A5028636270- Diet and metabolism studies
- Eosinophilic Disorders and Syndromes
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Diabetes Treatment and Management
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Neuroblastoma Research and Treatments
- Eosinophilic Esophagitis
- Advanced Glycation End Products research
- Bat Biology and Ecology Studies
- Asthma and respiratory diseases
- Renal Diseases and Glomerulopathies
- Acute Myocardial Infarction Research
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Diet, Metabolism, and Disease
- Drug-Induced Adverse Reactions
- Healthcare Systems and Public Health
- GDF15 and Related Biomarkers
- Cardiovascular Function and Risk Factors
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- Enzyme Production and Characterization
- Liver Disease and Transplantation
Peking Union Medical College Hospital
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Qilu Hospital of Shandong University
2024
First Affiliated Hospital of Guangdong Pharmaceutical University
2019-2024
Fudan University
2024
Academy of Medical Sciences
2023
Jiangsu University
2013
Affiliated Hospital of Jiangsu University
2013
Eosinophil-induced adverse events (Eo-irAEs) have been observed in patients treated with programmed cell death 1/ligand 1 (PD-1/PD-L1) inhibitors. Surprisingly, the clinical features and outcomes of Eo-irAEs induced by PD-1/PD-L1 inhibitors not yet elucidated. This study investigated characteristics risk factors for We extracted data on related to from FDA Adverse Event Reporting System (FAERS) 2015 2023. Disproportionality Bayesian analyses were applied mining analysis. A total 430 included...
Abstract Context The hemoglobin glycation index (HGI) is correlated with metabolic diseases and inflammation. Whether the HGI associated aging process how inflammation oxidative stress affect relationship remain unclear. Objective We aimed to analyze links between biomarkers, explore a potential role of in correlations. Methods A cross-sectional study 434 subjects different glucose intolerances rural community was enrolled. calculated as difference measured predicted A1c (HbA1c). population...
Eosinophilia is a rare disease characterized by an increase in eosinophils. Suplatast tosilate selective Th2 cytokine inhibitor that can reduce There currently lack of clinical studies suplatast the treatment eosinophilia. To explore whether blood eosinophil levels eosinophilia and factors might influence improvement. A real-world retrospective study 20 patients with was conducted using electronic medical record information. The main outcome measure difference peripheral absolute count (AEC)...
To explore the relationship between hypertensive snowbirds' length of migratory stay and their blood pressure control levels.
Abstract Objective To investigate the clinical characteristics of patients with multiple endocrine neoplasia type 1 (MEN1)-related insulinoma and their relationship specific biochemical changes to summarize features treatment options for Chinese population this disease impact on long-term prognosis. Methods “MEN1” “insulinoma” were used when searching Peking Union Medical College Hospital (PUMCH) medical record retrieval system obtain information about patients. We identified diagnosed...
This study is aimed at evaluating the relationship between leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn) in a noninterventional rural community of China with different glucose tolerance statuses. In addition, we investigate whether indicators oxidative stress inflammation were involved identify mediators among them. A total 450 subjects included divided into two groups according to 75 g oral test (OGTT): abnormal metabolism (AGM, n = 257, 57.1%) group normal...
To determine the predictive value of dynamic changes neutrophil/lymphocyte ratio (NLR) combined with model end-stage liver disease (MELD) score in patients acute-on-chronic hepatitis B failure.
Objective To investigate the changes of left ventricular structure and function in stage 3-5 chronic kidney disease (CKD) patients with pulmonary hypertension (PH). Methods Clinical data 94 cases non-dialysis CKD hospitalized department nephrology our hospital from January 2016 to June 2018 were collected, including 37 PH 57 without PH. Cardiac measured echocardiography. The clinical echocardiographic parameters group non compared. Results Estimated glomerular filtration rate...
Abstract Background： China is rapidly transforming into an aging society and houses the largest elderly population in world. Diet patterns increase inflammation oxidative stress, which may provide effective intervention strategies for mitigating health burden societies. This study sought to develop a Chinese empirical dietary inflammatory index(CEDII) that assesses diet quality based on its potential examine whether index was associated with accelerated process. Methods: A cross-sectional...
Objective To investigate the relationship of serum high-sensitivity cardiac troponin I (hs-cTnI) with left ventricular structure and function in elderly hemodialysis patients. Methods 92 patients undergoing maintenance at our center were selected between January, 2015 June, 2018. Their clinical data collected. measured by echocardiography. Results The hs-cTnI increased 32 patients, was normal 60 patients. The proportions III- IV grade hypertrophy (LVH) significantly higher...
糖尿病肾病（DKD）是糖尿病最常见的微血管并发症之一，其发病机制复杂，治疗手段有限，寻找新的方法防治DKD已成为当今研究的重要方向。有研究发现，胰高血糖素样肽1受体激动剂（GLP-1RAs）具有不依赖于血糖的肾脏保护作用，可预防蛋白尿的发生，可能有助于延缓2型糖尿病患者估算肾小球滤过率（eGFR）的下降。本文就GLP-1RAs的肾脏保护机制及临床证据进行综述。
报道1例青少年异位促肾上腺皮质激素综合征（EAS）患者，其临床表现及生化改变支持促肾上腺皮质激素（ACTH）依赖性库欣综合征。大剂量地塞米松抑制试验可被抑制，鞍区磁共振成像示垂体右翼可疑微腺瘤（5 mm×7 mm）,但岩下窦静脉取血+去氨加压素（DDAVP）兴奋试验阴性。胸部CT示右肺中叶小结节（11.3 mm），氟代脱氧葡萄糖正电子发射断层成像术/计算机断层成像术（(18)FDG-PET/CT）及(68)Ga标记生长抑素受体的正电子发射断层成像术/计算机断层成像术（(68)Ga-DOTA-PET/CT）均显示该结节摄取仅轻度增加（SUVmax分别为1.1、1.6），虽SUV不高，仍考虑异位ACTH病灶不除外。胸腔镜下右肺中叶切除术后病理证实为类癌，术后ACTH、血皮质醇显著下降，患者恢复良好。EAS是儿童青少年库欣综合征的罕见病因，正确诊断和合理治疗对改善预后十分重要。诊断常需综合多种定性定位检查手段进行综合判断。当其他检查未发现明确病灶时，(68)Ga-DOTA-PET/CT和(18)FDG-PET/CT摄取仅轻度增高的病灶也需警惕类癌可能。.