Objective We tested the hypothesis that first‐trimester metabolic biomarkers offered a unique profile in women with preeclampsia (PE) second half of pregnancy, compared controls. Method conducted nested case‐control study within prospective cohort pregnant followed from to delivery. Cases were those who developed PE at any gestational age, and these control group without adverse pregnancy outcome, matched for age 3 days. analyzed maternal blood obtained 11–14 weeks' gestation 40...

Objective This study aims to determine if advanced maternal age (AMA) is a risk factor for major congenital anomalies, in the absence of aneuploidy. Study Design Retrospective cohort all patients with singleton gestation presenting second trimester anatomic survey over 19-year period. Aneuploid fetuses were excluded. groups defined by ≤ 34 and ≥ 35 years. The primary outcome was presence one or more anomalies diagnosed at ultrasound. Univariable multivariable logistic regression analyses...

Abstract Objective To determine if a simplified model for predicting pre‐eclampsia (PEC) can be developed by combining first‐trimester serum analytes, pregnancy‐associated plasma protein A (PAPP‐A) and free beta human chorionic gonadotrophin (β‐hCG), maternal characteristics. Methods retrospective cohort study of patients seen aneuploidy screening from 2003 to 2009. The 5th, 10th, 90th, 95th percentiles the analyte multiples medians (MoMs) our population were determined evaluated association...

To estimate if echogenic bowel diagnosed on second-trimester ultrasonography has an independent risk association with intrauterine growth restriction (IUGR) and fetal demise.This is a retrospective cohort study of all patients singleton gestations who presented to our institution for between 1990 2008. Study groups were defined by the presence or absence bowel. Primary outcomes IUGR, as birth weight less than 10th percentile gestational age demise at 20 weeks more gestation. Univariable...

To estimate the association between antenatal bowel dilation and postnatal small-bowel atresia in fetal gastroschisis to establish a threshold at which risk of adverse neonatal outcome increases.This was retrospective cohort study singleton gestations with an diagnosis seen our ultrasound unit from 2001 2010. We reviewed stored images last examination before delivery, blinded diagnoses outcomes. Fetal intra- extra-abdominal (IABD EABD, respectively) bowel-wall thickness were measured....

To estimate the effect of early administration aspirin on prevention pre-eclampsia in high-risk women.This was planned as a randomized, double-blind, placebo-controlled trial for women with risk factors pre-eclampsia. Participants were randomized to start either (81 mg/day) or placebo at 11 + 0 13 6 weeks gestation. The primary outcome and secondary outcomes included gestational hypertension small-for-gestational age birth.The suffered from slow recruitment, leading protocol change broaden...

To determine the association of, and predictive ability pregnancy-associated plasma protein A (PAPP-A), free beta-human chorionic gonadotrophin (beta-hCG), nuchal translucency (NT) with preterm birth (PTB).A 5-year retrospective cohort study of women who underwent first-trimester combined screening was performed. Maternal medical, antepartum, pregnancy outcome data were obtained. PAPP-A beta-hCG converted to multiples median (MoM), primary exposure defined as < or =10th percentile MoM for...

Customized growth charts developed for singleton pregnancies have been shown to be more effective than population-based ones at identifying small-for-gestational age (SGA) fetuses risk intrauterine fetal death (IUFD). We sought compare the association between SGA and IUFD in twins using customized designed twin gestations compared those singletons.This was a retrospective cohort study database including undergoing ultrasound examination 16 20 weeks' gestation. After excluding preterm births...

Objectives To estimate the association between isolated second-trimester short femur length and fetal growth restriction as well other adverse perinatal outcomes. Methods We conducted a retrospective cohort study of patients with singleton gestations presenting for sonography 16 24 weeks' gestation from 1990 to 2009. Cases aneuploidy, skeletal dysplasia, major anomalies were excluded. Short was defined below 10th percentile gestational age considered when both estimated weight abdominal...

To evaluate whether clinical characteristics alter the accuracy of estimation fetal weight (EFW) in term pregnancies a teaching hospital.Secondary analysis retrospective cohort study patients presenting for labor at term. Clinical EFW was performed using Leopold maneuvers. A Spearman's rank correlation coefficient (r) used to linear relationship between and actual birth (BW). Body mass index (BMI), gestational age, station, admission diagnosis were evaluated with respect their impact on EFW....

<b>Objective</b> The aim of this study was to develop a multiparameter risk-based scoring system for first-trimester prediction preeclampsia and validate in our patient population. <b>Study Design</b> Secondary analysis prospective cohort 1,200 patients presenting aneuploidy screening. Maternal serum pregnancy-associated plasma protein A (PAPP-A) levels were measured bilateral uterine artery (UA) Doppler studies performed. Using the first half population, model created. Test performance...

The purpose of this study was to estimate the efficiency first-trimester uterine artery Doppler, A-disintegrin and metalloprotease 12 (ADAM12), pregnancy-associated plasma protein A (PAPP-A), maternal characteristics in prediction preeclampsia.We conducted a prospective cohort patients presenting for aneuploidy screening between 11 14 weeks' gestation. Maternal serum ADAM12 PAPP-A levels were measured by an immunoassay, mean Doppler pulsatility indices calculated. Outcomes interest included...

ABSTRACT Objective The objective of this study was to estimate the efficiency first‐trimester a disintegrin and metalloprotease 12 (ADAM12), pregnancy‐associated plasma protein A (PAPP‐A), uterine artery Doppler, maternal characteristics in prediction preterm birth (PTB). Methods This prospective cohort patients presenting for aneuploidy screening. Maternal serum ADAM12 PAPP‐A levels were measured by immunoassay, mean Doppler pulsatility indices calculated. primary outcome PTB &lt;34 weeks'...