Background: Several methods have been investigated recently to improve the solubility and bioavailability. Inclusion complex approach is a potential way for enhancing solubility. Aim of study: It could be said drug atorvastatin which has poor aqueous by making inclusion with water soluble compound Sulfobutylether-β-Cyclodextrin its Methods: complexes Sulfobutylether-β Cyclodextrin were formulated using kneading method one ratio one, two, three, four five. The studies phase tests unveil that...

Objective:To evaluate the efficacy and safety of atorvastatin + hydroxychloroquine fixed-dose combination tablets in comparison with alone treatment dyslipidemia.Methods:This double-blind, randomized, out-patient study was conducted 328 patients primary dyslipidemia having low-density lipoprotein cholesterol (LDL-C) ≥130 mg/dL (3.37 mmol/L) to ≤250 (6.48 triglycerides ≤400 (4.52 mmol/L). Eligible were randomized receive either 10 mg (n = 167) or 200 161) for 24 weeks.Clinical trial...

Polymorphic light eruption is the most common photodermatosis characterized by nonscarring, pruritic, erythematous papules and plaques.To evaluate efficacy safety of hydroxychloroquine in comparison with chloroquine patients suffering from polymorphic eruption.This was a randomized, double-blind, comparative, multicentric study conducted at two centers. This enrolled 68 (58.1%) males, 49 (41.8%) females whose ages ranged 18-73 years average weight 57.89 +/- 8.27 kg. A total 117 were study....

Objective: Hydroxychloroquine (HCQ) has been used for a long time worldwide as therapy rheumatoid arthritis (RA). This trial was designed to determine whether HCQ efficacious and safe in Indian patients with RA.Research design methods: The multicentre, placebo controlled, randomized double-blind study. One hundred twenty-two RA were enrolled 3 different centres the (26 males 96 females age group of 18–60 years). Patients receive either hydroxychloroquine tablets (n = 61) two 200 mg daily or...

Objective: The relationship of blood pressure (BP) to cardiovascular risk is linear, positive, and continuous. Lowering elevated BP reduces the events. primary objective this randomized, multicenter, comparative, 3-month, open-label study was evaluate antihypertensive efficacy losartan/chlorthalidone versus losartan/hydrochlorothiazide in mild-to-moderate essential hypertension. Methods: A total 137 eligible patients underwent a 2-week placebo washout period, following which 131 were...

To evaluate the efficacy and safety of etodolac-paracetamol combination in comparison with etodolac alone patients knee osteoarthritis (OA) flare-up.In this double-blind, double-dummy, randomized, comparative, multicentric, parallel group study, 220 either sex age range 40 to 70 years an OA flare-up were randomized (300 mg)-paracetamol (500 mg) or twice a day for 10 days. Efficacy outcomes average daily pain intensity score on 11-point visual analog scale, Western Ontario McMaster (WOMAC),...

<b>Objective:</b> To evaluate the antihyperglycemic activity of atorvastatin and hydroxychloroquine combination in alloxan-induced diabetic rats.<br><b> Materials Methods:</b> Alloxan induced Wistar male rats were randomized into six groups 6 each. (Normal rats, control, (ATV), (HCQ), ATV 5 mg /kg + HCQ 100 mg/kg, 10 mg/kg 200 mg/kg). The treated for 9 days blood samples collected at baseline end therapy. These analyzed plasma glucose by autoanalyzer. Changes body weight, water, food intakes...

Thiazolidinediones (TZDs) are insulin sensitizers used for treatment of diabetes. We have previously reported that TZDs reduce estrogen synthesis by inhibiting aromatase activity in human granulosa cells (HGC). Multiple clinical trials demonstrated increase the risk fractures postmenopausal women with type 2 studied mouse osteoblasts alone or a co-culture HGC to determine whether TZD inhibition plays role their effects on bone metabolism. Mouse were cultured and without HGC, incubated medium...

Objective: To compare the efficacy and safety of low-dose chlorthalidone + atenolol combination with amlodipine in stage I hypertensive patients uncontrolled on active run-in monotherapy.Methods: Newly diagnosed were randomized to monotherapy either 25 mg (98/300) or 6.25 (100/300) 2.5 (102/300). A total 282/300 (atenolol 92, 91, 99) completed phase successfully. Patients 33, 45, 47) received study treatment, namely 50 alone, mg, respectively. Efficacy therapy was evaluated by BP measurement...

Objective: To demonstrate the clinical noninferiority of analgesic effect zaltoprofen (80 mg t.i.d.) compared with diclofenac (50 in active knee osteoarthritis patients. Method: In this multicentric, double-blind, double-dummy, randomized, parallel-group, comparative study, 213 patients either sex, aged 40 – 65 years having radiological and clinically confirmed primary were randomized to (n = 105) or 108) followed-up at weeks 1, 2, 3 4. The treatment period was preceded by a washout 1 week....

Abstract Objective To establish efficacy and safety of artesunate/lumefantrine fixed‐dose combination ( FDC ) in comparison with artemether/lumefantrine treatment uncomplicated P lasmodium falciparum malaria. Methods Confirmed cases . malaria were randomly assigned to receive artesunate (100 mg)/lumefantrine (480 mg) ASLF or artemether (80 AMLF tablets for 3 days. Patients followed up on Day 7, 14, 21 28. Results Of the 158 enrolled patients, 144 completed study. Seventy‐three patients...

Abstract Hydroxychloroquine, an antimalarial agent has also been found to possess antidiabetic action. Onset of type-2 diabetes (T2DM) and cardiovascular disease is now considered be the outcome systemic inflammation. Many clinical trials are targeting inflammation reduce risk. Anti-inflammatory drugs with effects may valuable therapeutic intervention massive risk in T2DM. In this review, action potential cardioprotective role hydroxychloroquine discussed. By virtue its antidiabetic, lipid...

We have read the study design “Comparison of effects between calcium channel blocker and diuretics in combination with angiotensin II receptor on 24-h central blood pressure vascular hemodynamic parameters hypertensive patients: for a multicenter, double-blinded, active controlled, phase 4, randomized trial” by Oh GC, et al. interest. The authors aim to compare efficacy amlodipine or hydrochlorothiazide (HCTZ) an ARB. However, we wish highlight that chlorthalidone (CTD) is evidence-based...

Objective: Many T2D patients have inadequate glycemic control despite conventional therapy of dual OHAs. Treating such in developing countries is a challenge as newer drugs are comparatively costly or may apprehensions for injectable insulin. Objective this observational study was to evaluate effectiveness add-on HCQ these patients. Methods: A prospective, observational, multi-centre conducted where 1,007 (age between 18-65 years), uncontrolled on combination two OHAs, with HbA1c ≥7.5%,...

Osteoarthritis (OA) is the most common form of arthritis, affecting millions people worldwide.It an inflammatory, degenerative and progressive disease which worsens over time, resulting in joint pain, swelling stiffness.As progresses, pain stiffness become severe making daily tasks difficult, thereby quality life.The treatment osteoarthritis mainly focuses on management inflammation to control symptoms as complete reversal not practical.Non-steroidal anti-inflammatory drugs (NSAIDs) are...

Hydroxychloroquine, due to its multifaceted pleiotropic benefits including anti-inflammatory effects has great potential in reducing cardiovascular (CV) morbidity and mortality. CV outcome data of hydroxychloroquine is available through 2 retrospective studies rheumatoid arthritis patients, both which have not considered congestive heart failure (CHF) as an measure. CHF important more common than myocardial infarction stroke; increased age associated with risk CHF. Hydroxychloroquine...

Prostate carcinoma is a highly prevalent biologically and clinically heterogeneous disease. Unfortunately, within 5 years of diagnosis, 10-20% patients acquire castration-resistant prostate cancer (CRPC) in spite multiple surgical non-surgical therapy choices. The clinical context CRPC heterogeneous, encompassing with asymptomatic prostate-specific antigen (PSA) elevation following ADT failure good performance status, as well those experiencing severe, incapacitating symptoms rapidly...