A5069832459- Nanoplatforms for cancer theranostics
- Protein purification and stability
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Advanced Drug Delivery Systems
- Supramolecular Self-Assembly in Materials
- Enzyme Structure and Function
- Advancements in Transdermal Drug Delivery
- Bacteriophages and microbial interactions
- Bacillus and Francisella bacterial research
- Dendrimers and Hyperbranched Polymers
- Gold and Silver Nanoparticles Synthesis and Applications
- Protein Structure and Dynamics
- Quantum Dots Synthesis And Properties
- Viral gastroenteritis research and epidemiology
- Cancer Immunotherapy and Biomarkers
- Genetics, Aging, and Longevity in Model Organisms
- Viral Infections and Outbreaks Research
- Protein Interaction Studies and Fluorescence Analysis
- Hydrogels: synthesis, properties, applications
Indian Institute of Technology Bombay
2016-2024
National Institute of Pharmaceutical Education and Research
2008-2016
University of Kansas
2013-2015
Abstract Developing a nanotheranostic agent with better image resolution and high accumulation into solid tumor microenvironment is challenging task. Herein, we established light mediated phototriggered strategy for enhanced of nanohybrids. A multifunctional liposome based nanotheranostics loaded gold nanoparticles (AuNPs) emissive graphene quantum dots (GQDs) were engineered named as NFGL. Further, doxorubicin hydrochloride was encapsulated in NFGL to exhibit chemotherapy functionalized...
The role of osmolytes, and especially trehalose, in stabilizing proteins under stress conditions is now a widely accepted fact. physical chemical properties i.e., low reactivity, nonreducing nature, high glass transition temperature, affinity for water molecules, existence number polymorphs, etc., make it uniquely suitable partially unfolded protein molecules inhibiting aggregation. This article discusses the various adverse situations that face, both within cell outside, leading to their...
Since decades, conventional diagnosis and treatment strategies for cancer have been practiced widely despite their expensive time-consuming process. These contrast therapeutic agents suffer from various side-effects such as low radiodensity image resolution, rapid clearance, non-specific biodistribution, poor tumor accumulation, high-dose multiple-dose requirements, nephrotoxicity, uncontrolled exposure of high electromagnetic radiations, whole-body scans, so on. Therefore, nanosized imaging...
So far, near-infrared (NIR) light responsive nanostructures have been well-defined in cancer nanomedicine. However, poor penetration and retention tumors are the limiting factors. Here, we report ultrahigh of carbanosilica (graphene quantum dots, GQDs embedded mesoporous silica) solid tumors. After NIR exposure, quick (0.5 h) emission from tumor area is observed that further retained up to a week (tested 10 days) with single dose administration nanohybrids. Emissive photothermally active...
Abstract Cancer has gained much attention because of slow development advanced diagnostics and therapeutic strategies. So far, conventional procedures like surgery, radiation therapy chemotherapy are only available options for cancer treatment which have various limitations. To overcome the limitations procedures, nanodiagnostics, therapeutics emerging approaches localized diagnosis nowadays. bio-mimicking stimuli active theranostic platforms been established but they limited animal studies...
Localized cancer rates are on an upsurge, severely affecting mankind across the globe. Timely diagnosis and adopting appropriate treatment strategies could improve quality of life significantly reducing mortality morbidity rates. Recently, nanotherapeutics has precipitously shown increased efficacy for controlling abnormal tissue growth in certain sites body, among which ligand functionalized nanoparticles (NP) have caught much attention improved survival statistics via active targeting. Our...
Core-shell nanostructures are promising platforms for combination drug delivery. However, their complicated synthesis process, poor stability, surface engineering, and low biocompatibility major hurdles. Herein, a carboxymethyl chitosan-coated poly(lactide-co-glycolide) (cmcPLGA) core-shell nanostructure is prepared via simple one-step nanoprecipitation self-assembly process. Engineered tested delivery of loaded docetaxel doxorubicin in cancer-mimicked environment. The drugs...
Herein, we reported self-assembled highly dispersed hollow CuS nanoparticle clusters (CuS NC) with promising photothermal efficiency of 40.5 %, uniform particle size distribution (∼150 nm), porosity and exhibiting high biocompatibility. Further, these designed hybrid structures are engineered Doxorubicin anticancer drug molecules ([email protected] for bio-responsive chemo-photo therapy breast cancer (>70 % cell death at a concentration 20 µg mL−1).
Surface-engineered gold nanoparticles have been considered as versatile systems for theranostics applications. Moreover, surface covering or stabilizing agents on especially nanobipyramids (AuNBPs) provides an extra space cargo molecules entrapment. However, it is not well studied yet and also the preparation of AuNBPs still remains dependent largely cetyltrimethylammonium bromide (CTAB), a cytotoxic surfactant. Therefore, direct use CTAB stabilized recommended cancer Herein, we address...
Dominant Negative Inhibitor (DNI) is a translocation-deficient homolog of recombinant protective antigen Bacillus anthracis that candidate for next generation anthrax vaccine. This study demonstrates the biophysical characteristics DNI protein stored in lyophilized form at 4°C 8 y were similar to Protective Antigen (rPA). To provide information on accelerated stability DNI, samples subjected thermal stress (40°C and 70°C up 4 weeks) thoroughly evaluated using various chemical...