A5088519231- Prostate Cancer Treatment and Research
- Radiopharmaceutical Chemistry and Applications
- Cancer, Lipids, and Metabolism
- Herpesvirus Infections and Treatments
- Alzheimer's disease research and treatments
- Virology and Viral Diseases
- Polyomavirus and related diseases
- Dental Education, Practice, Research
- Prostate Cancer Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Bacterial biofilms and quorum sensing
- Acne and Rosacea Treatments and Effects
- Artificial Intelligence in Healthcare and Education
- Bacterial Identification and Susceptibility Testing
- Complement system in diseases
- Thermal Regulation in Medicine
- Renal Diseases and Glomerulopathies
- Neonatal and Maternal Infections
- Antimicrobial Resistance in Staphylococcus
- Lipid Membrane Structure and Behavior
- Dental Health and Care Utilization
- Immune responses and vaccinations
- Pharmacological Receptor Mechanisms and Effects
- Immune Cell Function and Interaction
- COVID-19 epidemiological studies
UNSW Sydney
2024-2025
The University of Queensland
2022-2025
St Vincent's Clinic
2024-2025
St Vincent's Hospital Sydney
2024-2025
La Jolla Bioengineering Institute
2024
University of California, San Diego
2024
Queensland Health
2019-2023
Toowoomba Hospital
2019-2023
Cairns Hospital
2022
George Washington University
2022
Abstract Amyloid β (Aβ) ion channels destabilize cellular ionic homeostasis, which contributes to neurotoxicity in Alzheimer’s disease. The relative roles of various Aβ isoforms are poorly understood. We use bilayer electrophysiology, AFM imaging, circular dichroism, FTIR and fluorescence spectroscopy characterize channel activities four most prevalent peptides, 1-42 , 1-40 their pyroglutamylated forms (AβpE 3-42 AβpE 3-40 ) correlate them with the peptides’ structural features....
17 Background: Interim analysis of ENZA-p with median follow-up 20 months showed improved PSA-progression-free survival (PFS) and depth PSA-response the addition [ 177 Lu]Lu-PSMA-617 (LuPSMA) to enzalutamide (enza) as first-line treatment poor-risk, metastatic, castration-resistant prostate cancer (mCRPC). Here we report effects on overall (OS) health-related quality life (HRQL) longer follow-up. Methods: We randomly assigned 162 participants (pts) enza 160 mg daily alone, or in combination...
Introduction Pembrolizumab is a humanised monoclonal antibody targeting the receptor programmed cell death protein-1 (PD-1), with anti-tumour activity demonstrated for many malignancies. Such immune checkpoint inhibitors are associated immune-related adverse events including rash, colitis, hepatitis, pneumonitis, endocrinopathy and, rarely, haematological events, thrombocytopenia. Case report We 60-year-old female metastatic non-small lung cancer treated pembrolizumab every three weeks....
To determine if shorter courses of antibiotic therapy for group A Streptococcus (GAS) bacteremia are associated with excess mortality.In this retrospective study consecutive cases GAS in tropical Australia, the duration was correlated 90-day all-cause mortality.There were 286 episodes bacteremia; patients' median (interquartile range) age 60 (48-71) years and 169/286 (59.1%) patients identified as an Indigenous Australian. There 227/286 (79.4%) a significant comorbidity. The mortality 16/286...
Staphylococcus schleiferi bacteremia is an underappreciated cause of septic shock in the critical care department. Although nominally a coagulase variable and associated with otitis externa infections canine species, it has been metastatic infection including osteomyelitis, endocarditis, nephritis, meningitis humans. This report records possible zoonotic case S . subspecies coagulans following endovascular precipitating intensive admission for vasopressor support immunocompetent male.
Consider the differential of Epstein-Barr virus (EBV) reactivation in pregnant women who develop progressive meningoencephalitis and transverse myelitis. EBV nucleic acid amplification should be considered immunosuppressed patients.
[<sup>177</sup>Lu]Lu-prostate-specific membrane antigen (PSMA) is an effective treatment for metastatic castration-resistant prostate cancer (mCRPC). [<sup>177</sup>Lu]Lu-PSMA SPECT/CT 24 h after injection has shown potential as a response biomarker therapy but not convenient patients. This study investigated 4-h alternative to 24-h evaluation of response. <b>Methods:</b> prospective analysis enrolled 23 patients diagnosed with mCRPC commencing [<sup>177</sup>Lu]Lu-PSMA-I&T therapy. Two...
Introduction Over the past two decades, Asia has experienced rise and integration of Western medicine digital health in its field medicine. In this study, we investigated trends orthopaedic publications from three Asian countries: China, Japan, Korea. Methods PubMed was used to measure number Korea 21 years, 1998 2020. The average percentage change during 21-year time period analyzed using descriptive statistics. annual each country also determined. One-way analysis variance two-group...
ObjectiveTo evaluate whether dried blood spot (DBS) testing improves diagnostic uptake in Vientiane Capital City province, Lao People's Democratic Republic (PDR) compared to conventional techniques (venous by venepuncture) during syndromic surveillance from 2016-17. To also explore reasons for low sampling via quantitative results and qualitative responses health care workers; addition the perceived acceptance of DBS venepuncture.IntroductionThe PDR is aiming measles elimination despite...