A5040441286- Heme Oxygenase-1 and Carbon Monoxide
- Toxoplasma gondii Research Studies
- Legionella and Acanthamoeba research
- Cytomegalovirus and herpesvirus research
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Porphyrin Metabolism and Disorders
- Mosquito-borne diseases and control
- Biochemical and Molecular Research
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- S100 Proteins and Annexins
Clemson University
2019-2024
Innovation Team (China)
2024
Heme, an iron-containing organic ring, is essential for virtually all living organisms by serving as a prosthetic group in proteins that function diverse cellular activities ranging from diatomic gas transport and sensing, to mitochondrial respiration, detoxification. Cellular heme levels microbial pathogens can be composite of endogenous de novo synthesis or exogenous uptake intermediates. Intracellular pathogenic microbes switch routes supply when availability fluctuates their replicative...
Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and mortality rate remains >95% in US. Glycolysis is very important infectious trophozoite lifecycle stage inhibitors of glucose metabolism have been found be toxic pathogen. Recently, human enolase 2 (ENO2) phosphonate developed as agents treat glioblastoma...
ABSTRACT Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and mortality rate remains >95% in US. Glycolysis is very important infectious trophozoite lifecycle stage inhibitors of glucose metabolism have been found be toxic pathogen. Recently, human enolase 2 (ENO2) phosphonate developed as agents treat...
Infections of
Glucose metabolism is critical for the African trypanosome, Trypanosoma brucei, serving as lone source of ATP production bloodstream form (BSF) parasite in glucose-rich environment host blood. Recently, phosphonate inhibitors human enolase (ENO), enzyme responsible interconversion 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP) glycolysis or PEP 2-PG gluconeogenesis, have been developed treatment glioblastoma multiforme (GBM). Here, we tested these agents against T. brucei ENO (TbENO)...
Heme, an iron-enclosed organic ring, is essential for virtually all living organisms by serving as a prosthetic group in proteins that function diverse cellular activities ranging from diatomic gas transport and detection to mitochondrial respiration detoxification. Cellular heme levels microbial pathogens can be composite of endogenous de novo synthesis or exogenous uptake intermediates 1,2 . Intracellular pathogenic microbes switch routes supply when availability their replicative...