A5014026475- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 and COVID-19 Research
- Blood groups and transfusion
- Bacteriophages and microbial interactions
Université de Montréal
2017-2019
Université de Yaoundé I
2013
Identifying recent HIV-1 infections is crucial for monitoring incidence and optimizing public health prevention efforts. To identify infections, we evaluated compared the performance of 4 sequence-based diversity measures including percent diversity, complexity, Shannon entropy number haplotypes targeting 13 genetic segments within env gene HIV-1. A total 597 diagnostic samples obtained in 2013 2015 from recently chronically infected individuals were selected. From selected samples, 249 (134...
Background: HIV-1 transmitted/founder viruses (TF) are selected during the acute phase of infection from a multitude virions present transmission. They possess capacity to establish and viral dissemination in new host. Deciphering discrete genetic determinant infectivity their envelope may provide clues for vaccine design. Methods: One hundred twenty-six clade B consensus sequences untreated early infected individuals were compared 105 obtained chronically using next generation sequencing...
Difficulties in systematically monitoring HIV viral load resource-limited settings prompt the search for alternate approaches. The authors aimed at assessing correlation between plasma levels of soluble forms Fas receptors (Fas) and ligands (FasL) with standard indicators disease progression children.Twenty-two HIV-1-positive children were enrolled Yaounde. CD4 counts, CD4% Fas, FasL, HIV-1 RNA assayed.The coefficients (P values) FasL each load, were, respectively, .56 (.01), -.29 (.18), .30...
Background: Despite the availability of vaccines against SARS‑CoV‑2, mortality due to COVID-19 continues increase, with nearly 7 million deaths reported globally. Continued analysis evolution and genomic diversity can provide necessary information timely inform public health responses. We report dynamics SARS‑CoV‑2 lineages in Burkina Faso between August 2021 September 2022.Methodology: A total 188 patients, whose nasopharyngeal and/or oropharyngeal swabs tested positive for SARS-CoV-2 by...
The identification of transmission clusters (TCs) HIV-1 using phylogenetic analyses can provide insights into viral network and help improve prevention strategies. We compared the use partial envelope fragment 1,070 bp with its loop 3 (108 bp) to determine utility in inferring clustering. Serum samples recently (