A5035672602- Neuroscience and Neuropharmacology Research
- BIM and Construction Integration
- melanin and skin pigmentation
- Skin Protection and Aging
- Cellular transport and secretion
- Ion channel regulation and function
- Microtubule and mitosis dynamics
- Receptor Mechanisms and Signaling
- Advanced Photocatalysis Techniques
- Protein Kinase Regulation and GTPase Signaling
- Neonatal Respiratory Health Research
- Neurogenesis and neuroplasticity mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Copper-based nanomaterials and applications
- Memory and Neural Mechanisms
- Ubiquitin and proteasome pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- 3D Surveying and Cultural Heritage
- Cancer-related Molecular Pathways
- Advanced Fluorescence Microscopy Techniques
- MicroRNA in disease regulation
- Gas Sensing Nanomaterials and Sensors
- Biochemical Analysis and Sensing Techniques
- Circular RNAs in diseases
- 3D Modeling in Geospatial Applications
University of California, Davis
2018-2023
RIKEN Center for Brain Science
2014-2020
Logos Biosystems (South Korea)
2019
Government of the Republic of Korea
2018
Hanyang University
2013-2018
Kwangwoon University
2013-2018
Korea University
2017-2018
Kyung Hee University
2018
Daegu Fatima Hospital
2017-2018
Seoul Institute
2018
The small GTPases Rac1 and Cdc42 are key regulators of the morphogenesis actin-rich dendritic spines in neurons. However, little is known about how activated Rac1/Cdc42 regulates spines. Insulin receptor substrate 53 (IRSp53), which highly expressed postsynaptic density (PSD), to link downstream effectors for actin regulation non-neural cells. Here, we report that IRSp53 interacts with two specific members PSD-95 family, chapsyn-110/PSD-93, brain. An mutant lacking C-terminal PSD-95-binding...
IRSp53 is an adaptor protein that acts downstream of Rac and Cdc42 small GTPases implicated in the regulation membrane deformation actin filament assembly. In neurons, abundant postsynaptic regulates actin-rich dendritic spines; however, its vivo functions have not been explored. We characterized transgenic mice deficient expression. Unexpectedly, IRSp53(-/-) neurons do show significant changes density ultrastructural morphologies spines. Instead, exhibit reduced AMPA/NMDA ratio excitatory...
Rutin, a quercetin glycoside is member of the bioflavonoid family which known to possess antioxidant properties. In present study, we aimed confirm anti‑aging effects rutin on human dermal fibroblasts (HDFs) and skin. We examined using cell viability assay, senescence-associated-β-galactosidase reverse transcription-quantitative polymerase chain reaction, by measuring reactive oxygen species (ROS) scavenging activity in vitro. To examine vivo, rutin‑containing cream was applied A...
Rho family small GTPases are important regulators of neuronal development. Defective regulation causes nervous system dysfunctions including mental retardation and Alzheimer's disease. Rac1, a member the family, regulates dendritic spines excitatory synapses, but relatively little is known about how synaptic Rac1 negatively regulated. Breakpoint cluster region (BCR) Rac GTPase-activating protein to form fusion with c-Abl tyrosine kinase in Philadelphia chromosome-positive chronic myelogenous...
Resveratrol is a plant phenolic phytoalexin that has been reported to have antitumor properties in several types of cancers. In particular, studies suggested resveratrol exerts antiproliferative effects against A549 human non-small cell lung cancer cells; however, its mechanism action remains incompletely understood. Deregulation microRNAs (miRNAs), class small, noncoding, regulatory RNA molecules involved gene expression, strongly correlated with cancer. this study, we demonstrated...
Though ursolic acid (UA) isolated from Oldenlandia diffusa was known to exhibit anti-cancer, anti-inflammatory, and anti-obesity effects, the underlying antitumor mechanism of not fully understood date. Thus, in present study, apoptotic elucidated HCT116 HT29 colorectal cancer cells association with STAT3 microRNA-4500 (miR-4500) by MTT assay, Terminal deoxynucleotidyl transferase-dT-mediated dUTP nick end labelling (TUNEL) cell cycle analysis, immunofluorescence, Western blotting. Ursolic...
Apigenin (4',5,7-trihydroxyflavone) is a flavone that has been reported to have anti-inflammatory, antioxidant and anti-carcinogenic properties. In this study, we investigated the protective effects of apigenin on skin found that, in experiments using cells, restored viability normal human dermal fibroblasts (nHDFs), which had decreased by exposure ultraviolet (UV) radiation UVA range. Using senescence-associated (SA)-β-gal assay, also demonstrate protects against UVA-induced senescence...
In the hippocampus, locations associated with salient features are represented by a disproportionately large number of neurons, but cellular and molecular mechanisms underlying this over-representation remain elusive. Using longitudinal calcium imaging in mice learning to navigate virtual reality, we find that reward landmark mediated persistent separable subsets distinct time courses emergence differing mechanisms. Strikingly, lacking Shank2, an autism spectrum disorder (ASD)-linked gene...
The cellular and molecular mechanisms underlying the development maintenance of dendritic spines are not fully understood. ADP-ribosylation factor 6 (ARF6) is a small GTPase known to regulate actin remodeling membrane traffic. Here, we report involvement ARF6 exchange for (EFA6A) in regulation spine maintenance. An active form promotes formation at expense filopodia. EFA6A an activation-dependent manner. Knockdown by interfering RNA decreases formation. Live imaging indicates that knockdown...
Long-term depression (LTD) is a long-lasting activity-dependent decrease in synaptic strength. NMDA receptor (NMDAR)–dependent LTD, an extensively studied form of involves the endocytosis AMPA receptors (AMPARs) via protein dephosphorylation, but underlying mechanism has remained unclear. We show here that regulated interaction endocytic adaptor RalBP1 with two proteins, small GTPase RalA and postsynaptic scaffolding PSD-95, controls NMDAR-dependent AMPAR during LTD. NMDAR activation...
Hypoxia is a common feature of tumors that occurs across wide variety malignancies. Multiple myeloma an incurable malignant disorder plasma cells in the bone marrow. Although marrow hypoxia crucial for normal hematopoiesis, effect on multiple poorly understood. In this study, we demonstrated cobalt chloride (CoCl2)-mediated decreased cell viability and altered gene expression U266 human cells. CoCl2 induced loss concentration-dependent manner. addition, FACS analysis revealed was related to...