A5031213111- Genetic diversity and population structure
- Advanced biosensing and bioanalysis techniques
- Genetic and Environmental Crop Studies
- Biosensors and Analytical Detection
- Tuberculosis Research and Epidemiology
- Insect Pest Control Strategies
- Immune Cell Function and Interaction
- HIV Research and Treatment
- Identification and Quantification in Food
- Advanced Biosensing Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Mycobacterium research and diagnosis
- Protein purification and stability
- Silkworms and Sericulture Research
- Diverse Scientific Research Studies
- HIV/AIDS drug development and treatment
- Plasmonic and Surface Plasmon Research
- Electrochemical sensors and biosensors
- Electrochemical Analysis and Applications
- Chromosomal and Genetic Variations
- Metal complexes synthesis and properties
- bioluminescence and chemiluminescence research
- Forecasting Techniques and Applications
- Photochemistry and Electron Transfer Studies
- Morphological variations and asymmetry
Assam Down Town University
2023-2025
Indian Institute of Technology Kanpur
2024
Central University of South Bihar
2017-2024
Mahatma Gandhi Central University
2017-2023
Oriental University
2020
Indian Institute of Science Bangalore
2012-2018
Indira Gandhi National Tribal University
2015-2017
Mahatma Gandhi University
2017
Banaras Hindu University
2007-2010
The signal peptide plays a key role in targeting and membrane insertion of secretory proteins both prokaryotes eukaryotes. In E. coli, recombinant can be targeted to the periplasmic space by fusing naturally occurring sequences their N-terminus. model protein thioredoxin was fused at its N-terminus with malE pelB sequences. While WT fusion are soluble when expressed, inclusion bodies refolded vitro yield monomeric product identical secondary structure thioredoxin. purified were studied...
ABSTRACT This study examines the socio‐environmental effects of sand‐casting and frequent floods in Subansiri River Basin order to assess climate‐induced vulnerabilities. According study, households area are moderately vulnerable, with a total livelihood vulnerability index (LVI) score 0.45. Their is increased by socioeconomic variables such as unpredictable access resources heavy reliance on agriculture, which present 61% paddy fields. Among specific vulnerabilities food insecurity, affects...
b12, one of the few broadly neutralizing antibodies against HIV-1, binds to CD4 binding site (CD4bs) on gp120 subunit HIV-1 Env. Two small fragments gp120, b121a and b122a, which display about 70% b12 epitope include solubility-enhancing mutations, were designed. Bacterially expressed b121a/b122a partially folded could bind but not CD4bs-directed non-neutralizing antibody b6. Sera from rabbits primed with or b122a protein boosted full-length showed broad activity in a TZM-bl assay 16-virus...
Summary The present study, which is one of the longest temporal (two decades) and largest spatial (different parts India covered) investigations on inversion polymorphism in natural populations D. ananassae , was undertaken to understand dynamics a broad comprehensive manner. Forty-five from different ecogeographic regions country (covering Kashmir Kanniyakumari Gujarat Nagaland) were analysed for chromosomal inversions. All show presence three cosmopolitan inversions, frequencies vary among...
Drosophila ananassae is a cosmopolitan and domestic species distributed in the tropical, subtropical mildlytemperate regions. Population structure analysis forty-five Indian natural populations of D. was performedemploying three inversions as markers. Pairwise FST genetic distance (D) values showed stronggenetic differentiation. Though, lowermost correspond to geographically closest populations, we did not find anysignificant ‘isolation by distance’ effect. Values gene flow based on...
Tuberculosis (TB) is still one of the severe progressive threats in developing countries. There are some limitations to social and economic development among nations. The present study forecasts notified prevalence TB based on seasonality trend by applying SARIMA-NNAR hybrid model. NIKSHAY database repository provides monthly informed cases (2017 2022) India. A time series model was constructed seasonal autoregressive integrated moving averages (SARIMA), neural network (NNAR), and,...
Recent advances in Recombinant antibody technology / Antibody Engineering has given impetus to the genetic manipulation of fragments that paved way for better understanding structure and functions immunoglobulins also escalated their use immunotherapy. Bacterial expression system such as Escherichia coli complemented this technique through recombinant antibodies. Present communication attempted optimize refolding protocol single chain fragment variable (ScFv) antigen binding (ScFab) using...
Forty-five natural populations of Drosophila ananassae and laboratory stocks made from these flies were analyzed for chromosome inversions. Quantitative data on the frequencies inversions utilized to test intra- interchromosomal interactions in D. ananassae. In most as well no significant deviation randomness associations (2L-3L, 2L-3R, 3L-3R) was found hence, providing evidence random associations. However, some instances, both populations, which could be due excess certain combinations,...
Protein-protein, protein-ligand and protein-lipid interactions are fundamental to most of the physiological processes.Membrane proteins particularly very important in this regard as marketed drugs those under clinical trials target these either activating or inhibiting their activity thus reflecting importance human health disease.This perceived warrants detailed analysis process understand elucidate underlying mechanisms behind process.However, there significant constraints like lack high...
Background: Globally, human tuberculosis (TB), continues to be one of the deadliest public health problem, despite some recent ground success. According Global TB Report 2014 World over, is showing a gradual declining trend, and during period 2000 2013, an estimated 37 million lives were saved largely due improvements in its diagnosis treatment. Nevertheless, because deaths are considered preventable, it only necessary that work must continue further improve on both these fronts. chronic...
Background. India is one of the countries in world most heavily impacted by tuberculosis (TB). In 2015, TB was a leading cause death, killing 1.4 million people worldwide. The aim study to assess knowledge and associated factors regarding transmission among women India. Method. We used publicly available datasets collected as part NFHS during 2015–16 Data related sociodemographic about (N = 699,686) were extracted using STATA. Multiple logistic regression analyses determine with women....