A5058413340- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- RNA Interference and Gene Delivery
- Glaucoma and retinal disorders
- Proteoglycans and glycosaminoglycans research
- Virus-based gene therapy research
- Fibroblast Growth Factor Research
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- TGF-β signaling in diseases
- Pesticide Exposure and Toxicity
- Protease and Inhibitor Mechanisms
- NF-κB Signaling Pathways
- Advanced Glycation End Products research
- Histone Deacetylase Inhibitors Research
- Retinoids in leukemia and cellular processes
- Cell Adhesion Molecules Research
- Connective Tissue Growth Factor Research
- Sulfur Compounds in Biology
- Liver physiology and pathology
- Retinopathy of Prematurity Studies
- Wound Healing and Treatments
- Platelet Disorders and Treatments
Harry S. Truman Memorial Veterans' Hospital
2016-2025
University of Missouri
2016-2025
Missouri College
2016-2025
Cincinnati Eye Institute
2010-2024
University of Missouri Health System
2015-2024
Memorial Hospital
2010-2021
JSS Medical College and Hospital
2020
Columbia University
2019
Royal Manchester Children's Hospital
2018
University of Missouri Hospital
2010-2017
To determine the mechanism through which topical mitomycin C prevents and treats corneal haze after photorefractive keratectomy (PRK) to examine effects of dosage duration exposure.In 224 New Zealand rabbits, -9.0 diopter PRK with or balanced salt solution was performed. Haze level graded at slit-lamp. Rabbits were sacrificed 4 hours, 24 weeks, 6 months surgery immunohistochemistry performed TUNEL assay, Ki67, alpha-SMA.TUNEL-positive apoptotic cells marginally increased in all groups...
ABSTRACT PURPOSE: To examine early postoperative wound healing in rabbit corneas that had LASIK flaps formed with three different models (15 KHz, 30 KhZ, and 60 KHz) of a femtosecond laser compared microkeratome. METHODS: Thirty-nine eyes were randomized to receive either no surgery or corneal one the lasers Sixteen also lamellar cuts side KHz laser. Animals sacrificed processed as frozen sections fixed for transmission electron microscopy. Frozen evaluated TUNEL assay detect apoptosis,...
Diabetic retinopathy (DR) is a retinal microvascular disease characterized by inflammatory and angiogenic pathways. In this study, we evaluated NLRP3 inflammasome in double transgenic mouse model, Akimba (Ins2
Abstract Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation substrate compliance live tissues has not been accomplished to date. Here we propose that stem cells can be regulated solely through situ tissue biomechanics. By first establishing, high-resolution Brillouin spectro-microscopy, outer edge (limbus) human corneas a substantially lower bulk modulus compared their centre, then demonstrate this difference is associated with limbal epithelial (LESC)...
This study examined the effects of BMP7 gene transfer on corneal wound healing and fibrosis inhibition in vivo using a rabbit model. Corneal haze rabbits was produced with excimer laser performing -9 diopters photorefractive keratectomy. introduced into keratocytes by polyethylimine-conjugated gold nanoparticles (PEI2-GNPs) transfection solution single 5-minute topical application eye. ocular health live animals gauged stereo- slit-lamp biomicroscopy. The levels [α-smooth muscle actin...
In this study, we elucidated the differential expression of a set local molecular factors in ectatic cone area cornea to uncover functional cause for focal corneal weakening characteristic keratoconus (KC) disease.All human samples were collected after approval Institutional Ethics Committee and informed consent. Keratoconus patients classified based on clinical parameters, topographical features, structural deformity. Epithelial cells from KC (n = 66) undergoing cross-linking procedures...
Decorin, small leucine-rich proteoglycan, has been shown to modulate angiogenesis in nonocular tissues. This study tested a hypothesis that tissue-selective targeted decorin gene therapy delivered the rabbit stroma with adeno-associated virus serotype 5 (AAV5) impedes corneal neovascularization (CNV) vivo without significant side effects. An established CNV model was used. Targeted single topical AAV5 titer (100 µl; 5×10(12) vg/ml) application onto for two minutes after removing epithelium....