A5084448599- Gut microbiota and health
- Metabolomics and Mass Spectrometry Studies
- Tryptophan and brain disorders
- Pancreatic function and diabetes
- Platelet Disorders and Treatments
- Blood disorders and treatments
- Pluripotent Stem Cells Research
- Bioinformatics and Genomic Networks
- Blood groups and transfusion
- CRISPR and Genetic Engineering
- Probiotics and Fermented Foods
Ludwig-Maximilians-Universität München
2021-2023
Wellcome/MRC Cambridge Stem Cell Institute
2018
Medical Research Council
2018
NHS Blood and Transplant
2017-2018
University of Cambridge
2017-2018
Abstract A key challenge in microbiome research is to predict the functionality of microbial communities based on community membership and (meta)-genomic data. As central microbiota functions are determined by bacterial networks, it important gain insight into principles that govern bacteria-bacteria interactions. Here, we focused growth metabolic interactions Oligo-Mouse-Microbiota (OMM12) synthetic community, which increasingly used as a model system gut research. Using bottom-up approach,...
A challenging task to understand health and disease-related microbiome signatures is move beyond descriptive community-level profiling towards disentangling microbial interaction networks. Using a synthetic gut bacterial community, we aimed study the role of individual members in community assembly, identify putative keystone species test their influence across different environments. Single-species dropout experiments reveal that strain relationships strongly vary not only regions murine...
Platelets are anuclear cells that essential for blood clotting. They produced by large polyploid precursor called megakaryocytes. Previous genome-wide association studies in nearly 70,000 individuals indicated single nucleotide variants (SNVs) the gene encoding actin cytoskeletal regulator tropomyosin 4 (TPM4) exert an effect on count and volume of platelets. Platelet number independent risk factors heart attack stroke. Here, we have identified 2 unrelated families BRIDGE Bleeding Disorders...
The production of blood cells and their precursors from human pluripotent stem (hPSCs) in vitro has the potential to make a significant impact upon healthcare provision. We demonstrate that forward programming hPSCs through overexpression GATA1, FLI1, TAL1 leads population progenitors can differentiate into megakaryocyte or erythroblasts. Using "rainbow" lentiviral vectors quantify individual transgene expression single cells, we cell fate decision toward an erythroblast is dictated by level...
Abstract Microbe-microbe interactions are critical for gut microbiome function. A challenging task to understand health and disease-related signatures is move beyond descriptive community-level profiling towards disentangling microbial interaction networks. Here, we aimed determine members taking on a keystone role in shaping community ecology of widely used synthetic bacterial (OMM 12 ). Using single-species dropout communities metabolomic profiling, identified Bacteroides caecimuris I48,...