A5072181077- Plant Stress Responses and Tolerance
- Plant nutrient uptake and metabolism
- Protein Kinase Regulation and GTPase Signaling
- Legume Nitrogen Fixing Symbiosis
- Biochemical and Molecular Research
- Hepatitis B Virus Studies
- Plant tissue culture and regeneration
- Plant Molecular Biology Research
- Greenhouse Technology and Climate Control
- Photosynthetic Processes and Mechanisms
- Phagocytosis and Immune Regulation
- Liver physiology and pathology
Washington University in St. Louis
2018-2024
University of California, Riverside
2015-2019
Plant thirst quenched without water Drought causes many billions of dollars annual losses to farmers worldwide. Central a plant's use efficiency are signaling pathways regulated by the hormone abscisic acid and its receptors. Vaidya et al. screened pool candidate small molecules used structure-guided design optimize function an receptor agonist (see Perspective Phillips Sussman). Application protected Arabidopsis , wheat, tomato from underwatering. Science this issue p. eaaw8848 ; see also 416
Increasing drought and diminishing freshwater supplies have stimulated interest in developing small molecules that can be used to control transpiration. Receptors for the plant hormone abscisic acid (ABA) emerged as key targets this application, because ABA controls apertures of stomata, which turn regulate Here, we describe rational design cyanabactin, an receptor agonist preferentially activates Pyrabactin Resistance 1 (PYR1) with low nanomolar potency. A 1.63 Å X-ray crystallographic...
Abstract Inhibition of the proteolytic processing hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP) is an attractive approach for drug discovery novel anticancer therapeutics which prevent tumor progression metastasis. Here, we utilized improved expanded version positional scanning substrate combinatorial libraries (PS‐SCL) technique called HyCoSuL to optimize peptidomimetic inhibitors HGF/MSP activating serine proteases, HGFA, matriptase, hepsin. These have...
Matriptase and hepsin belong to the family of type II transmembrane serine proteases (TTSPs). Increased activity these plasma protease, hepatocyte growth factor activator (HGFA), is associated with unregulated cell signaling tumor progression through increased MET RON kinase pathways. These are highly expressed in multiple solid tumors hematological malignancies. Herein, we detail synthesis structure–activity relationships (SAR) a dipeptide library bearing Arg α-ketobenozothiazole (kbt)...