A5043262409- Dental Implant Techniques and Outcomes
- Cellular Mechanics and Interactions
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Bone fractures and treatments
- 3D Printing in Biomedical Research
- Bone health and osteoporosis research
- Elasticity and Material Modeling
- Blood properties and coagulation
- Angiogenesis and VEGF in Cancer
- Dental materials and restorations
- Mathematical Biology Tumor Growth
- Electrospun Nanofibers in Biomedical Applications
- Force Microscopy Techniques and Applications
- Tendon Structure and Treatment
- Periodontal Regeneration and Treatments
- Hip disorders and treatments
- Microfluidic and Bio-sensing Technologies
- Medical and Biological Sciences
- Osteoarthritis Treatment and Mechanisms
- Cell Adhesion Molecules Research
- Hip and Femur Fractures
- Hydrogels: synthesis, properties, applications
- Additive Manufacturing and 3D Printing Technologies
- Dental Radiography and Imaging
KU Leuven
2016-2025
South Westphalia University of Applied Sciences
2024
Freie Universität Berlin
2024
Promethera Biosciences (Belgium)
2014-2024
University of Potsdam
2024
Prometheus Research (United States)
2019-2022
Biomechanics Institute of Valencia
2000-2019
Maastricht University
2018
VIB-KU Leuven Center for Microbiology
2017
University of Liège
2015
Abstract: Although it is generally accepted that adverse forces can impair osseointegration, the mechanism of this complication unknown. In study, static and dynamic loads were applied on 10 mm long implants (Brånemark System ® , Nobel Biocare, Sweden) installed bicortically in rabbit tibiae to investigate bone response. Each adult New Zealand black rabbits had one statically loaded implant (with a transverse force 29.4 N distance 1.5 from top implant, resulting bending moment 4.4 Ncm),...
Finite element models were created to study the stress and strain distribution around a solitary BAnemark implant. The influence of number clinically relevant parameters was examined: bone‐implant interface (fixed bond versus frictionless free contact), bone elastic properties, unicortical bicortical implant fixation presence lamina dura. Bone loading patterns in vicinity seem be very sensitive these parameters. Hence they should integrated correctly numerical vivo behaviour oral implants....
Since loading is increasingly believed to be a determining factor in the treatment outcome with oral implants, there need expand knowledge related biomechanics of implants. The aim this study gain insight distribution and magnitude occlusal forces on implants carrying fixed prostheses. This done by vivo quantification qualification these forces, which implies that not only load but also its type (axial force or bending moment) will registered. A total 13 patients an implant supported full...
Actin protrusion dynamics plays an important role in the regulation of three-dimensional (3D) cell migration. Cells form protrusions that adhere to surrounding extracellular matrix (ECM), mechanically probe ECM and contract order displace body. This results migration can be directed by mechanical anisotropy ECM. However, subcellular processes regulate 3D are difficult investigate experimentally therefore not well understood. Here, we present a computational model through degradable...
Polyacrylamide (PAM) hydrogels are commonly used as substrates for cell mechanical and mechanobiological studies because of their tunable stiffness ease handling. The dependence bulk rheological local elastic properties (assessed by Atomic Force Microscopy) PAM on its composition polymerization temperature has been extensively studied. swell when immersed in media, but the influence swelling is poorly characterized. We report here, first time, direct measurements volumetric gels throughout...
Tissues achieve their complex spatial organization through an interplay between gene regulatory networks, cell-cell communication, and physical interactions mediated by mechanical forces. Current strategies to generate in-vitro tissues have largely failed implement such active, dynamically coordinated manipulations, relying instead on extracellular matrices which respond to, rather than impose Here, we develop devices that enable the actuation of organoids. We show active forces increase...
Cells continuously sense external forces from their microenvironment, the extracellular matrix (ECM). In turn, they generate contractile forces, which stiffen and remodel this matrix. Although bidirectional mechanical exchange is crucial for many cell functions, it remains poorly understood. Key challenges are that majority of available matrices such studies, either natural or synthetic, difficult to control lack biological relevance. Here, we use a yet highly biomimetic hydrogel based on...
Abstract Blood vessel formation relies on biochemical and mechanical signals, particularly during sprouting angiogenesis when endothelial tip cells (TCs) guide through filopodia formation. The contribution of BMP receptors in defining tip-cell characteristics is poorly understood. Our study combines genetic, biochemical, molecular methods together with 3D traction force microscopy, which reveals an essential role BMPR2 for actin-driven properties (ECs). Targeting Bmpr2 reduced zebrafish...
Osteoporosis and muscle frailty are important health problems in elderly men may be partly related to biological androgen activity. This action can mediated directly through stimulation of the receptor (AR) or indirectly estrogen receptor-alpha (ERalpha) following aromatization androgens into estrogens. To assess differential AR ERalpha pathways on bone body composition, AR-ERalpha double-knockout mice were generated characterized. disruption decreased trabecular mass, whereas had no...
The healing of a fracture depends largely on the development new blood vessel network (angiogenesis) in callus. During angiogenesis tip cells lead developing sprout response to extracellular signals, amongst which vascular endothelial growth factor (VEGF) is critical. In order ensure correct vasculature, balance between stalk and cell phenotypes must be tightly controlled, primarily achieved by Dll4-Notch1 signaling pathway. This study presents novel multiscale model osteogenesis sprouting...
Angiogenesis, the formation of new bloods vessels from existing vasculature, is a process that essential during development and regeneration tissues, plays major role in diseases like cancer. Computational models have been designed to obtain better understanding mechanisms behind angiogenesis. In this paper we review computational sprouting These can be subdivided into three categories: mainly focus on tip cell migration, make distinction between cells stalk cells, consider shape dynamics....
Direct perfusion of 3D tissue engineered constructs is known to enhance osteogenesis, which can be partly attributed enhanced nutrient and waste transport. In addition flow mediated shear stresses are upregulate osteogenic differentiation mineralization. A quantification the hydrodynamic environment therefore crucial interpret compare results in vitro bioreactor experiments. This study aims deal with pitfalls numerical model preparation highly complex bone scaffold structures provide more...
Adhesion governs to a large extent the mechanical interaction between cell and its microenvironment. As initial spreading is purely adhesion driven, understanding this phenomenon leads profound insight in both cell-substrate interaction. It has been found that across wide variety of types, behavior universally follows same power laws. The simplest type providing scaling radius area with time are modified red blood cells (RBCs), whose elastic responses well characterized. Using mechanistic...