A5101909907- Radiation Dose and Imaging
- 3D Printing in Biomedical Research
- Medical Imaging Techniques and Applications
- Gut microbiota and health
- Advanced X-ray and CT Imaging
- Advanced Sensor and Energy Harvesting Materials
- Hydrogels: synthesis, properties, applications
- Probiotics and Fermented Foods
- Microwave Engineering and Waveguides
- Autophagy in Disease and Therapy
- Curcumin's Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Catalysis and Oxidation Reactions
- Reproductive System and Pregnancy
- Advanced Drug Delivery Systems
- Complement system in diseases
- Receptor Mechanisms and Signaling
- Barrier Structure and Function Studies
- Advanced MRI Techniques and Applications
- Acoustic Wave Resonator Technologies
- Tissue Engineering and Regenerative Medicine
- Kawasaki Disease and Coronary Complications
- Additive Manufacturing and 3D Printing Technologies
- Protease and Inhibitor Mechanisms
- Microwave and Dielectric Measurement Techniques
University of California, Berkeley
2023-2024
Chan Zuckerberg Initiative (United States)
2024
University of Auckland
2024
The University of Texas at Austin
2022
Washington University in St. Louis
2010-2014
Advanced Imaging Research (United States)
2014
St Thomas' Hospital
2008
Philips (United States)
2008
Intel (United States)
2008
Although gadolinium has been the dominant paramagnetic metal for MR contrast agents, recent association of this lanthanide with nephrogenic systemic fibrosis, an untreatable disease, spawned renewed interest in alternative metals molecular imaging. We have developed a self-assembled, manganese(III)-labeled nanobialys (1), toroidal-shaped theranostic nanoparticle. In report, Mn(III) are characterized as imaging agents targeted detection fibrin, major biochemical feature thrombus. A...
Multicolored imaging: A new class of molecular imaging agent has been developed based on low-molecular-weight organically soluble bismuth to detect and quantify intraluminal fibrin presented by ruptured plaque in the context computed tomography angiograms without calcium interference. Detailed facts importance specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted authors. Please note: The...
Here, we report a pathomimetic Leaky Gut Chip that recapitulates increased epithelial permeability and intestinal inflammation to assess probiotic intervention as live biotherapeutics. We leveraged mechanodynamic human gut-on-a-chip (Gut Chip) recreates three-dimensional layers in controlled oxygen gradient biomechanical cues, where the addition of cocktail pro-inflammatory cytokines, TNF-α IL-1β, reproducibly induced impaired barrier followed by inflammation. This inflamed leaky epithelium...
Duchenne muscular dystrophy in boys progresses rapidly to severe impairment of muscle function and death the second or third decade life. Current supportive therapy with corticosteroids results a modest increase strength as consequence general reduction inflammation, albeit potential untoward long-term side effects ultimate failure agent maintain strength. Here, we demonstrate that alternative approaches rescue defective autophagy mdx mice, model dystrophy, use rapamycin-loaded nanoparticles...
The emerging demand for programmable functionalization of existing base nanocarriers necessitates development an efficient approach cargo loading that avoids nanoparticle redesign each individual application. Herein, we demonstrate in vivo a postformulation strategy lipidic nanocarrier with the use linker peptide, which rapidly and stably integrates cargos into membranes after simple mixing through self-assembling process. We exemplified this by generating VCAM-1-targeted perfluorocarbon...
Poloxamer hydrogels are of interest as injectable depot delivery systems. However, their use for delivering hydrophobic drugs, such curcumin, is limited due to poor loading capacity. Here, we evaluated the influence incorporating medium chain triglycerides (MCT) or amphiphilic polyethylene glycol 400 (PEG400) on physicochemical properties, drug loading, and in vitro compatibility a curcumin-loaded poloxamer hydrogel. 407 188 hydrogel formulations (16:6 w/w) were prepared MCT PEG400...
Mehrfarbige Bildgebung: Eine neue Klasse von molekularen Bildgebungsmitteln basierend auf niedermolekularem, organisch löslichem Bismut wurde entwickelt. Damit gelingen mittels computertomographischer Angiogramme der Nachweis und die Quantifizierung intraluminalem Fibrin in Plaquerupturen ohne Calciuminterferenz.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEstrogen influences dolichyl phosphate distribution among glycolipid pools in mouse uteriDaniel D. Carson, Jy Ping Tang, and Grace HuCite this: Biochemistry 1987, 26, 6, 1598–1606Publication Date (Print):March 1, 1987Publication History Published online1 May 2002Published inissue 1 March 1987https://doi.org/10.1021/bi00380a017RIGHTS & PERMISSIONSArticle Views22Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum...
Three-dimensional (3D) printing can be beneficial to tissue engineers and the regenerative medicine community because of its potential rapidly build elaborate 3D structures from cellular material inks. However, predicting changes structure pattern printed tissues arising mechanical activity constituent cells is technically conceptually challenging. This perspective targeted scientists interested in bioprinting, but point view as mechanically active living materials. The dynamic forces...
Dielectric properties of substrate materials have a significant impact on electrical performance packages including signaling power loss, propagation delay and crosstalk. With the focus halogen-free (HF) package substrates, it is critical to understand this material change high-speed signal integrity. In paper, closed rectangular cavity resonator an open Fabry-Perot are proposed characterize over 2 GHz - 28 range. The paper first studies metrology repeatability sensitivity sample positioning...
The objectives of the present study were: 1) to compare noninvasive MR molecular imaging utilizing Robo4 and α ν β 3 –integrin as biosignatures angiogenesis, 2) determine relative spatial distribution within tumor neovessels, 3) assess prevalence angiogenesis in a mouse model implanted with rapidly growing, syngeneic tumor. B16‐F10 melanoma bearing mice were imaged (3.0T) 11 days post implantation after intravenous administration Robo4‐, –, irrelevant‐, or non‐targeted paramagnetic...
Introduction and purpose Molecular imaging nanomedicine approaches to the diagnosis, monitoring treatment of cardiovascular diseases, e.g. atherosclerosis, could have significant consequence on medical practice outcomes. Due exquisite sensitivity MR magnetic field disturbances iron oxides (IO), a variety IO-based agents been utilized. However, despite many elegant new techniques, highly-sensitive detection visualization IO still depends disruption local field. Contrary typical agents, we...