A5027852280- Mathematical and Theoretical Epidemiology and Ecology Models
- Mosquito-borne diseases and control
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Nanoplatforms for cancer theranostics
- Viral Infections and Vectors
- COVID-19 epidemiological studies
- Acute Ischemic Stroke Management
- Evolution and Genetic Dynamics
- Liver Disease Diagnosis and Treatment
- Organometallic Complex Synthesis and Catalysis
- Carbohydrate Chemistry and Synthesis
- COVID-19 Clinical Research Studies
- Malaria Research and Control
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Evolutionary Game Theory and Cooperation
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Heavy metals in environment
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Cancer Mechanisms and Therapy
- Nonlinear Dynamics and Pattern Formation
- Intracerebral and Subarachnoid Hemorrhage Research
University of Minnesota
2024-2025
Twin Cities Orthopedics
2025
Washington University in St. Louis
2016-2024
R. G. Kar Medical College and Hospital
2015-2024
University of Minnesota System
2023-2024
Trinity Washington University
2024
The University of Texas Southwestern Medical Center
2024
Southwestern Medical Center
2024
Medical College and Hospital, Kolkata
2022-2024
College of Medicine & Sagore Dutta Hospital
2023-2024
The host cell serine protease TMPRSS2 is an attractive therapeutic target for COVID-19 drug discovery. This activates the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses essential viral spread in lung. Utilizing rational structure-based design (SBDD) coupled to substrate specificity screening TMPRSS2, we have discovered covalent small-molecule ketobenzothiazole (kbt) inhibitors which are structurally distinct from significantly improved...
Tumor-infiltrating myeloid cells contribute to the development of immunosuppressive tumor microenvironment. Myeloid cell expression arginase 1 (ARG1) promotes a protumor phenotype by inhibiting T function and depleting extracellular l-arginine, but mechanism underlying this expression, especially in breast cancer, is poorly understood. In cancer clinical samples our mouse models, we identified tumor-derived GM-CSF as primary regulator ARG1 local immune suppression through gene-KO screen...
Abstract Most cancer patients succumb to disseminated disease because conventional systemic therapies lack spatiotemporal control of their toxic effects in vivo, particularly a complicated milieu such as bone marrow where progenitor stem cells reside. Here, we demonstrate the treatment by photoactivatable drugs using radiopharmaceuticals. An orthogonal-targeting strategy and contact-facilitated nanomicelle technology enabled highly selective delivery co-localization titanocene radiolabelled...
Bankura district has long cultural heritage in making of beautiful and world-famous handicrafts. Terracotta, Dokra, Stone Curving, Wood Weaving is few examples among them. But besides these well-known handicrafts, ‘Singing Bowl’ remains unsung to everybody. It an outstanding handicraft alloy at various places this the state West Bengal. This bowl can have made from bell brass metal. In past, bowls were use worships God, for holistic rituals, domestic use. presently using medical sound...
Ti-catalyzed alkyne diamination and hydrohydrazination proceed through a common N-aminoazatitanacyclobutene intermediate. These reactions have historically existed as processes catalyzed by distinct molecular Ti compounds, with several reports for only single example diamination. Here, we demonstrate that diamidoamine catalyst, (NNN)Ti(═NNR2) (1, (NNN)H2 = N-methyl-N',N″-bis(trimethylsilyl)diethylenetriamine; R alkyl, aryl), is capable of catalyzing both hydrohydrazination, where the...
Generation of a CD8(+) response to extracellular antigen requires processing the by presenting cells (APC) and cross-presentation T cell receptors via MHC class I molecules. Cross-presentation is facilitated efficient uptake followed immune-complex-mediated maturation APCs. We hypothesize that improved glycopeptide sequence containing epitope could be achieved delivering it on liposome surface decorated with an immune complex-targeting ligand, l-Rhamnose (Rha) epitope. synthesized...
Utilizing natural antibodies to augment vaccine immunogenicity is a promising approach toward cancer immunotherapy. Anti-rhamnose (anti-Rha) are some of the most common anti-carbohydrate present in human serum. Therefore, rhamnose can be utilized as targeting moiety for rhamnose-containing prepare an effective formulation. It was shown previously that anti-Rha antibody generated mice binds effectively with Rha-conjugated and picked up by antigen presenting cells (APCs) through stimulatory Fc...
Abstract Upregulation of the HGF and MSP growth‐factor processing serine endopeptidases HGFA, matriptase hepsin is correlated with increased metastasis in multiple tumor types driven by c‐MET or RON kinase signaling. We rationally designed P1’ α‐ketobenzothiazole mechanism‐based inhibitors these proteases. Structure–activity studies are presented, which resulted identification potent differential selectivity. The tetrapeptide span P1–P1’ substrate cleavage site via a amide linker off...
Terminal imido complexes containing metal–nitrogen multiple bonds have been widely used in organometallic chemistry and homogeneous catalysis. The role of terminal ligands spans from reactive sites to spectator motifs, largely depending on the nature metal center its specific coordination sphere. Aiming at identifying reactivity descriptors for M–N bonds, we herein explore solid-state 15N NMR spectroscopy (ssNMR) early transition augmented by computational studies show that asymmetry...
Background and purpose Stroke‐associated early seizures ( ES ) often complicate the initial course of acute stroke. This study intended to estimate rate predictive factors for impact on clinical outcome in patients with first‐ever Materials methods Consecutive stroke admitted D epartment M edicine from J une 2010 ecember 2011 were prospectively included. defined as occurring within 7 days Patients history epilepsy, transient ischaemic attack, subarachnoid haemorrhage cerebral venous...
Dengue, a mosquito-borne disease caused by flavivirus, is recognized in over 120 countries with 3.6 billion people living areas at risk. Neurological manifestations are infrequently reported as clinical consequences of dengue infection. Though severe may be associated meningoencephalitis, meningitis rare initial presentation otherwise uncomplicated fever. We report two adult patients who presented fever, headache, and nuchal rigidity without the typical symptoms Cerebrospinal fluid (CSF)...
Matriptase and hepsin belong to the family of type II transmembrane serine proteases (TTSPs). Increased activity these plasma protease, hepatocyte growth factor activator (HGFA), is associated with unregulated cell signaling tumor progression through increased MET RON kinase pathways. These are highly expressed in multiple solid tumors hematological malignancies. Herein, we detail synthesis structure–activity relationships (SAR) a dipeptide library bearing Arg α-ketobenozothiazole (kbt)...
Terminal imido complexes, containing metal-nitrogen multiple bonds, have been widely used in organometallic chemistry and homogeneous catalysis. The role of terminal ligands span from reactive site to spectator motif, largely depending on the nature metal center its specific coordination sphere. Aiming at identifying reactivity descriptors for M-N we herein explore solid-state 15N NMR spectroscopy (ssNMR) early-transition complexes augmented by computational studies show that asymmetry...
There exists several natural instances in which systems may undergo through local degradation of its constituting elements. This severely affect the overall dynamical activity unexpected ways. So, it requires to overcome such situations while posing some appropriate mechanisms. In this work we investigate aging networks comprising different groups units coupled locally, non-locally or globally. We provide a mechanism that deals with asymmetry interaction active and inactive enhance...
Abstract Interactions of light-sensitive drugs and materials with Cerenkov radiation-emitting radiopharmaceuticals generate cytotoxic reactive oxygen species (ROS) to inhibit localized disseminated cancer progression, but the cell death mechanisms underlying this radionuclide stimulated dynamic therapy (RaST) remain elusive. Using ROS-regenerative nanophotosensitizers coated a tumor-targeting transferrin-titanocene complex (TiO2-TC-Tf) radiolabeled 2-fluorodeoxyglucose (18FDG), we found that...
A strategy for the solid phase peptide synthesis (SPPS) and coupling of N-peptidyl N-glycopeptidyl 2,4-dinitrobenzenesulfonamides (dNBS) with C-terminal peptidyl thioacids has been developed. The resulting N-dDNBS peptides were coupled to generate longer peptides. Ligation reactions complete within 15 20 min.
Background Conjugation of transferrin (Tf) to imaging or nanotherapeutic agents is a promising strategy target breast cancer. Since the efficacy these biomaterials often depends on overexpression targeted receptor, we set out survey expression receptor (TfR) in primary and metastatic cancer samples, including metastases relapse, investigate its modulation experimental models. Methods Gene was investigated by datamining twelve publicly-available datasets. Dedicated Tissue microarrays (TMAs)...
Mycobacterium tuberculosis infection is a common in developing countries, including India. It can induce several cutaneous reactions such as erythema nodosum, and induratum; however, association of with Sweet’s syndrome (also known acute febrile neutrophilic dermatosis) extremely rare. Here we present an interesting case sputum-positive pulmonary syndrome. A 55-year-old female who was receiving regimen four antitubercular drugs (isoniazid, rifampicin, pyrazinamide, ethambutol- HRZE) for six...