A5101759878- Genomics and Phylogenetic Studies
- Molecular Biology Techniques and Applications
- Plant Molecular Biology Research
- Plant nutrient uptake and metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Business Strategy and Innovation
- Chronic Kidney Disease and Diabetes
- Birth, Development, and Health
- RNA and protein synthesis mechanisms
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- Soybean genetics and cultivation
- Evolution and Genetic Dynamics
- Plant Genetic and Mutation Studies
- Photosynthetic Processes and Mechanisms
- Chromosomal and Genetic Variations
- Immunotherapy and Immune Responses
- Genetic diversity and population structure
- Pediatric Urology and Nephrology Studies
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Bacterial Genetics and Biotechnology
Jackson Laboratory
2013-2023
University of Georgia
2008-2013
Low-cost short read sequencing technology has revolutionized genomics, though it is only just becoming practical for the high-quality de novo assembly of a novel large genome. We describe Assemblathon 1 competition, which aimed to comprehensively assess state art in methods when applied current technologies. In collaborative effort, teams were asked assemble simulated Illumina HiSeq data set an unknown, diploid A total 41 assemblies from 17 different groups received. Novel haplotype aware...
Significance Understanding dendritic cell (DC) migration during an immune response is fundamental to defining the rules that govern T cell-mediated immunity. We recently described mice deficient in pattern recognition receptor NLRP10 (NLR family, pyrin domain containing 10) with a severe DC defect. Using whole-exome sequencing, we discovered this defect was due mutation of guanine nucleotide exchange factor Dock8 (dedicator cytokinesis 8). DOCK8 regulates cytoskeleton dynamics leukocytes,...
Abstract Isogenic laboratory mouse strains enhance reproducibility because individual animals are genetically identical. For the most widely used isogenic strain, C57BL/6, there exists a wealth of genetic, phenotypic, and genomic data, including high-quality reference genome (GRCm38.p6). Now 20 years after first release genome, C57BL/6J mice at least 26 inbreeding generations removed from GRCm38 strain is now maintained with periodic reintroduction cryorecovered derived single breeder pair,...
The prevalence of chronic kidney disease (CKD) is rising worldwide and 10–15% the global population currently suffers from CKD its complications. Given increasing there an urgent need to find novel treatment options. American black bear (Ursus americanus) copes with months lowered function metabolism during hibernation without devastating effects on other consequences observed in humans. In a biomimetic approach better understand adaptations physiology hibernating bears, we established...
An effective way to understand the genomics of divergence in non-model organisms is use transcriptome identify genes associated with divergence. We examine song sparrow (Melospiza melodia) and contrast it avian models zebra finch (Taeniopygia guttata) chicken (Gallus gallus). aimed (i) obtain a functional annotation substantial portion transcriptome; (ii) compare transcript divergence; (iii) efficiently characterize single nucleotide polymorphism/indel markers possibly fixed between...
Abstract Motivation: Genomes contain biologically significant information that extends beyond encoded in genes. Some of this relates to various short dispersed repeats distributed throughout the genome. The goal work was combine tools for detection statistically DNA sequences with aid development hypotheses regarding their possible physiological functions an easy-to-use web-based environment. Results: Ab Initio Motif Identification Environment (AIMIE) designed facilitate investigations...
ABSTRACT Isogenic laboratory mouse strains are used to enhance reproducibility as individuals within a strain essentially genetically identical. For the most widely isogenic strain, C57BL/6, there is also wealth of genetic, phenotypic, and genomic data, including one highest quality reference genomes (GRCm38.p6). However, living reagents hence genetic drift occurs an unavoidable source accumulating variability that can have impact on over time. Nearly 20 years after first release genome,...
Dynamic regulation and packaging of genetic information is achieved by the organization DNA into chromatin. Nucleosomal core histones, which form basic repeating unit chromatin, are subject to various post-translational modifications such as acetylation, methylation, phosphorylation, ubiquitinylation. These have effects on chromatin structure and, along with regulate gene transcription. The goal this study was determine if patterns in were related different categories genomic features, so,...
Abstract Personalized medicine holds great promise for improving cancer outcomes, yet there is a large inequity in the demographics of patients from whom genomic data and models, including patient derived xenografts (PDX), are developed treatments optimized. In this study we develop genetic ancestry pipeline Cancer Genomics Cloud, which use to assess diversity models currently available National Institute (NCI) supported PDX Development Trial Centers Research Network (PDXNet). We show that...
Abstract The prevalence of chronic kidney disease (CKD) is rising worldwide and 10-15% the global population currently suffers from CKD its complications. Given increasing there an urgent need to find novel treatment options. American black bear ( Ursus americanus ) copes with months lowered function metabolism during hibernation without devastating effects on other consequences observed in humans. In a biomimetic approach better understand adaptations physiology hibernating bears, we...