A5056024643- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- bioluminescence and chemiluminescence research
- SARS-CoV-2 and COVID-19 Research
- Receptor Mechanisms and Signaling
- Retinal Development and Disorders
- Respiratory viral infections research
- Inhalation and Respiratory Drug Delivery
University of Toronto
2021-2025
Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) is a light-gated channel used for optogenetic silencing of mammalian neurons. It selects K
Structural information on channelrhodopsins' mechanism of light-gated ion conductance is scarce, limiting its engineering as optogenetic tools. Here, we use single-particle cryo-electron microscopy peptidisc-incorporated protein samples to determine the structures slow-cycling mutant C110A kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) in dark and upon laser flash excitation. Upon photoisomerization retinal chromophore, retinylidene Schiff base NH-bond reorients...
The COVID-19 pandemic represents a global challenge that has impacted and is expected to continue impact the lives health of people across world for foreseeable future. rollout vaccines provided highly anticipated relief, but effective therapeutics are required further reduce risk severity infections. Monoclonal antibodies have been shown be as SARS-CoV-2, new variants concern (VoC) emerge, their utility use waned due limited or no efficacy against these variants. Furthermore, cumbersome...