A5054197081- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Carbon and Quantum Dots Applications
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Indian History and Philosophy
- Photodynamic Therapy Research Studies
- Glutathione Transferases and Polymorphisms
- Quantum Dots Synthesis And Properties
- DNA and Nucleic Acid Chemistry
- DNA Repair Mechanisms
- Supramolecular Self-Assembly in Materials
- Carcinogens and Genotoxicity Assessment
- RNA and protein synthesis mechanisms
- Genomics, phytochemicals, and oxidative stress
- Nanoparticles: synthesis and applications
- Luminescence and Fluorescent Materials
- Wave and Wind Energy Systems
- SARS-CoV-2 detection and testing
Indian Institute of Technology BHU
2023-2025
Banaras Hindu University
2013-2025
KIIT University
2024
University at Buffalo, State University of New York
2024
Florida Agricultural and Mechanical University
2024
University of Tennessee Health Science Center
2024
Tufts University
2022-2024
Population Council
2024
Universidade Nova de Lisboa
2022-2024
JSS Science and Technology University
2024
Abstract Developing a nanotheranostic agent with better image resolution and high accumulation into solid tumor microenvironment is challenging task. Herein, we established light mediated phototriggered strategy for enhanced of nanohybrids. A multifunctional liposome based nanotheranostics loaded gold nanoparticles (AuNPs) emissive graphene quantum dots (GQDs) were engineered named as NFGL. Further, doxorubicin hydrochloride was encapsulated in NFGL to exhibit chemotherapy functionalized...
Nanoparticle formulations blending optical imaging contrast agents and therapeutics have been a cornerstone of preclinical theranostic applications. However, nanoparticle-based theranostics clinical translation faces challenges on reproducibility, brightness, photostability, biocompatibility, selective tumor targeting penetration. In this study, we integrate multimodal within cancer cell-derived nanovesicles, leading to biomimetic bright optotheranostics for monitoring metastasis. Upon NIR...
Purified mammalian DNA polymerase beta (beta-pol) fills short gaps of up to 6 nucleotides by a processive mechanism, and this gap-filling activity requires PO4 group on the 5'-side gap (Singhal, R. K., Wilson, S. H. (1993) J. Biol. Chem. 268, 15906-15911). To assess details bimolecular binding between beta-pol 5-nucleotide (nt) gapped radiolabeled heteropolymeric substrate, beta-pol.DNA complexes were formed, photochemically cross-linked using UV light, analyzed SDS-polyacrylamide gel...
Designing bioresponsive nanocarriers for controlled and efficient intracellular drug release cancer therapy is a major thrust area in nanomedicine. With recent recognition by the US FDA as safe material human trials, mesoporous silica nanoparticles (MSNPs) are being extensively explored promising theranostic agents. Green fluorescent carbon quantum dots (CQDs), though known possible alternatives their more toxic relatively less predecessors, gate keepers control. We report first time an...
Levels of lipid peroxidation, nitric oxide and glutathione, as well superoxide dismutase activity were evaluated in non-small cell lung cancer patients before after chemotherapy. Oxidative stress was shown to influence treatment efficacy survival these patients.The aim this study assess the level oxidative chemotherapy patients, its association with response survival.Two hundred three previously untreated 150 healthy subjects selected for study. Patients received cisplatin+etoposide,...
Surface engineered nanoparticles (metallic and nonmetallic) have gained tremendous attention for precise imaging therapeutics of cell/tumors at molecular anatomic levels.These tiny agents shown their specific physicochemical properties early-stage disease diagnosis cancer theranostics applications (imaging by a single system).For example, gold nanorods (AuNRs) demonstrate better photothermal response radiodensity applications.However, upon near infrared light exposure these AuNRs lose...
Small organic dye-based fluorescent agents are highly potent in solid tumor imaging but face challenges such as poor photostability, nonspecific distribution, low circulation, and weak binding. Nanocarriers overcome these issues with better physicochemical biological performance, particularly cancer imaging. Among the various nanosized carriers, lipid formulations clinically approved yet to be designed bright nanocontrast for diagnosis without affecting surrounding tissues. Herein,...
In this work, facile synthesis and application of targeted, dual therapeutic gold nanorods-liposome (GNR-Lipos) nanohybrid for imaging guided photothermal therapy chemotherapy is investigated. The GNR-Lipos consists GNR supported, doxorubicin (DOX) loaded liposome. GNRs not only serve as a agent increase the drug release in intracellular environment cancer cells, but also provide mechanical strength to liposomes by being decorated both inside outside bilayer surfaces. designed shows...
Selective tissue visualization and localized tumor regression without affecting the surrounding healthy tissues are critical concerns in cancer nanomedicine. Importantly, complete wrapping of a flimsy matrix like liposome by multifunctional graphene oxide is an interesting engineering idea for nanomedicine design. Moreover, designing safe biodegradable nanohybrid with significant theranostic ability current need targeted combined therapies. Here, we report comprehensive result vivo diagnosis...
Since decades, conventional diagnosis and treatment strategies for cancer have been practiced widely despite their expensive time-consuming process. These contrast therapeutic agents suffer from various side-effects such as low radiodensity image resolution, rapid clearance, non-specific biodistribution, poor tumor accumulation, high-dose multiple-dose requirements, nephrotoxicity, uncontrolled exposure of high electromagnetic radiations, whole-body scans, so on. Therefore, nanosized imaging...
Chromatin in eukaryotic cells is folded into higher order structures of nucleosome filaments, and DNA damage occurs at all levels this structural hierarchy. However, little known about the impact folding on repair enzymes. We examined catalytic activities purified human base excision (BER) enzymes uracil-containing oligonucleosome arrays, which are primarily 30 nm when incubated reaction buffers. The uracil glycosylase (UDG) apyrimidinic/apurinic endonuclease (APE) digest G:U mismatches to...
A successful design of a novel red fluorescent carbon dots liposomal nanopitchers for deep tissue visualization and on demand phototriggered combined cancer therapy. The laser irradiation produces heat reactive oxygen species that cause cell death tumor growth inhibition.
So far, near-infrared (NIR) light responsive nanostructures have been well-defined in cancer nanomedicine. However, poor penetration and retention tumors are the limiting factors. Here, we report ultrahigh of carbanosilica (graphene quantum dots, GQDs embedded mesoporous silica) solid tumors. After NIR exposure, quick (0.5 h) emission from tumor area is observed that further retained up to a week (tested 10 days) with single dose administration nanohybrids. Emissive photothermally active...