor countries. The relationship diagnostic delay (lag time) sociodemographic factors on the extent disease at diagnosis has not been examined separately for unilateral bilateral retinoblastoma. Methods: At diagnosis, consenting parents 179 Mexican children retinoblastoma were interviewed...
Amifostine has emerged as a pancytoprotectant shown protection against nephrotoxicity, neurotoxicity and ototoxicity in preclinical studies. Methods: We designed prospective comparative randomized trial to evaluate the cytoprotective effects of amifostine patients with osteosarcoma receiving cisplatin doxorrubicin. Patients were evaluated for renal, hearing cardiac toxicity. Results: included 28 patients, mean age was 11.6 years, five had metastatic disease. Fifteen received 13 did not. 20%...
For a child to develop acute leukaemia (AL), environmental exposure may not be sufficient: interaction with susceptibility factor the disease, such as Down syndrome (DS), also necessary. We assessed whether breastfeeding and early infection were associated risk of developing AL in children DS. Children DS Mexico City, either or without AL, cases (N=57) controls (N=218), respectively. Population was divided lymphoblastic (ALL) ⩽6 >6 years old. Breastfeeding infections showed moderate (but...
Abstract BACKGROUND: The incidence of unilateral retinoblastoma varies globally, suggesting possible environmental contributors to disease incidence. Maternal intake naturally occurring folate from vegetables during pregnancy is associated inversely with the risk in offspring. METHODS: authors used a case‐control study design examine association between and maternal variations folate‐metabolizing genes methylenetetrahydrofolate reductase ( MTHFR ) (a cytosine‐to‐thymine substitution at...
Mexico has one of the highest incidences childhood leukemia worldwide and significantly higher mortality rates for this disease compared with other countries. One possible cause is high prevalence gene rearrangements associated etiology or a poor prognosis acute lymphoblastic (ALL). The aims multicenter study were to determine four most common [ ETV6-RUNX1, TCF3-PBX1, BCR-ABL1 , MLL rearrangements] explore their relationship during first year treatment in ALL children from City. Patients...
The role of malnutrition at diagnosis as a predictor early mortality in Mexican leukemia children remains controversial. objective present study was to investigate whether during the first year treatment acute lymphoblastic (ALL) through population-based study. A total 794 newly diagnosed ALL pediatric patients from public hospitals Mexico City were enrolled. multivariate Cox proportional hazards regression model constructed and adjusted by patient's age diagnosis, gender, hospital...
Mexico City has one of the highest incidences and mortality rates acute lymphoblastic leukemia (ALL) in world a high frequency early relapses (17%) (15%). Otherwise, childhood overweight obesity are reaching epidemic proportions. They have been associated with poor outcomes children ALL. The aim present study was to identify if predictors relapse Mexican ALL.A multicenter cohort conducted. ALL younger than 15 years old were included followed-up during first 24 months after diagnosis....
Genetic polymorphisms in patients with acute lymphoblastic leukemia (ALL) may influence the toxicity of chemotherapeutic agents. Due to importance transport P-glycoprotein and methylenetetrahydrofolate reductase metabolism agents, we analyzed MDR1 rs1045642 MTHFR rs1801133 their associations clinical outcomes Mexican childhood ALL patients.A total 109 participated this study. The evaluation consisted a physical examination laboratory test. Genotyping (3435 C>T) (677 was performed by...
Abstract Background Medical research has not been able to establish whether a father's occupational exposures are associated with the development of acute leukemia (AL) in their offspring. The studies conducted have weaknesses that generated misclassification such exposure. Occupations and substances childhood cancer very frequently encountered general population; thus, reported risks both inconsistent inaccurate. In this study, assess exposure we used new method, an index, which took into...
Evidence showing the role of long non-coding RNAs (lncRNAs) in leukemogenesis have emerged last decade. It has been proposed that these genes can be used as diagnosis and/or prognosis biomarkers childhood acute lymphoblastic leukemia (ALL). To know if lncRNAs are associated with early relapse and mortality, a microarray-based gene expression analysis children B-lineage ALL (B-ALL) was conducted. Cox regression analyses were performed. Hazard ratios (HR) 95% confidence intervals (95% CI)...
Acute lymphoblastic leukemia (ALL) is the most common cancer in children around globe. Mexico City has one of highest incidence rates childhood worldwide with 49.5 cases per million under age 15 which similar to that reported for Hispanic populations living United States. In addition, it been noted a dismal prognosis Mexican and ALL pediatric population. Although ALL, like general, its origins endogenous, exogenous, genetic factors, several studies have shown immune system also plays...
Introduction Acute leukemias (AL) are the main types of cancer in children worldwide. In Mexico, they represent one causes death under 20 years age. Most studies on incidence AL Mexico have been developed urban context Greater City and no previous conducted central-south country through a population-based study. The aim present work was to identify general specific rates pediatric three states south-central region considered as some marginalized populations (Puebla, Tlaxcala, Oaxaca)....
Background: The few epidemiologic studies of infection exposure in early life and acute leukemia (AL) risk Latino children have yielded inconsistent results, suggesting a possible effect ethnicity. Here, we examined the correlation between from Mexico City—One biggest cities worldwide. Methods: This study included 1455 Mexican diagnosed with de novo AL (2002–2016), control individuals frequency-matched by age health institution. population lymphoblastic (ALL), Pre-B ALL, myeloblastic (AML)....
Introduction Over the years, Hispanic population living in United States has consistently shown high incidence rates of childhood acute leukemias (AL). Similarly, AL was previously observed Mexico City (MC). Here, we estimated among children under 15 years age MC during period 2010–2017. Methods The Mexican Interinstitutional Group for Identification Causes Childhood Leukemia conducted a study gathering clinical and epidemiological information regarding newly diagnosed with at public health...
Allergies have been described as protective factors against the development of childhood acute leukaemia (AL). Our objective was to investigate associations between allergy history and AL lymphoblastic (ALL) in children with Down syndrome (DS). A case–control study performed Mexico City. The cases (n=97) were diagnosed at nine public hospitals, controls (n=222) recruited institutions for DS. Odds ratios (OR) calculated. Asthma positively associated (OR=4.18; 95% confidence interval (CI):...
Background: Acute Myeloid Leukemia is the second most frequent leukemia in childhood. The FLT3 gene participates hematopoietic stem cell proliferation. mutations are recurrent AML and influence prognosis. In Mexican pediatric patients, mutational profile their clinical impact have not been evaluated. Aim of study. Identify patients with de novo assess possible on overall survival (OS) other features. Methods: Massive parallel target sequencing was performed 80 patients. Results: (ITD or TKD)...
Cancer is the second most common cause of death among children aged 1-14 years. Leukemia accounts for one-third all childhood cancers, 78% which acute lymphoblastic leukemia (ALL). The development cancer has been associated with malignant cells that express low levels immunogenic molecules, facilitates their escape from antineoplastic immune response. It thought it may be possible to rescue response through activation recognition receptors, such as Toll-like receptors (TLRs), activate innate...
Acute lymphoblastic leukemia is the most common type of childhood cancer worldwide. Mexico City has one highest incidences and mortality rates this cancer. It previously been recognized that chromosomal translocations are important in etiology. Specific fusion genes have considered as treatment targets acute (ALL). The present research aimed at identification characterization novel with potential clinical implications Mexican children leukemia. RNA-sequencing approach was used. Four not...