A5066478332- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Gut microbiota and health
- Probiotics and Fermented Foods
- Advanced Chemical Sensor Technologies
- 3D Printing in Biomedical Research
- RNA regulation and disease
- Listeria monocytogenes in Food Safety
- Microfluidic and Bio-sensing Technologies
- Tissue Engineering and Regenerative Medicine
- Biosensors and Analytical Detection
- Digestive system and related health
- Neurological diseases and metabolism
- Analytical Chemistry and Chromatography
- Barrier Structure and Function Studies
- Hereditary Neurological Disorders
Cleveland Clinic Lerner College of Medicine
2023-2024
San Jose State University
2020-2022
Cleveland Clinic
2022
Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial permeability and intestinal inflammation to assess probiotic intervention as live biotherapeutics. We leveraged mechanodynamic human gut-on-a-chip (Gut Chip) recreates three-dimensional layers in controlled oxygen gradient biomechanical cues, where the addition of cocktail pro-inflammatory cytokines, TNF-α IL-1β, reproducibly induced impaired barrier followed by inflammation. This inflamed leaky epithelium...
Disease detection through gas analysis has long been the topic of many studies because its potential as a rapid diagnostic technique. In particular, pathogens that cause urinary tract infection (UTI) have shown to generate different profiles volatile organic compounds, thus enabling discrimination causative agents using an electronic nose. While past performed data collection on either agar culture or jellified urine culture, this study measures headspace volume liquid samples. Evaporation...