A5067120145- Nanoplatforms for cancer theranostics
- Luminescence and Fluorescent Materials
- Photodynamic Therapy Research Studies
- Advanced Nanomaterials in Catalysis
- Molecular Sensors and Ion Detection
- Covalent Organic Framework Applications
- Polydiacetylene-based materials and applications
- Photoreceptor and optogenetics research
- Advanced biosensing and bioanalysis techniques
- biodegradable polymer synthesis and properties
- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- Nicotinic Acetylcholine Receptors Study
- Ion channel regulation and function
- Graphene and Nanomaterials Applications
- Nanoparticle-Based Drug Delivery
- Conducting polymers and applications
- Cellular Mechanics and Interactions
- Porphyrin and Phthalocyanine Chemistry
- Electrochemical sensors and biosensors
- Hydrogels: synthesis, properties, applications
- Analytical Chemistry and Sensors
- Carbon dioxide utilization in catalysis
- Alzheimer's disease research and treatments
- Nanocluster Synthesis and Applications
Hebei University of Technology
2016-2025
Hebei University of Economics and Business
2024-2025
Institute of Biophysics
2015-2024
Institute of Molecular Biology and Biophysics
2020
Radboud University Nijmegen
2017
Chinese Academy of Sciences
2007-2012
Institute of Chemistry
2007-2012
Beijing National Laboratory for Molecular Sciences
2007-2012
Shandong Normal University
2007-2008
With the increasing antibiotic resistance of microorganisms, there is a growing interest in design and development new materials that are effective killing bacteria to replace conventional antibiotics. Herein, anionic water-soluble polythiophene (PTP) cationic porphyrin (TPPN) synthesized characterized. They can form complex through electrostatic interactions, efficient energy transfer from PTP TPPN occurs upon irradiation under white light (400−800 nm). The transfers triplet by intersystem...
We prepared a new conjugated polymer nanoparticle with the size of about 50 nm that is by electrostatic assembly cationic PFO and anionic poly(l-glutamic acid) anticancer drug doxorubicin (PFO/PG-Dox). The exhibits good fluorescence quantum yield, photostability, little cytotoxicity to meet essential requests for cell imaging. In PFO/PG-Dox nanoparticles, highly quenched Dox electron transfer mechanism, thus in "turn-off' state. After nanoparticles are exposed carboxypeptidase or taken up...
Herein, we have developed a composite antibacterial hydrogel with photodynamic therapy (PDT) and photothermal (PTT) capabilities, triggered by white light NIR irradiation. A water-insoluble conjugated polymer (PDPP) ability was prepared into nanoparticles the nanoprecipitation method, cell-penetrating peptide TAT grafted on surface of nanoparticles. Based our previous work that hybrid an enhanced PDT effect from polyisocyanide (PIC) cationic polythiophene (PMNT), PDPP (CPNs-TAT) are...
The regulation of reactive oxygen species (ROS)-sensitive calcium (Ca2+) channels is great significance in the treatment tumors. Here, a simple ROS generation system developed to activate ROS-sensitive ion for enhancing calcium-cascade-mediated tumor cell death under near-infrared (NIR) light irradiation. Upon irradiation with an 808 nm laser, low-lethality amount facilitates plasmid transient potential receptor melastatin-2 (pTRPM2) gene release via cleavage Se–Se bonds, which contributed...
Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although bidirectional mechanical exchange is crucial for many cell functions, it remains poorly understood. Key challenges are that majority of available matrices such studies, either natural or synthetic, difficult to control lack biological relevance. Here, we use a yet highly biomimetic hydrogel based on...
Abstract Multifunctional materials that simultaneously provide therapeutic action and image the results new strategies for treatment of various diseases. Here, it is shown water soluble conjugated polymers with a molecular design centered on polythiophene−porphyrin dyad are effective killing neighboring cells. Following photoexcitation, energy efficiently transferred from polythiophene backbone to porphyrin units, which readily produce singlet oxygen ( 1 O 2 ) toxic Due light‐harvesting...
A novel magnetic/fluorometric bimodal sensor was built from carbon dots (CDs) and MnO2. The resulting sensitive to glutathione (GSH), leading apparent enhancement of magnetic resonance (MR) fluorescence signals along with visual changes. detection strategy is based on the decomposition CDs–MnO2 through a redox reaction between GSH This process causes transformation non-MR-active MnO2 MR-active Mn2+, accompanied by restoration CDs. Compared range other CDs, polyethylenimine (PEI) passivated...
Abstract Hybrid biomimetic hydrogels with enhanced reactive oxygen species (ROS)‐generation efficiency under 600 nm light show high antibacterial activity. The hybrid gels are composed of helical tri(ethylene glycol)‐functionalized polyisocyanides (PICs) and a conformation‐sensitive conjugated polythiophene, poly(3‐(3′‐ N , ‐triethylammonium‐1′‐propyloxy)‐4‐methyl‐2,5‐thiophene chloride) (PMNT). PIC polymer serves as scaffold to trap align the PMNT backbone into highly ordered conformation,...
Abstract Excess accumulation of amyloid‐β (Aβ) protein in the brain is primary pathogenesis Alzheimer's disease (AD). Inhibition Aβ fibrillation and disaggregation fibrils an attractive therapeutic preventive strategy for Aβ‐induced AD. Here, near infrared (NIR) light‐responsive nanoparticles (NPs) composed amphiphilic guanidinocalix[5]arene (GC5A), 4‐(dodecyloxy)benzamido‐terminated methoxy poly(ethylene glycol), photothermal conjugated polymer PDPP are fabricated. The NIR NPs can...
The conformation of calmodulin (CaM) changes from closed configuration to open one, converting a claviform dumbbell‐shaped biomolecule upon Ca 2+ ‐binding. A hybrid probe graphene oxide (GO) cationic conjugated polymer for detection the transition CaM by using FRET technique is demonstrated. stronger hydrophobic interaction and weaker electrostatic repulsion leads more adsorption surface GO binding with than that in absence (apoCaM), resulting much farther proximity between poly[(9,9‐bis(6′‐...
The regulation of the cell membrane potential plays a crucial role in governing transmembrane transport various ions and cellular life processes. However, situ on-demand modulation for ion channel is challenging. Herein, we have constructed supramolecular assembly system based on water-soluble cationic oligo(phenylenevinylene) (OPV) cucurbit[7]uril (CB[7]). controllable disassembly OPV/4CB[7] combined with subsequent click reaction provides step-by-step adjustable surface positive potential....
The extracellular matrix (ECM) orchestrates cell behavior and tissue regeneration by modulating biochemical mechanical signals. Manipulating cell-material interactions is crucial for leveraging biomaterials to regulate functions. Yet, integrating multiple cues in a single material remains challenge. Here, near-infrared (NIR)-controlled multifunctional hydrogel platforms, named PIC/CM@NPs, are introduced dictate fibroblast during wound healing tuning the oxidative stress tensions. PIC/CM@NPs...
Abstract The increasing prevalence of antibiotic resistance, driven by the overuse and misuse conventional antibiotics, has become a critical public health concern. Photothermal antibacterial therapy (PTAT) utilizes heat generated photothermal agents under light exposure to inhibit bacterial growth without inducing attracting more attention. Quinoid conjugated polymers, especially para‐azaquinodimethane (AQM) polymer, are class organic semiconductors known for efficient π‐electron...
Diabetic wounds are highly susceptible to bacterial infection, which can lead the formation of biofilms, making diabetic wound healing a major challenge. In this study, composited microneedle that incorporated drug-loaded conjugated polymer nanoparticles and basic fibroblast growth factor was prepared eliminate biofilms promote vascular regeneration. This released minocycline under near-infrared (NIR) light, effectively penetrating biofilms. The photothermal properties polymers, combined...
Enhancing the thermal stability of proteins is an important task for protein engineering. There are several ways to increase in biology, such as greater hydrophobic interactions, increased helical content, decreased occurrence thermolabile residues, or stable hydrogen bonds. Here, we describe a well-defined polymer based on β-helical polyisocyanotripeptides (TriPIC) that uses biological approaches, including bonding and interactions its exceptional aqueous solutions. The multiple arrays...
Protein aggregation is etiologically associated with a wide range of devastating neurodegenerative diseases such as Alzheimer's and prion diseases, therefore the new strategies for detection inhibition protein are urgently desired. Herein, capability cationic water‐soluble poly(phenylene vinylene) derivative (PPV‐NMe 3 + ) to detect inhibit has been explored, using hen egg white lysozyme (HEWL) model system whose triggered by UV illumination. The PPV‐NMe binds efficiently surface HEWL...
Abstract Considering recent breakthroughs in the field of optogenetics, a powerful tool is established present study to modulate activities target neurons through application light‐based methods. Near‐infrared (NIR) light enables penetration deep‐tissue. As result, it can be used functions proteins/cells. Herein, aimed develop NIR light‐sensitive drug delivery system spatially and temporally control activation loaded at stimulation sites its release from nanoparticle sensitive NIR. Owing...
Abstract A new amphiphilic conjugated polythiophene derivative ( PT–Boc ) is synthesized via Suzuki coupling reaction. The characteristic makes it form nanoaggregates in water, which hydrophobic moieties come together to the inner core. polymer shows good photostability and no toxicity human lung epithelial (A549) cells even at a high concentration (100 μg mL −1 ). It therefore meets crucial requirement for cellular imaging other biological applications. anticancer drug cisplatin used as...
The multifunctional photothermal therapy (PTT) platform with the ability to selectively kill bacteria over mammalian cells has received widespread attention recently. Herein, we prepared graphene oxide-amino(polyethyleneglycol) (GO-PEG-NH