A5036124962- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Gold and Silver Nanoparticles Synthesis and Applications
- RNA Interference and Gene Delivery
- Parathyroid Disorders and Treatments
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Pancreatic and Hepatic Oncology Research
- Advanced biosensing and bioanalysis techniques
- Photoacoustic and Ultrasonic Imaging
- Advanced X-ray and CT Imaging
- Supramolecular Chemistry and Complexes
- Cardiac Imaging and Diagnostics
- Polymer Surface Interaction Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- X-ray Diffraction in Crystallography
- Molecular Sensors and Ion Detection
- Virus-based gene therapy research
- Porphyrin and Phthalocyanine Chemistry
- Graphene and Nanomaterials Applications
- Extracellular vesicles in disease
- Soft tissue tumor case studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Crystallization and Solubility Studies
Georgia Institute of Technology
2024
Indian Institute of Technology Bombay
2017-2022
Homi Bhabha National Institute
2022
The success of the mRNA vaccine against COVID-19 has garnered significant interest in development therapeutics other diseases, but there remains a strong need for stable and versatile delivery platform these therapeutics. In this study, we report on family robust hybrid lipid nanocapsules (hLNCs) mRNA. hLNCs are composed kolliphore HS15, labrafac lipophile WL1349, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), conjugate oleic acid (OA) polyethylenimines varying size (PEI─0.8, 1.8, 25...
Integrating the concept of biodegradation and light-triggered localized therapy in a functional nanoformulation is current approach onco-nanomedicine. Morphology control with an enhanced photothermal response, minimal toxicity, X-ray attenuation polymer-based nanoparticles critical concern for image-guided therapy. Herein, we describe simple design cost-effective degradable polycaprolactone-based plasmonic nanoshells integrated photothermolysis as well imaging cancer cells. The...
NIR light-responsive gold coated shrinkable thermoresponsive nanoshells as preliminary step to ablate large and deep-seated tumors using combined chemo-photothermal therapy.
Photothermal therapy (PTT), a simple and minimally invasive procedure, is an attractive option for cancer therapy. To date, inorganic agents have been widely employed as photothermal agents; however, organic molecules may provide solution to rapid metabolic/in vivo clearance. Herein, we prepared lipid (S 75)-stabilized meso-tritolyl-BF2-oxasmaragdyrin nanoparticles (TBSNPs) using thin-film hydration homogenization. Assessment of the physicochemical properties TBSNPs reveals formation...
Abstract Two structurally unique aggregation induced emission (AIE)‐active luminogens have been designed and synthesized based on the furocarbazole skeleton. Such small molecule AIEgens were forbidden planarity engineering a twist into scaffold to realize induction of in aggregated states. The structures fully characterized their thermal stabilities, electronic properties, photophysical electrochemical properties systematically investigated. molecules as evident from X‐ray crystal structure...
Cell-penetrating peptides (CPPs) are excellent cell internalizing agents for hydrophobic drug/dye moieties. We exploited this property of CPPs the internalization BF2 -oxasmaragdyrin by constructing covalent conjugates with (CRGDK and polyarginine (R9 )) using a solid-phase peptide synthesis (SPPS) methodology. The CPP-conjugated -oxasmaragdyrins were purified reversed-phase HPLC characterized mass spectrometry. found to be photostable, absorb in visible-NIR region (400-700 nm), emit NIR-I...
Abstract Photothermal therapy (PTT) has attracted great interest in cancer treatment, and the quest for potential organic photothermal agents is underway owing to nonbiodegradable nature chronic toxicity of existing inorganic nanomaterials. Organic material-based nanoformulations with good fluorescence properties near-infrared (NIR-I) window are scarce. However, porphyrins one category biocompatible systems that advantageous but currently based visible region, causing limited depth tissue...
<p class="abstract">The incidence of primary hyperparathyroidism in India is 2.5/1000 individuals. Primary can be caused by a non-cancerous parathyroid adenoma, hyperplasia or rarely carcinoma. Most these patients have few no symptoms. Correct diagnosis reached clinical settings, biochemical and radiological tests final confirmation histopathology the specimen.</p>
Abstract A value addition to the existing NIR fluorescence imaging agents has been synthesized in form of glucosamine conjugated BF 2 ‐oxasmaragdyrin by treating meso ‐ p ‐carboxyphenyl with 6‐amine‐6‐deoxy‐1‐ O ‐Boc‐2‐ N ‐Boc‐ β ‐D‐glucosamine presence HBTU. The was thoroughly characterized HRMS, 1D, and 2D NMR spectroscopy. photophysical studies revealed that conjugates are highly stable, absorb visible‐ far‐red region (400‐700 nm) emits (715 moderate quantum yields. electrochemical showed...
Background: The aim was to evaluate the incidental findings of vascular calcifications in mammogram and correlate them with coronary artery diseases clinically radiologically retrospective manner from multiple institutes.Methods: It a analysis all mammograms done past one year for routine screening three institutes during 2020-2021. Those positive were interviewed willing population we evaluated disease status radiologically.Results: There 335 subjects whose complete case records available....
Background: Photothermal therapy (PTT) is a promising cancer treatment modality which employs near-infrared laser on gold-nanomaterials for localized heat-mediated tumor ablation. We estimate PTT effect of novel CSC-targeted photothermal agent, that is, hyaluronic acid (HA)-tagged gold-solid-lipid nanoparticle (Au-SLN) breast (BC) cells and xenograft tumors.