A5068964774- Nasal Surgery and Airway Studies
- Inhalation and Respiratory Drug Delivery
- Sinusitis and nasal conditions
- Obstructive Sleep Apnea Research
- Advanced Chemical Sensor Technologies
- Olfactory and Sensory Function Studies
- Allergic Rhinitis and Sensitization
- Tracheal and airway disorders
- Odor and Emission Control Technologies
- Airway Management and Intubation Techniques
- Indoor Air Quality and Microbial Exposure
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Voice and Speech Disorders
- Insect Pheromone Research and Control
- Photoacoustic and Ultrasonic Imaging
- Head and Neck Surgical Oncology
- Cleft Lip and Palate Research
- Optical Coherence Tomography Applications
- Air Quality Monitoring and Forecasting
- Cystic Fibrosis Research Advances
- Congenital Ear and Nasal Anomalies
- Food Supply Chain Traceability
- Particle Dynamics in Fluid Flows
- Chemical Safety and Risk Management
University of North Carolina at Chapel Hill
2014-2025
University of New Orleans
2022-2023
Triological Society
2020
University of North Carolina at Asheville
2018
Indiana University School of Medicine
2013-2015
University of North Carolina Health Care
2013
Medical College of Wisconsin
2011-2012
The Hamner Institutes for Health Sciences
2007-2010
Research Triangle Park Foundation
1997-2009
Massachusetts Academy of Math and Science
2005
Information on the deposition efficiency of aerosol particles in nasal airways is used for optimizing delivery therapeutic aerosols into nose and risk assessment toxic airborne pollutants inhaled through respiratory system. Nasal particle often studied using plastic replicas airways. Deposition a replica manufactured by stereolithography has not been reported to date. We determined inertial two same different machines compared results with efficiencies models other techniques from magnetic...
Extrapolation of the regional dose an inhaled xenobiotic from laboratory animals to humans for purposes assessing human health risk is problematic because large interspecies differences in nasal respiratory physiology and airway anatomy. There a need dosimetry models that can adjust these upper tract. The present work extends previous efforts this elsewhere simulate airflow profiles numerically humans. A three-dimensional, anatomically accurate representation adult cavity nasopharynx was...
Atrophic rhinitis is a chronic disease of the nasal mucosa. The characterized by abnormally wide cavities, and its main symptoms are dryness, crusting, atrophy, fetor, paradoxical sensation congestion. etiology remains unknown. Here, we propose that excessive evaporation mucous layer basis for relentless nature this disease. Airflow water heat transport were simulated using computational fluid dynamics (CFD) techniques. geometry an atrophic patient was acquired from computed tomography scans...
Many studies suggest limited effectiveness of spray devices for nasal drug delivery due primarily to high deposition and clearance at the front nose. Here, behavior was studied using experimental measurements a computational fluid dynamics model human passages constructed from magnetic resonance imaging scans healthy adult male. Eighteen commercially available sprays were analyzed characteristics laser diffraction, high-speed video, spark photography. Steadystate, inspiratory airflow (15...
Context: Inhaled nanoparticles can migrate to the brain via olfactory bulb, as demonstrated in experiments several animal species. This route of exposure may be mechanism behind correlation between air pollution and human neurodegenerative diseases, including Alzheimer's disease Parkinson's disease.Objectives: article aims (i) estimate dose inhaled that deposit epithelium during nasal breathing at rest (ii) compare humans with our earlier estimates for rats.Materials methods: An...
Hypothesis: A simulated, multicolor, multi-material temporal bone model can be created using 3-dimensional (3D) printing that will prove both safe and beneficial in training for actual surgical cases. Background: As the process of additive manufacturing, or 3D printing, has become more practical affordable, a number applications technology field Otolaryngology–Head Neck Surgery have been considered. One area promise is simulation. Methods: Three-dimensional representations human bones were...
Septal deviation is an extremely common anatomic variation in healthy adults. However, there are no standard criteria to determine when a deviated septum clinically relevant. Presently, selection of patients for septoplasty based on mostly clinical examination, which prone observer bias and may lead unsuccessful treatment. The objective this article twofold. First, we investigate whether the location septal within nasal passages affects resistance. Second, test computer simulations...
Objectives To (1) quantify mucosal cooling (ie, heat loss) spatially in the nasal passages of airway obstruction (NAO) patients before and after surgery using computational fluid dynamics (CFD) (2) correlate with patient‐reported symptoms, as measured by Nasal Obstruction Symptom Evaluation (NOSE) a visual analog scale (VAS) for sensation airflow. Study Design Prospective. Setting Academic tertiary medical center. Subjects Methods Computed tomography (CT) scans NOSE VAS surveys were obtained...
Abstract Topical intra-nasal sprays are amongst the most commonly prescribed therapeutic options for sinonasal diseases in humans. However, inconsistency and ambiguity instructions show a lack of definitive knowledge on best spray use techniques. In this study, we have identified new usage strategy nasal available over-the-counter, that registers an average 8-fold improvement topical delivery drugs at diseased sites, when compared to prevalent The protocol involves re-orienting axis harness...
The human nasal passages effectively filter particles from inhaled air. This prevents harmful pollutants reaching susceptible pulmonary airways, but may leave the mucosa vulnerable to potentially injurious effects toxicants. filtering property also be strategically used for aerosolized drug delivery. route has recently been considered as a means of delivering systemically acting drugs due large absorptive surface area available in close proximity nostrils. In this study, computational fluid...
Background: Interindividual variability in nasal filtration is significant due to interindividual differences anatomy and breathing rate. Two important consequences arise from this variation among humans. First, devices for drug delivery may furnish quite different doses the passages of individuals, leading responses therapeutic treatment. Second, people with poor be more susceptible adverse health effects when exposed airborne particulate matter (PM) greater lung deposition. Although has...
Certain inhaled chemicals, such as reactive, water-soluble gases, are readily absorbed by the nasal mucosa upon inhalation and may cause damage to epithelium. Comparisons of spatial distribution lesions in laboratory animals exposed formaldehyde with gas uptake rates predicted computational models reveal that usually occur regions susceptible epithelium where absorption is highest. Since patterns influenced air currents nose, interindividual variability anatomy ventilation due age, body...
Background: There are methodological ambiguities in the literature on mesh refinement analysis for computational fluid dynamics (CFD) modeling of physiologically realistic airflow and particle transport human sinonasal cavity. To investigate grid independence discretization (sino)nasal geometry, researchers have considered CFD variables such as pressure drop, velocity profile, wall shear, airflow, deposition fractions. Standardization nasal geometry is also lacking: unilateral or bilateral...
Knowledge of the regional deposition inhaled particles in nose is important for drug delivery and assessment toxicity materials. In this study, computational fluid dynamics (CFD) predictions experimental measurements a nasal replica cast were used to study microparticles.The was sectioned into six regions interest based on anatomy: vestibule, valve, anterior turbinates, olfactory region, nasopharynx. Monodisperse fluorescein with aerodynamic diameters 2.6-14.3 μm passed through assembled...
Formaldehyde-induced nasal squamous cell carcinomas in rats and metaplasia rhesus monkeys occur specific regions of the nose with species-specific distribution patterns. Experimental approaches addressing local differences formaldehyde uptake patterns dose are limited by resolution dissection techniques used to obtain tissue samples rapid metabolism absorbed mucosa. Anatomically accurate, 3-dimensional computational fluid dynamics models F344 rat, monkey, human passages were estimate compare...
Abstract Information on the deposition of ultrafine particles in nasal airways is important for assessing risks exposure to airborne particulate matter and understanding drug delivery implications this diameter. Nasal particle often studied using plastic replicas airways. Ultrafine has been measured previously upper that were manufactured from magnetic resonance images or cadaver specimens. Here we determined efficiency two same by different stereolithography processes investigated...